ID A0A151MNG3_ALLMI Unreviewed; 105 AA.
AC A0A151MNG3;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=cAMP-dependent protein kinase inhibitor alpha {ECO:0000256|ARBA:ARBA00040416};
GN Name=PKIA-1 {ECO:0000313|EMBL:KYO25940.1};
GN ORFNames=Y1Q_0003725 {ECO:0000313|EMBL:KYO25940.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO25940.1};
RN [1] {ECO:0000313|EMBL:KYO25940.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO25940.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- FUNCTION: Extremely potent competitive inhibitor of cAMP-dependent
CC protein kinase activity, this protein interacts with the catalytic
CC subunit of the enzyme after the cAMP-induced dissociation of its
CC regulatory chains. {ECO:0000256|ARBA:ARBA00002844}.
CC -!- SIMILARITY: Belongs to the PKI family. {ECO:0000256|ARBA:ARBA00006393}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO25940.1}.
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DR EMBL; AKHW03005657; KYO25940.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151MNG3; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0004862; F:cAMP-dependent protein kinase inhibitor activity; IEA:InterPro.
DR InterPro; IPR004171; cAMP_dep_PKI.
DR PANTHER; PTHR15416:SF2; CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA; 1.
DR PANTHER; PTHR15416; CAMP-DEPENDENT PROTEIN KINASE INHIBITOR/PKI; 1.
DR Pfam; PF02827; PKI; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..38
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 39..105
FT /note="cAMP-dependent protein kinase inhibitor alpha"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007585338"
FT REGION 78..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 105 AA; 11056 MW; FECBB92B11CC3D66 CRC64;
MRAGDSARGR GRCAELVAAK VLLCGYLLAM TDVESTYADF IASGRTGRRN ALHDILVSST
GGNSSELALK LAELDINKTE GEGDAQRNPN EQTGEAQGEA AKQES
//
