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Database: UniProt
Entry: A0A151MRP4_ALLMI
LinkDB: A0A151MRP4_ALLMI
Original site: A0A151MRP4_ALLMI 
ID   A0A151MRP4_ALLMI        Unreviewed;      1978 AA.
AC   A0A151MRP4;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   07-JUN-2017, entry version 10.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN8A {ECO:0000313|EMBL:KYO27204.1};
GN   ORFNames=Y1Q_0011161 {ECO:0000313|EMBL:KYO27204.1};
OS   Alligator mississippiensis (American alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO27204.1};
RN   [1] {ECO:0000313|EMBL:KYO27204.1, ECO:0000313|Proteomes:UP000050525}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO27204.1};
RX   PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA   St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y.,
RA   Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A.,
RA   Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D.,
RA   Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J.,
RA   Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y.,
RA   Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E.,
RA   Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J.,
RA   Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W.,
RA   Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D.,
RA   Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.;
RT   "Sequencing three crocodilian genomes to illuminate the evolution of
RT   archosaurs and amniotes.";
RL   Genome Biol. 13:415-415(2012).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KYO27204.1}.
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DR   EMBL; AKHW03005250; KYO27204.1; -; Genomic_DNA.
DR   RefSeq; XP_006264679.2; XM_006264617.3.
DR   GeneID; 102575158; -.
DR   KEGG; amj:102575158; -.
DR   CTD; 6334; -.
DR   KO; K04840; -.
DR   Proteomes; UP000050525; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR008054; Na_channel_a8su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01667; NACHANNEL8.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000050525};
KW   Ion channel {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000313|EMBL:KYO27204.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    128    151       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    199    219       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    231    248       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    254    274       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    387    414       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    746    770       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    782    803       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    865    890       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    949    975       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1197   1215       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1236   1255       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1267   1290       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1311   1339       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1436   1462       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1521   1539       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1551   1569       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1581   1601       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1638   1666       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1741   1764       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      131    421       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      498    699       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      752    979       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      989   1190       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1195   1470       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1520   1774       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      411    449       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1978 AA;  225205 MW;  8F9A4B32CF65F40B CRC64;
     MAARLIAPPG PDSFKCFTPE SLANIEKRIA EEKKRKRPKQ DSSHRDDDED SKPKPNSDLE
     AGKSLPFIYG DIPKGLVAVP LEDFDPYYMT QKTFVVLNRG KTLFRFSATP ALYILSPFNL
     LRRIAIKILI HSVFSMIIMC TILTNCVFMT FSNPPEWSKN VEYTFTGIYT FESLVKIIAR
     GFCIDGFTFL RDPWNWLDFS VIMMAYVTEF VDLGNVSALR TFRVLRALKT ISVIPGLKTI
     VGALIQSVKK LSDVMILTVF CLSVFALIGL QLFMGNLRNK CVIWPINLNE TVLENGSRGF
     DWEEYTNNKS NFYTIPGALD PLLCGNSSDA GQCPEGYTCM KAGRNPNYGY TSFDTFSWAF
     LALFRLMTQD FWENLYQLTL RAAGKTYMIF FVLVIFVGSF YLVNLILAVV AMAYEEQNQA
     TLEEAEQKEA EFKAMLEQLK KQQEEAQAAA MVTSAGTVSE DAVEDDGGGR VSRSSSEISK
     LSSKSAKERR NRRKKRKDKE LSEGDEKCDN EKVFKSESED GMRRKAFRLP DNRLGRKFSI
     MNQSLLSIPG SPFLSRHNSK SSIFSYKGRF RDPGSENEFA DDEHSTVEES EGRRDSLFIP
     IRGRDRRSSY SGYSGYSQGS RSSRIFPNLR RNVKRNSTVD CNGVVSLIGG PTSNVPGGRL
     LPEGTTEVAI KKKPTGSLLV SMDQLNASFG RKDRTNSIMT VVTNTLVEEL EESQRKCPPC
     WYKFANTFLI WECHPHWIKL KEIVNLIVMD PFVDLAITIC IVLNTLFMAM EHHPMTPQFE
     HVLSVGNLVF TGIFTAEMFL KLIAMDPYYY FQEGWNIFDG FIVSLSLMEL GLQDVEGLSV
     LRSFRLLRVF KLAKSWPTLN MLIKIIGNSV GALGNLTLVL AIIVFIFAVV GMQLFGKSYK
     ECVCKIHPDC VLPRWHMHDF FHSFLIVFRV LCGEWIETMW DCMEVAGQAM CLIVFMMVMV
     IGNLVVLNLF LALLLSSFSA DNLAATDDDG EMNNLQISVI RIKKGIAWTK IKVHEFMQAH
     FKQREADEVK PLDELYDKKV NCIANHMGAD INRDIDYQKN GNGTTSGIGS SVEKYIIDED
     HMSFINNPNL TVRVPIAVGE SDFENLNTED FSSDTDPDGS KEKLDDTSSS EGSTIDIKPE
     VEEVPVEVPE EYLDPDPCFT EGCFKRFTCC QVNIEEGLGK SWWTLRKTCF LIVEHNWFET
     FIIFMILLSS GALAFEDIYI EQRKTIRTIL EYADKVFTYI FILEMLLKWC AYGFVKFFTN
     AWCWLDFLIV AVSLVSLIAN ALGYSELGAI KSLRTLRALR PLRALSRFEG MRVVVNALVG
     AIPSIMNVLL VCLIFWLIFS IMGVNLFAGK YHYCFNESSE ERFDIEVVNN KTDCEALMPP
     NSTEIRWKNV KINFDNVGAG YLALLQVATF KGWMDIMYAA VDSRKPEEQP KYEDNIYMYI
     YFVIFIIFGS FFTLNLFIGV IIDNFNQQKK KFGGQDIFMT EEQKKYYNAM KKLGSKKPQK
     PIPRPLNRVQ GAVFDFVTQQ AFDIVIMILI CLNMVTMMVE TDTQSKQMED ILSWINLVFV
     IFFTCECVLK MFALRHYYFT VGWNIFDFVV VILSIVGMFL AEIIEKYFVS PTLFRVIRLA
     RIGRILRLIK GAKGIRTLLF ALMMSLPALF NIGLLLFLVM FIFSIFGMSN FAYVKHEAGI
     DDMFNFETFG NSMICLFQIT TSAGWDGLLL PILNRPPDCD LYKEHPGSGF KGDCGNPSVG
     IFFFVSYIII SFLIVVNMYI AIILENFSVA TEESADPLSE DDFETFYEIW EKFDPDATQF
     IEYCKLADFA DALEHPLRVP KPNTIELIAM DLPMVSGDRI HCLDILFAFT KRVLGDSGEL
     DILRQQMEER FVASNPSKVS YEPITTTLRR KQEDVSAVVI QRAYRVRLAR RGFISRKPAS
     TKLENGGANR EKKEGTPSTA SLPSYDSVTK PEKEKQQRAE EGRRERAKRQ RDVRESKC
//
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