ID A0A151MUV1_ALLMI Unreviewed; 716 AA.
AC A0A151MUV1;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Protein-glutamine gamma-glutamyltransferase E isoform A {ECO:0000313|EMBL:KYO28282.1};
GN Name=TGM3 {ECO:0000313|EMBL:KYO28282.1};
GN ORFNames=Y1Q_0021981 {ECO:0000313|EMBL:KYO28282.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO28282.1};
RN [1] {ECO:0000313|EMBL:KYO28282.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO28282.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|PIRSR:PIRSR000459-2};
CC Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR000459-2};
CC -!- SIMILARITY: Belongs to the transglutaminase superfamily.
CC Transglutaminase family. {ECO:0000256|ARBA:ARBA00005968}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO28282.1}.
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DR EMBL; AKHW03004933; KYO28282.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151MUV1; -.
DR eggNOG; ENOG502QQ46; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR002931; Transglutaminase-like.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR InterPro; IPR023608; Transglutaminase_animal.
DR InterPro; IPR013808; Transglutaminase_AS.
DR InterPro; IPR008958; Transglutaminase_C.
DR InterPro; IPR036238; Transglutaminase_C_sf.
DR InterPro; IPR001102; Transglutaminase_N.
DR PANTHER; PTHR11590; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE; 1.
DR PANTHER; PTHR11590:SF50; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 6; 1.
DR Pfam; PF00927; Transglut_C; 1.
DR Pfam; PF01841; Transglut_core; 1.
DR Pfam; PF00868; Transglut_N; 1.
DR PIRSF; PIRSF000459; TGM_EBP42; 2.
DR SMART; SM00460; TGc; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49309; Transglutaminase, two C-terminal domains; 2.
DR PROSITE; PS00547; TRANSGLUTAMINASES; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PIRSR:PIRSR000459-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000459-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Transferase {ECO:0000313|EMBL:KYO28282.1}.
FT DOMAIN 266..358
FT /note="Transglutaminase-like"
FT /evidence="ECO:0000259|SMART:SM00460"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 274
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT ACT_SITE 332
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT ACT_SITE 355
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT BINDING 395
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 397
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 444
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 449
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
SQ SEQUENCE 716 AA; 80140 MW; BFB74925E816AD8A CRC64;
MEALTPTHIS WQPSANTSAH RTNRYAHKQL IVRRGQGFTI TLYFNRPQQS GDSLAFISET
GPSPSEGSRT RAVFNVSSAG ASGWSASQGP SESNYTNFTL CSPANAAIGR YNLSLQITCG
NQVSSRFLGQ FVLLFNPWCP DDEVHMADEG ERQEYTLNEN GIIFVGNAKY IQARGWYYGQ
FQDRILNICL TMLDLSLYYR QNPAADVARR GDPKYVGRVL SSMINGNDND NGVLLGNWQG
NFTEYENPSR WEGSVVILHK WLQDNYRPVQ YGQCWVFAGV MCTALRCLGI PNRLITNFNS
AHDSDRNLSV DKYYDPYGRS LQIGKDSSWD YHVWNEGWFI RTDLGSSYNG WQVLDSTPQE
PSKGIFQCGP ASVVAVKQGD VDLSYDTLFV FSEVNADSNR WIVYGDGTKK RVYCDTEVFG
RSISTKAVGS NARVDVTNNY KYPEGSPEER QVYRKAWNKI FGSNTTERRP EVLNERSTDA
ARNPGIAGRF KLVEPPVLGH DISLILILNN LSSEHKSVKV NMSASSILYT RRTVAEILQE
TASVELGANA EKHILLKFPY SRYGKHLTDD KRILVTGLCE VMNMPGVKFL VEKTIMLENP
KIIIKVPSQI VVNRAVNLEI WYTNPLPEPV ENCVLLATLM NQQVKINVAG LAPKEQSMIY
YEFTPRQTAI KRKEIIYSSN KKTGKSISTK AVAATPARVS LTATSIPEIL SVVSGI
//
