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Database: UniProt
Entry: A0A151MUT4_ALLMI
LinkDB: A0A151MUT4_ALLMI
Original site: A0A151MUT4_ALLMI 
ID   A0A151MUT4_ALLMI        Unreviewed;      4528 AA.
AC   A0A151MUT4;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   25-OCT-2017, entry version 8.
DE   SubName: Full=Ryanodine receptor 3 isoform D {ECO:0000313|EMBL:KYO28313.1};
GN   Name=RYR3 {ECO:0000313|EMBL:KYO28313.1};
GN   ORFNames=Y1Q_0015927 {ECO:0000313|EMBL:KYO28313.1};
OS   Alligator mississippiensis (American alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO28313.1};
RN   [1] {ECO:0000313|EMBL:KYO28313.1, ECO:0000313|Proteomes:UP000050525}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO28313.1};
RX   PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA   St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y.,
RA   Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A.,
RA   Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D.,
RA   Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J.,
RA   Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y.,
RA   Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E.,
RA   Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J.,
RA   Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W.,
RA   Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D.,
RA   Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.;
RT   "Sequencing three crocodilian genomes to illuminate the evolution of
RT   archosaurs and amniotes.";
RL   Genome Biol. 13:415-415(2012).
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KYO28313.1}.
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DR   EMBL; AKHW03004924; KYO28313.1; -; Genomic_DNA.
DR   Proteomes; UP000050525; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 3.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000050525};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:KYO28313.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3858   3880       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4070   4090       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4137   4156       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4329   4350       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4409   4432       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       84    139       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      146    191       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      199    253       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      259    316       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      327    384       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      569    780       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1009   1192       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1238   1451       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
SQ   SEQUENCE   4528 AA;  513558 MW;  1EDF4F4064B7DE30 CRC64;
     MDDEVVLQCV ANIHKEQRKF CLAAEGLGNR LCFLEPTSEA KYVPPDLCIC NFVLEQSLSV
     RALQEMLANT GDNASEGAAQ GGGHRTLLYG HAILLRHSFS GMYLTCLTTS RSQTDKLAFD
     VGLRENAAGE ACWWTIHPAS KQRSEGEKVR IGDDLILVSV SSERYLHLSM SNGNIQVDAS
     FMQTLWNVHP TCSGSSITEG FLLGGHVVRF FHGHDECLTI PSMDQNDLQQ KRVLYETGGA
     GVRARSLWRV EPLRISWSGS NIRWGQPFRL RHITTGEYLA LSEEEGLVML DREKSDTTST
     AFCFRASKEL KEKQDSSHKR DIDGMGVPEI KYGDSICFVQ HVASALWLTY KAQDAKTARL
     GPLKRKVILH QEGHMDDGLT LQRCQHEESQ AARIIRNTTS LFNQFISGNN RISAPIALPI
     EEMLQTLQDL ITYFQPPEEE LEHEDKQNKL RSLKNRQNLF KEEGMLALVL NCIDRLNDYN
     SAAHLVGVAR EVNGTAWKEI LNHLYKLLAA LIRGNRNNCT QFSGNLDWLI SKLDRLESSS
     GILEVLHCIL TESPEALNLI AEGHIKSIIS LLDKHGRNYK VLDVLCSLCL CNGVAVRANQ
     NLICDNLLPR RDLLLQTRLV NDVTSIRPNI FLGVAEGSAQ YKKWYFELII DQVDPFLTAE
     PTHLRVGWAS TSGYAPYPGG GEGWGGNGVG DDLFSYGFDG LHLWSGRVSR PVASVNQHLL
     ASDDVVSCCL DLGVPSISFR INGQPVQGMF ENFGTDGLFF PVVSFSAGVK VRFLLGGRHG
     EFKFLPPAGY APCYEALLPK EKMKLEPVKE YKRDFDGVRD LLGTTQFLSQ ASFIPCPIDT
     SQIVLPLHLE KIRDKLAENI HELWGMNKIE LGWTYGKVRD DNKRQHPCLV EFSKLPETEK
     NYNLQMSTET LKTLLALGCH IVHSNLAAEE DLKKVKLPKN YMMSNGYKPA PLDLSEVKLL
     PSQEVLVDKL AENAHNVWAK DRIKQGWTYG IQQDLKNKRN PRLVPYALLD ERTKKSNRDS
     LREAIRTFAG YGYNIEPPDQ EIADQAMQKV SIDKIRFFRV EQSYAVKTGK WYFEFEAVTG
     GDMRVGWARP GCRPDLELGA DDQAFVFEGS KGQRWHQGSG FFGRNWQPGD VVGCMINLDD
     KSMIFTLNGE LLITNKGSEL AFADFQLENG FVPICSLGLS QIGRMNLGMD ASTFKYYTMC
     GLQEGFEPFA VNMNRDVAMW FSKRLPTFVN VPKNHPHIEI TRIDGTIENP PRLKVTHRTF
     GTQNSNADMI YCRLSMPIEF HSSFNYNTGA ESASADAFQK RKQSQEIAVP STYYYSVRIF
     AGQDPSSVWV GWVTPDYHYY SENFDLNKNC TVTVTLGDER GRVHESVKRS NCYMVWGGDV
     TAHSQRSGRS NVDLEIGCLV DLATGMLSFT ANGKELGTCY QVEPNTKLFP AAFVQPTSTN
     LVQFELCKLK NTMPLSAAIF KSEEKNPVPQ CPPRLDVQTI TPVLWSRMPN SFLKVETERV
     SERHGWVVQC LEPLQMMALH IPEETRCVDI LELCEQEDLM MFHYHTLKLY CSVCALGNSR
     VAYALCSHVD ISQLFYTIDN QYLPGLLRSG FYDLLISIHL EHAKQAKLMM NNEFIIPITD
     ETRTIELYPD ETKKHGLPGV GLSTCLKPGY YFSTPCFIVT SDEHLKSSPE ISLDILKSKA
     ISMLTEAVHC SGTHIRDPVG GQVEFQFVPV LKLIGTLLIM GVFDDDDVKQ ILLLIDPNVF
     GEHKEETEEK TEKEEVTQIE EKAVEAGEKA IKETKAPIKG LLQTRLPESV KLQMCLLLNY
     FCDCELQHRV ESIVSFADNY VSKLQYNQRF RYNELMQALN MSAALTAKKT KEFRSPAQEQ
     INMLLNFQLG EDCPCPEEIR DELYEFHDDL LIHCATLKQL ISQTMVRWAQ EDQMQDSELV
     RIMYTLLRRQ YDSIGELLQA LRKAYTISAA SVQDTINLLA ALGQIRSLLS VRMGKEEELL
     MINGLGDIMN NKVFYQHPNL MRVLGMHETV MDVMVNVLGG DKSQRIIFPK MVASCCRFLC
     YFCRISRQNQ KAMFEHLSYL LENSSVGLAF PSMRGSTPLD VAAASVMDNN ELALALEEPD
     LEKVVTYLAG CGLQSCPVLL AKGYPDIGWN PIEGERYLTF LRFAVFVNSE SVEENASVVV
     KLLIRRPECF GPDLRGEGGN GLLAAMQEAI NISENPARDL PSQGYKREGA AEDEEEEEIV
     HMGNAIMSFY SALIDLLGRC APEMHLIQSG KGEAIRIRSI LRSLVPTEDL VGIISIPLKL
     STVNKDGTVN EPDMSASFCP DHKAPMVLFL DRVYGIKDQS FLLHLLEVGF LPDLRASASL
     DTVSLSTTEA ALALNRYICS AVFPLLKRCA PLFSGTEHYA SLIDSTLHTI YRLSKGRSLT
     KAQRDTIEEC LLAVCHHLRP SMLQQLLRRL VFDVPLLNEY CKMPLKLLTN HYEQCWKYYC
     LPSGMGSYGI AAEEELHLTE KLFWGIFDSL SHKFLSLLQK YDPELFRMAL PCLSAIAGAL
     PPDYLDTRIR ATLEKQTSLD PEGNFDPKPI NTVNLALPEK LEYIVSKYAE HSHDKWAFDK
     TNSGWKYGVS LDENMKTHPL IRPFKTLTEK EKEIYRWPAR ESLKTMLAMG WRLERTKEGE
     AMVQQRENEK LRSISQSSQG NGYSPAPLDL SNVVLSRELQ GMVEVMAENY HNIWAKKKKM
     ELESKGGGSH PLLVPYDTLT AKEKSRDREK AQELFKFLQV NGIVISRGLN DMELDASSME
     KRFAFKFLKK ILKYVDSAQE FIAHLEAIVT SGKTEKSPHD QEIKFFAKVL LPLVDQYFTN
     HCLYFLSSPI KSLSSSGYAS NKEKEMVASL FCKLAALVRH RISLFGSDAT TVVSCLHILA
     QSLDTRTVMK SGSELVKAGL RAFFENAAED LEKTSENLKL GKFTHSRTQI KGVSQNINYT
     TVALLPILTS MFEHIAQHHF GVDLLLGDVQ VSCYRILCSL YSLGTGKNIY VERQCPALGE
     CLASLAAAIP VAFLEPSLNR YNPLSVFNTK TARERAILGM PDTVEEMCPE IPHLDGLMRE
     INGLAESGAR YTEMPHVIEV ILPMLCNYLS YWWEKGPESM PISAGPCCTM ITSEHLSIIL
     GNILKIINNN LGIDEASWMK RIAVYAQPII SKARPDLLKT HFIPTLEKLK KKAIKIVIEE
     EQLRADSKTD TQEAELLILD EFAVLCRDLY AFYPMLIRYV DNNRANWLKK PDADSVELFR
     MVAEVFILWC KSHNFKREEQ NFVIQNEINN LAFLTGDSKS KMSKSGGQDQ ERKKSKRRGD
     LYSIQTSLIV AALKKMLPIG LNMCTPGDQE LISLAKIRYS HRDTDEEVKE HLLNNLHLQE
     KSEDPAVKWQ LNLYKDIMKS DEPPDPEKTV ERVQRISAAL FHLEQVEQPL RSKKAVWHKL
     LSKQRKRAVV ACFRMAPLYN LPRHKISNFF LSTFQRVWLE KVHEKTQYDR LILMLTTPPR
     KEEEEEEETE KKHPDPLHQI ILYFSHNALT ERSKLEDDAL YISYSAMMAK EKEMEKQKTL
     YQQARLHDRG AAEMVLQMIS ASKGKMGLMV IETLKLGIAI LNGGNTIVQQ KMLDYLKEKK
     DAGFFQSLSG LMQSCSVLDL NAFERQNKAE GLGMVTEEGT REKVLQYDEF TRDLFRFLQL
     LCEGHNNDFQ NYLRTQMGNT TTVNIIISTV DYLLRLQESI SDFYWYYSGK DVIDDSGQRN
     FSKALAVTKQ IFNSLTEYIQ GPCIGNQQSL AHSRLWDAVV GFLHVFANMQ MKLSQDSSQI
     ELLKELLDLL QDMVVMLLSL LEGNVVNGTI GKQMVDTLVE SSSNVEMILK FFDMFLKLKD
     LTNSDAFKEY DPDGLFQLFF TIVWGIFQIL WSTVFGGGLV EGAKNIKVTK ILGDMPDPTQ
     FGIHDDVMET EKAEGVEHGI RAELVQFVKG EKGETDIMSD IFGIRTKKEG GSKYSHDAGL
     GDIKEIIGSD SPSSLENAVR KKKRAQTSEI AKEVEMEIKT ESEKADMEDG EKQDKAKEIQ
     SEHLEEGKMK KKKRRRGQKI EKPEAVMANF VKALEVYQTK MLHCLARNFY NLRFLALFVA
     FAINFILLFY KVTEEPLDEV EEDSNLWNSF DEDEEEEGMV FFVLEESTGY MAPTLRGLAI
     IHTVISFVCV IGYYCLKVPL VVFKREKEVA RKLEFDGLYI TEQPSEDDIK GQWDRLVINT
     PSFPNNYWDK FVKRKVINKY GDLYGADRIA ELLGLDKNAL DFSPVEETEP DEASLVSWLS
     SIDTKYHIWK LGVVFTDNSF LYLAWYTTMS ILGHYNNFFF AAHLLDIAMG FKTLRTILSS
     VTHNGKQLVL TVGLLAVVVY LYTVVAFNFF RKFYNKSEDE DEPDMKCDDM MTCYLFHMYV
     GVRAGGGIGD EIEDPAGDPY EMYRIVFDIT FFFFVIVILL AIIQGLIIDA FGELRDQQEQ
     VREDMETKCF ICGIGNDYFD TTPHGFETHT LQEHNLANYL FFLMYLINKD ETEHTGQESF
     VWKMYQERCW DFFPAGDCFR KQYEDQLG
//
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