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Database: UniProt
Entry: A0A151MUW4_ALLMI
LinkDB: A0A151MUW4_ALLMI
Original site: A0A151MUW4_ALLMI 
ID   A0A151MUW4_ALLMI        Unreviewed;      4463 AA.
AC   A0A151MUW4;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   20-DEC-2017, entry version 10.
DE   SubName: Full=Ryanodine receptor 3 isoform A {ECO:0000313|EMBL:KYO28310.1};
GN   Name=RYR3 {ECO:0000313|EMBL:KYO28310.1};
GN   ORFNames=Y1Q_0015927 {ECO:0000313|EMBL:KYO28310.1};
OS   Alligator mississippiensis (American alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO28310.1};
RN   [1] {ECO:0000313|EMBL:KYO28310.1, ECO:0000313|Proteomes:UP000050525}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO28310.1};
RX   PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA   St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y.,
RA   Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A.,
RA   Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D.,
RA   Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J.,
RA   Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y.,
RA   Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E.,
RA   Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J.,
RA   Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W.,
RA   Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D.,
RA   Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.;
RT   "Sequencing three crocodilian genomes to illuminate the evolution of
RT   archosaurs and amniotes.";
RL   Genome Biol. 13:415-415(2012).
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KYO28310.1}.
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DR   EMBL; AKHW03004924; KYO28310.1; -; Genomic_DNA.
DR   Proteomes; UP000050525; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 3.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000050525};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:KYO28310.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3793   3815       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4005   4025       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4072   4091       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4264   4285       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4344   4367       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       20     75       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN       82    127       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      135    189       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      195    252       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      263    320       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      505    716       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      945   1128       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1174   1387       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED      379    399       {ECO:0000256|SAM:Coils}.
FT   COILED     3102   3122       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4463 AA;  506453 MW;  31093CFECE40AE26 CRC64;
     MVLILSKETN KQKAAQGGGH RTLLYGHAIL LRHSFSGMYL TCLTTSRSQT DKLAFDVGLR
     ENAAGEACWW TIHPASKQRS EGEKVRIGDD LILVSVSSER YLHLSMSNGN IQVDASFMQT
     LWNVHPTCSG SSITEGFLLG GHVVRFFHGH DECLTIPSMD QNDLQQKRVL YETGGAGVRA
     RSLWRVEPLR ISWSGSNIRW GQPFRLRHIT TGEYLALSEE EGLVMLDREK SDTTSTAFCF
     RASKELKEKQ DSSHKRDIDG MGVPEIKYGD SICFVQHVAS ALWLTYKAQD AKTARLGPLK
     RKVILHQEGH MDDGLTLQRC QHEESQAARI IRNTTSLFNQ FISGNNRISA PIALPIEEML
     QTLQDLITYF QPPEEELEHE DKQNKLRSLK NRQNLFKEEG MLALVLNCID RLNDYNSAAH
     LVGVAREVNG TAWKEILNHL YKLLAALIRG NRNNCTQFSG NLDWLISKLD RLESSSGILE
     VLHCILTESP EALNLIAEGH IKSIISLLDK HGRNYKVLDV LCSLCLCNGV AVRANQNLIC
     DNLLPRRDLL LQTRLVNDVT SIRPNIFLGV AEGSAQYKKW YFELIIDQVD PFLTAEPTHL
     RVGWASTSGY APYPGGGEGW GGNGVGDDLF SYGFDGLHLW SGRVSRPVAS VNQHLLASDD
     VVSCCLDLGV PSISFRINGQ PVQGMFENFG TDGLFFPVVS FSAGVKVRFL LGGRHGEFKF
     LPPAGYAPCY EALLPKEKMK LEPVKEYKRD FDGVRDLLGT TQFLSQASFI PCPIDTSQIV
     LPLHLEKIRD KLAENIHELW GMNKIELGWT YGKVRDDNKR QHPCLVEFSK LPETEKNYNL
     QMSTETLKTL LALGCHIVHS NLAAEEDLKK VKLPKNYMMS NGYKPAPLDL SEVKLLPSQE
     VLVDKLAENA HNVWAKDRIK QGWTYGIQQD LKNKRNPRLV PYALLDERTK KSNRDSLREA
     IRTFAGYGYN IEPPDQEIAD QAMQKVSIDK IRFFRVEQSY AVKTGKWYFE FEAVTGGDMR
     VGWARPGCRP DLELGADDQA FVFEGSKGQR WHQGSGFFGR NWQPGDVVGC MINLDDKSMI
     FTLNGELLIT NKGSELAFAD FQLENGFVPI CSLGLSQIGR MNLGMDASTF KYYTMCGLQE
     GFEPFAVNMN RDVAMWFSKR LPTFVNVPKN HPHIEITRID GTIENPPRLK VTHRTFGTQN
     SNADMIYCRL SMPIEFHSSF NYNTGAESAS ADAFQKRKQS QEIAVPSTYY YSVRIFAGQD
     PSSVWVGWVT PDYHYYSENF DLNKNCTVTV TLGDERGRVH ESVKRSNCYM VWGGDVTAHS
     QRSGRSNVDL EIGCLVDLAT GMLSFTANGK ELGTCYQVEP NTKLFPAAFV QPTSTNLVQF
     ELCKLKNTMP LSAAIFKSEE KNPVPQCPPR LDVQTITPVL WSRMPNSFLK VETERVSERH
     GWVVQCLEPL QMMALHIPEE TRCVDILELC EQEDLMMFHY HTLKLYCSVC ALGNSRVAYA
     LCSHVDISQL FYTIDNQYLP GLLRSGFYDL LISIHLEHAK QAKLMMNNEF IIPITDETRT
     IELYPDETKK HGLPGVGLST CLKPGYYFST PCFIVTSDEH LKSSPEISLD ILKSKAISML
     TEAVHCSGTH IRDPVGGQVE FQFVPVLKLI GTLLIMGVFD DDDVKQILLL IDPNVFGEHK
     EETEEKTEKE EVTQIEEKAV EAGEKAIKET KAPIKGLLQT RLPESVKLQM CLLLNYFCDC
     ELQHRVESIV SFADNYVSKL QYNQRFRYNE LMQALNMSAA LTAKKTKEFR SPAQEQINML
     LNFQLGEDCP CPEEIRDELY EFHDDLLIHC ATLKQLISQT MVRWAQEDQM QDSELVRIMY
     TLLRRQYDSI GELLQALRKA YTISAASVQD TINLLAALGQ IRSLLSVRMG KEEELLMING
     LGDIMNNKVF YQHPNLMRVL GMHETVMDVM VNVLGGDKSQ RIIFPKMVAS CCRFLCYFCR
     ISRQNQKAMF EHLSYLLENS SVGLAFPSMR GSTPLDVAAA SVMDNNELAL ALEEPDLEKV
     VTYLAGCGLQ SCPVLLAKGY PDIGWNPIEG ERYLTFLRFA VFVNSESVEE NASVVVKLLI
     RRPECFGPDL RGEGGNGLLA AMQEAINISE NPARDLPSQG YKREGAAEDE EEEEIVHMGN
     AIMSFYSALI DLLGRCAPEM HLIQSGKGEA IRIRSILRSL VPTEDLVGII SIPLKLSTVN
     KDGTVNEPDM SASFCPDHKA PMVLFLDRVY GIKDQSFLLH LLEVGFLPDL RASASLDTVS
     LSTTEAALAL NRYICSAVFP LLKRCAPLFS GTEHYASLID STLHTIYRLS KGRSLTKAQR
     DTIEECLLAV CHHLRPSMLQ QLLRRLVFDV PLLNEYCKMP LKLLTNHYEQ CWKYYCLPSG
     MGSYGIAAEE ELHLTEKLFW GIFDSLSHKF LSLLQKYDPE LFRMALPCLS AIAGALPPDY
     LDTRIRATLE KQTSLDPEGN FDPKPINTVN LALPEKLEYI VSKYAEHSHD KWAFDKTNSG
     WKYGVSLDEN MKTHPLIRPF KTLTEKEKEI YRWPARESLK TMLAMGWRLE RTKEGEAMVQ
     QRENEKLRSI SQSSQGNGYS PAPLDLSNVV LSRELQGMVE VMAENYHNIW AKKKKMELES
     KGGGSHPLLV PYDTLTAKEK SRDREKAQEL FKFLQVNGIV ISRGLNDMEL DASSMEKRFA
     FKFLKKILKY VDSAQEFIAH LEAIVTSGKT EKSPHDQEIK FFAKVLLPLV DQYFTNHCLY
     FLSSPIKSLS SSGYASNKEK EMVASLFCKL AALVRHRISL FGSDATTVVS CLHILAQSLD
     TRTVMKSGSE LVKAGLRAFF ENAAEDLEKT SENLKLGKFT HSRTQIKGVS QNINYTTVAL
     LPILTSMFEH IAQHHFGVDL LLGDVQVSCY RILCSLYSLG TGKNIYVERQ CPALGECLAS
     LAAAIPVAFL EPSLNRYNPL SVFNTKTARE RAILGMPDTV EEMCPEIPHL DGLMREINGL
     AESGARYTEM PHVIEVILPM LCNYLSYWWE KGPESMPISA GPCCTMITSE HLSIILGNIL
     KIINNNLGID EASWMKRIAV YAQPIISKAR PDLLKTHFIP TLEKLKKKAI KIVIEEEQLR
     ADSKTDTQEA ELLILDEFAV LCRDLYAFYP MLIRYVDNNR ANWLKKPDAD SVELFRMVAE
     VFILWCKSHN FKREEQNFVI QNEINNLAFL TGDSKSKMSK SGGQDQERKK SKRRGDLYSI
     QTSLIVAALK KMLPIGLNMC TPGDQELISL AKIRYSHRDT DEEVKEHLLN NLHLQEKSED
     PAVKWQLNLY KDIMKSDEPP DPEKTVERVQ RISAALFHLE QVEQPLRSKK AVWHKLLSKQ
     RKRAVVACFR MAPLYNLPRH RSINLFLHGY QNYWIETEEY SFEEKLVQDL ATPPRKEEEE
     EEETEKKHPD PLHQIILYFS HNALTERSKL EDDALYISYS AMMAKEKEME KQKTLYQQAR
     LHDRGAAEMV LQMISASKGK MGLMVIETLK LGIAILNGGN TIVQQKMLDY LKEKKDAGFF
     QSLSGLMQSC SVLDLNAFER QNKAEGLGMV TEEGTREKVL QYDEFTRDLF RFLQLLCEGH
     NNDFQNYLRT QMGNTTTVNI IISTVDYLLR LQESISDFYW YYSGKDVIDD SGQRNFSKAL
     AVTKQIFNSL TEYIQGPCIG NQQSLAHSRL WDAVVGFLHV FANMQMKLSQ DSSQIELLKE
     LLDLLQDMVV MLLSLLEGNV VNGTIGKQMV DTLVESSSNV EMILKFFDMF LKLKDLTNSD
     AFKEYDPDGL FQLFFTIVWG IFQILWSTVF GGGLVEGAKN IKVTKILGDM PDPTQFGIHD
     DVMETEKAEG VEHGIRAELV QFVKGEKGET DIMSDIFGIR TKKEGGSKYS HDAGLGDIKE
     IIGSDSPSSL ENAVRKKKRA QTSEIAKEVE MEIKTESEKA DMEDGEKQDK AKEIQSEHLE
     EGKMKKKKRR RGQKIEKPEA VMANFVKALE VYQTKMLHCL ARNFYNLRFL ALFVAFAINF
     ILLFYKVTEE PLDEVEEDSN LWNSFDEDEE EEGMVFFVLE ESTGYMAPTL RGLAIIHTVI
     SFVCVIGYYC LKVPLVVFKR EKEVARKLEF DGLYITEQPS EDDIKGQWDR LVINTPSFPN
     NYWDKFVKRK VINKYGDLYG ADRIAELLGL DKNALDFSPV EETEPDEASL VSWLSSIDTK
     YHIWKLGVVF TDNSFLYLAW YTTMSILGHY NNFFFAAHLL DIAMGFKTLR TILSSVTHNG
     KQLVLTVGLL AVVVYLYTVV AFNFFRKFYN KSEDEDEPDM KCDDMMTCYL FHMYVGVRAG
     GGIGDEIEDP AGDPYEMYRI VFDITFFFFV IVILLAIIQG LIIDAFGELR DQQEQVREDM
     ETKCFICGIG NDYFDTTPHG FETHTLQEHN LANYLFFLMY LINKDETEHT GQESFVWKMY
     QERCWDFFPA GDCFRKQYED QLG
//
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