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Database: UniProt
Entry: A0A151ML42_ALLMI
LinkDB: A0A151ML42_ALLMI
Original site: A0A151ML42_ALLMI 
ID   A0A151ML42_ALLMI        Unreviewed;      2199 AA.
AC   A0A151ML42;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   25-OCT-2017, entry version 11.
DE   RecName: Full=Voltage-dependent P/Q-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   ORFNames=Y1Q_0009019 {ECO:0000313|EMBL:KYO25237.1};
OS   Alligator mississippiensis (American alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO25237.1};
RN   [1] {ECO:0000313|EMBL:KYO25237.1, ECO:0000313|Proteomes:UP000050525}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO25237.1};
RX   PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA   St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y.,
RA   Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A.,
RA   Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D.,
RA   Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J.,
RA   Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y.,
RA   Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E.,
RA   Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J.,
RA   Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W.,
RA   Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D.,
RA   Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.;
RT   "Sequencing three crocodilian genomes to illuminate the evolution of
RT   archosaurs and amniotes.";
RL   Genome Biol. 13:415-415(2012).
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1A
CC       gives rise to P and/or Q-type calcium currents. P/Q-type calcium
CC       channels belong to the 'high-voltage activated' (HVA) group and
CC       are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-
CC       IVA (omega-Aga-IVA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KYO25237.1}.
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DR   EMBL; AKHW03005909; KYO25237.1; -; Genomic_DNA.
DR   Proteomes; UP000050525; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR005448; CACNA1A.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01632; PQVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000050525};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     56     73       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     93    113       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    176    199       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    289    311       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    438    457       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    469    489       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    501    521       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    564    586       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    640    664       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1172   1190       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1252   1270       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1316   1338       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1428   1453       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1509   1527       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1539   1562       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1568   1586       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1631   1653       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1721   1745       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1882   1916       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      660    687       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2199 AA;  251549 MW;  85191E5433B5EBF3 CRC64;
     MYKQSMAQRA RTMALYNPIP VRQNCLTVNR SLFLFSEDNV VRKYAKKITE WPPFEYMILA
     TIIANCIVLA LEQHLPDEDK TPMSERLDDT EPYFIGIFCF EAGIKIIALG FAFHKGSYLR
     NGWNVMDFVV VLTGILAKVG SEFDLRTLRA VRVLRPLKLV SGIPSLQVVL KSIMKAMIPL
     LQIGLLLFFA ILIFAIIGLE FYMGKFHTTC FDSVTGEIKD RVPCGMDEPA RTCPNGTRCS
     KYWEGPNYGI TQFDNILFAV LTVFQCITME GWTDLLYNSN DASGNTWNWL YFIPLIIIGS
     FFMLNLVLGV LSGEFAKERE RVENRRAFLK LRRQQQIERE LNGYMEWISK AEVILAEDET
     EGEQRHPFDA LQRAAIKKSK TDLLNPEEAD DQLADIASVG SPFARASIKS AKLENSTFFH
     KRERRMRFYI RRMVKTQAFY WTVLSLVALN TLCVAVVHYS QPDWLSDFLY YAEFIFLGLF
     MSEMFIKMYG LGTRPYFHSS FNCFDCAVII GSIFEVVWAV MKPGTSFGIS VLRALRLLRI
     FKVTKYWASL RNLVVSLLNS MKSIISLLFL LFLFIVVFAL LGMQLFGGQF NFDTGTPATN
     FDTFPAAIMT VFQILTGEDW NMVMYDGIKS QGGVKRGMVF SVYFIVLTLF GNYTLLNVFL
     AIAVDNLANA QELTKDEQEE EEAATQKLAL QKAKEVAEVS PLSAASMSIA VKEQQKNQKS
     SKSVWEQRTS EMRKHNLLAS REALYNELDP EERWKVSYAR PSRPDIKTHL DRPLVVDPQE
     NRNNNTNKTR PSDPPLEPRF GPPQAEDFLR KPPRYHDRPR DPGSGRTYPP PESGVPELRR
     PHSGSREMEP PVEERSYHEA DPERLKAAEP PRRHPHHQAG GKESRGGSPR DGDREHRRHR
     GHRRAGEDGG GTDEGPKSER RPRHRPGEGE MPDGERRRRH RHAAQSTYDG DGKREDKERR
     HRRRKENQGP VPVHGPHLST TRPIQQDMGR PEPPVAEDID NMKNNKLATT ETSNPHPQSP
     TKLGNHANCT PSRAPDALGQ LPPNSQNVAN RWAPDNPSQP SNPRPPKTPE NSLIVTNPGP
     QNNPTKTAKK PEYTAVEIPT TFPPPIHNTV VQVNKNANPE PLPKKDEEKK EEEADDQEEN
     RPKPMVPYSS MFILSTTNPF RRLCHYIVNL RYFEMCILMV IAMSSIALAA EDPVQPNAPR
     NNSEQSVRCR GSAGLHATPX XXXFTGVFTF EMVIKMVDLG LVLHQGAYFR DLWNILDFIV
     VSGALVAFAF TGSKGKDINT IKSLRVLRVL RPLKTIKRLP KLKAVFDCVV NSLKNVLNIL
     IVYMLFMFIF AVVAVQLFKG KFFYCTDESK EFENDCRGEY LVYEKDEVKA EKREWKKYEF
     HYDNVLWALL TLFTVSTGEG WPQVLKHSVD ATYENQGPSP GYRMEMSIFY VVYFVVFPFF
     FVNIFVALII ITFQEQGDKM MEEYSLEKNE RACIDFAISA KPLTRHMPQN KQSFQYRMWQ
     FVVSPPFEYT IMAMIALNTV VLMMKFYGAS DAYENVLKMF NNVFTSLFSL ECLLKIMAFG
     VLNYFRDAWN IFDFVTVLGS ITDILVTEFG NNFINLSFLR LFRAARLIKL LRQGYTIRIL
     LWTFVQSFKA LPYVCLLIAM LFFIYAIIGM QVFGNIGIDD KDDESAITEH NNFRTFFQAL
     MLLFRSATGE GWQEIMLSCL SGKPCDENSG IMEHECGNEF AYFYFVSFIF LCSFLMLNLF
     VAVIMDNFEY LTRDSSILGP HHLDEYVRVW AEYDPAAWGR LTFTDMYEML RHMSPPLGLG
     KKCPPRVAYK RLLRMDLPVA DDNTVHFNST LMALIRTALD IKIAKGGADK QQMDAELRKE
     MMAIWPNLSQ KTLDLLVTPH KSTDLTVGKI YAAMMIMEYY RQSKAKKLQA MREEQNRTPL
     MFQRMEPPSP GQEGGPGQDA LPPPPLDQGG GLGHEGGMKE SQSWVTQRAQ EMFQKTGTWS
     PERARPDDLP NSRPSSQSVE MREIGKDGYS DSDHYPPMQG HGRAASMPRL PAENQRRKVR
     PRGNNLSTIP DVSPMKRSAS VLGHPRARGI RLDDYSLERV PPDDAQRHHL RRRDRDRDRA
     HRASDRSLGR YADADAGLGT DLSMTPPSGE LPLKERDGER GRPKDRRHHH HHHHHHHRHE
     DGRPRDRDRD RRWSRSPSEA RDHPPPRQVG APYPTPLIL
//
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