ID A0A151MS42_ALLMI Unreviewed; 1086 AA.
AC A0A151MS42;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Phosphorylase b kinase regulatory subunit {ECO:0000256|RuleBase:RU364123};
GN Name=PHKB {ECO:0000313|EMBL:KYO27270.1};
GN ORFNames=Y1Q_0021208 {ECO:0000313|EMBL:KYO27270.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO27270.1};
RN [1] {ECO:0000313|EMBL:KYO27270.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO27270.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- FUNCTION: Phosphorylase b kinase catalyzes the phosphorylation of
CC serine in certain substrates, including troponin I.
CC {ECO:0000256|RuleBase:RU364123}.
CC -!- PATHWAY: Glycan biosynthesis; glycogen metabolism.
CC {ECO:0000256|ARBA:ARBA00005131, ECO:0000256|RuleBase:RU364123}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004342,
CC ECO:0000256|RuleBase:RU364123}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004342, ECO:0000256|RuleBase:RU364123};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004342,
CC ECO:0000256|RuleBase:RU364123}. Membrane
CC {ECO:0000256|ARBA:ARBA00004423}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004423}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004423}.
CC -!- SIMILARITY: Belongs to the phosphorylase b kinase regulatory chain
CC family. {ECO:0000256|ARBA:ARBA00007128, ECO:0000256|RuleBase:RU364123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO27270.1}.
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DR EMBL; AKHW03005226; KYO27270.1; -; Genomic_DNA.
DR RefSeq; XP_006271264.1; XM_006271202.3.
DR AlphaFoldDB; A0A151MS42; -.
DR STRING; 8496.A0A151MS42; -.
DR GeneID; 102565146; -.
DR KEGG; amj:102565146; -.
DR CTD; 5257; -.
DR eggNOG; KOG3635; Eukaryota.
DR OrthoDB; 3640971at2759; -.
DR UniPathway; UPA00163; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0005977; P:glycogen metabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR011613; GH15-like.
DR InterPro; IPR045583; KPBA/B_C.
DR InterPro; IPR008734; PHK_A/B_su.
DR PANTHER; PTHR10749; PHOSPHORYLASE B KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10749:SF8; PHOSPHORYLASE B KINASE REGULATORY SUBUNIT BETA; 1.
DR Pfam; PF00723; Glyco_hydro_15; 1.
DR Pfam; PF19292; KPBB_C; 1.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE 3: Inferred from homology;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860,
KW ECO:0000256|RuleBase:RU364123};
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277,
KW ECO:0000256|RuleBase:RU364123};
KW Cell membrane {ECO:0000256|RuleBase:RU364123};
KW Glycogen metabolism {ECO:0000256|ARBA:ARBA00022600,
KW ECO:0000256|RuleBase:RU364123}; Kinase {ECO:0000313|EMBL:KYO27270.1};
KW Lipoprotein {ECO:0000256|RuleBase:RU364123};
KW Membrane {ECO:0000256|RuleBase:RU364123};
KW Prenylation {ECO:0000256|RuleBase:RU364123};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Transferase {ECO:0000313|EMBL:KYO27270.1}.
FT DOMAIN 42..871
FT /note="GH15-like"
FT /evidence="ECO:0000259|Pfam:PF00723"
FT DOMAIN 912..1069
FT /note="Phosphorylase b kinase regulatory subunit alpha/beta
FT C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19292"
SQ SEQUENCE 1086 AA; 124050 MW; 06B8E813123CB7A9 CRC64;
MANLDDDRAS SARAFSRFGS IYEPIKSINL PRPDGESLWD KLDHYYRIVK STVLLYQSPT
TGLFPTKTFG DNQKAKVHDS LYCAACAWAL ALAYRRIDDD KGRTHELEHS AIKCMRGILY
CYMRQADKVQ QFKQDPRPSK CLHSVFSAHT GDEVFSHEEY GHLQINAVSL FLLYLVEMIS
SGLQIIYNTD EVSFIQNLVF CVERAYRVPD FGVWERGSKY NNGSTDLHSS SVGLAKAALE
AINGFNLFGN QGCSWSVIFV DLDAHNRNRQ TLCSLLPRES RSHNTDAALL PCISYPAFAV
DDEALFNQTL DKVVRKLKGK YGLKRFLRDG YRTALEDKTR RYYKPAEIKL FDGIECEFPL
FFIFLMIDGV FRGNSEQVKE YQELLDSVLQ HTTEGHPVVP RYYYVPADFV ELEKKNPCSQ
KRFPSNSGRD GKLFLWGQAI YIIAKLLVDE LISPKDIDPV GRYIPLQDQR NISMRYSNQG
PLENDLVIHV ALIAESQRLQ VFLNTYGIQT QTPQQVEPIQ IWAQQELVKA YFHLGINDKL
GLSGRPDRPI GCLGTSKIYR ILGKTVVCYP IIFDLSDFYM SQDVMMLIDD IKNALQFIKQ
YWKMHGRPLF LVLIREDNIR GSRFNPILDM LADFKKGIIG GVKVHVDRVQ TLISGAVVEQ
LDFLRISESE PPVFNSLEEL ELPKHSKVKR QSSTPNVSEL EQQPEININD WKDRSTYEIL
QKLNDCNCLA SQALLLSVLL KREGSNFITK EGTVSDHIER IYRRAGSKKL WSVVRFAASL
LGKLVDSLAP SITNVLVQGK QVTLGAFGQE EEEVISNPLS PGVIKNIIYN NCNLQDEREA
VIQQELVIHI GWIISNSPEL FSGMLKIRVG WIIHAMKYEL KFRAGDMPAM DLYQLSPSEV
KQLLLDILQP QQQGRCWLNR RQIDGCLNRT PPGFYDRVWQ TLERTPNGLI VAEKYLPQQP
TLSDMTMYEM NFSLLVEDIL QNIDQPEYRQ IIVELLMVIS VVLERNPELE FQDKVDLDKL
VKEAFHGFQK DQVRLKGVEK QDDMTSFYNT PAIGKRGTCS YLTKAVMNLL LEGEMKPSSD
DPCTIS
//
