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Database: UniProt
Entry: A0A151MV07_ALLMI
LinkDB: A0A151MV07_ALLMI
Original site: A0A151MV07_ALLMI 
ID   A0A151MV07_ALLMI        Unreviewed;      4559 AA.
AC   A0A151MV07;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   25-OCT-2017, entry version 8.
DE   SubName: Full=Ryanodine receptor 3 isoform E {ECO:0000313|EMBL:KYO28314.1};
GN   Name=RYR3 {ECO:0000313|EMBL:KYO28314.1};
GN   ORFNames=Y1Q_0015927 {ECO:0000313|EMBL:KYO28314.1};
OS   Alligator mississippiensis (American alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO28314.1};
RN   [1] {ECO:0000313|EMBL:KYO28314.1, ECO:0000313|Proteomes:UP000050525}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO28314.1};
RX   PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA   St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y.,
RA   Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A.,
RA   Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D.,
RA   Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J.,
RA   Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y.,
RA   Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E.,
RA   Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J.,
RA   Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W.,
RA   Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D.,
RA   Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.;
RT   "Sequencing three crocodilian genomes to illuminate the evolution of
RT   archosaurs and amniotes.";
RL   Genome Biol. 13:415-415(2012).
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KYO28314.1}.
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DR   EMBL; AKHW03004924; KYO28314.1; -; Genomic_DNA.
DR   Proteomes; UP000050525; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 3.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000050525};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:KYO28314.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3889   3911       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4101   4121       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4168   4187       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4360   4381       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4440   4463       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       84    139       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      146    191       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      199    253       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      259    316       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      327    384       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      569    780       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1009   1192       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1238   1451       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
SQ   SEQUENCE   4559 AA;  517153 MW;  D09AFC4E61A17117 CRC64;
     MDDEVVLQCV ANIHKEQRKF CLAAEGLGNR LCFLEPTSEA KYVPPDLCIC NFVLEQSLSV
     RALQEMLANT GDNASEGAAQ GGGHRTLLYG HAILLRHSFS GMYLTCLTTS RSQTDKLAFD
     VGLRENAAGE ACWWTIHPAS KQRSEGEKVR IGDDLILVSV SSERYLHLSM SNGNIQVDAS
     FMQTLWNVHP TCSGSSITEG FLLGGHVVRF FHGHDECLTI PSMDQNDLQQ KRVLYETGGA
     GVRARSLWRV EPLRISWSGS NIRWGQPFRL RHITTGEYLA LSEEEGLVML DREKSDTTST
     AFCFRASKEL KEKQDSSHKR DIDGMGVPEI KYGDSICFVQ HVASALWLTY KAQDAKTARL
     GPLKRKVILH QEGHMDDGLT LQRCQHEESQ AARIIRNTTS LFNQFISGNN RISAPIALPI
     EEMLQTLQDL ITYFQPPEEE LEHEDKQNKL RSLKNRQNLF KEEGMLALVL NCIDRLNDYN
     SAAHLVGVAR EVNGTAWKEI LNHLYKLLAA LIRGNRNNCT QFSGNLDWLI SKLDRLESSS
     GILEVLHCIL TESPEALNLI AEGHIKSIIS LLDKHGRNYK VLDVLCSLCL CNGVAVRANQ
     NLICDNLLPR RDLLLQTRLV NDVTSIRPNI FLGVAEGSAQ YKKWYFELII DQVDPFLTAE
     PTHLRVGWAS TSGYAPYPGG GEGWGGNGVG DDLFSYGFDG LHLWSGRVSR PVASVNQHLL
     ASDDVVSCCL DLGVPSISFR INGQPVQGMF ENFGTDGLFF PVVSFSAGVK VRFLLGGRHG
     EFKFLPPAGY APCYEALLPK EKMKLEPVKE YKRDFDGVRD LLGTTQFLSQ ASFIPCPIDT
     SQIVLPLHLE KIRDKLAENI HELWGMNKIE LGWTYGKVRD DNKRQHPCLV EFSKLPETEK
     NYNLQMSTET LKTLLALGCH IVHSNLAAEE DLKKVKLPKN YMMSNGYKPA PLDLSEVKLL
     PSQEVLVDKL AENAHNVWAK DRIKQGWTYG IQQDLKNKRN PRLVPYALLD ERTKKSNRDS
     LREAIRTFAG YGYNIEPPDQ EIADQAMQKV SIDKIRFFRV EQSYAVKTGK WYFEFEAVTG
     GDMRVGWARP GCRPDLELGA DDQAFVFEGS KGQRWHQGSG FFGRNWQPGD VVGCMINLDD
     KSMIFTLNGE LLITNKGSEL AFADFQLENG FVPICSLGLS QIGRMNLGMD ASTFKYYTMC
     GLQEGFEPFA VNMNRDVAMW FSKRLPTFVN VPKNHPHIEI TRIDGTIENP PRLKVTHRTF
     GTQNSNADMI YCRLSMPIEF HSSFNYNTGA ESASADAFQK RKQSQEIAVP STYYYSVRIF
     AGQDPSSVWV GWVTPDYHYY SENFDLNKNC TVTVTLGDER GRVHESVKRS NCYMVWGGDV
     TAHSQRSGRS NVDLEIGCLV DLATGMLSFT ANGKELGTCY QVEPNTKLFP AAFVQPTSTN
     LVQFELCKLK NTMPLSAAIF KSEEKNPVPQ CPPRLDVQTI TPVLWSRMPN SFLKVETERV
     SERHGWVVQC LEPLQMMALH IPEETRCVDI LELCEQEDLM MFHYHTLKLY CSVCALGNSR
     VAYALCSHVD ISQLFYTIDN QYLPGLLRSG FYDLLISIHL EHAKQAKLMM NNEFIIPITD
     ETRTIELYPD ETKKHGLPGV GLSTCLKPGY YFSTPCFIVT SDEHLKSSPE ISLDILKSKA
     ISMLTEAVHC SGTHIRDPVG GQVEFQFVPV LKLIGTLLIM GVFDDDDVKQ ILLLIDPNVF
     GEHKEETEEK TEKEEVTQIE EKAVEAGEKA IKETKAPIKG LLQTRLPESV KLQMCLLLNY
     FCDCELQHRV ESIVSFADNY VSKLQYNQRF RYNELMQALN MSAALTAKKT KEFRSPAQEQ
     INMLLNFQLG EDCPCPEEIR DELYEFHDDL LIHCATLKQL ISQTMVRWAQ EDQMQDSELV
     RIMYTLLRRQ YDSIGELLQA LRKAYTISAA SVQDTINLLA ALGQIRSLLS VRMGKEEELL
     MINGLGDIMN NKVFYQHPNL MRVLGMHETV MDVMVNVLGG DKSQRIIFPK MVASCCRFLC
     YFCRISRQNQ KAMFEHLSYL LENSSVGLAF PSMRGSTPLD VAAASVMDNN ELALALEEPD
     LEKVVTYLAG CGLQSCPVLL AKGYPDIGWN PIEGERYLTF LRFAVFVNMP PTQKRWTSSL
     IRTTFMLRPC FASWDTSRCS GESVEENASV VVKLLIRRPE CFGPDLRGEG GNGLLAAMQE
     AINISENPAR DLPSQGYKRE GAAEDEEEEE IVHMGNAIMS FYSALIDLLG RCAPEMHLIQ
     SGKGEAIRIR SILRSLVPTE DLVGIISIPL KLSTVNKDGT VNEPDMSASF CPDHKAPMVL
     FLDRVYGIKD QSFLLHLLEV GFLPDLRASA SLDTVSLSTT EAALALNRYI CSAVFPLLKR
     CAPLFSGTEH YASLIDSTLH TIYRLSKGRS LTKAQRDTIE ECLLAVCHHL RPSMLQQLLR
     RLVFDVPLLN EYCKMPLKLL TNHYEQCWKY YCLPSGMGSY GIAAEEELHL TEKLFWGIFD
     SLSHKFLSLL QKYDPELFRM ALPCLSAIAG ALPPDYLDTR IRATLEKQTS LDPEGNFDPK
     PINTVNLALP EKLEYIVSKY AEHSHDKWAF DKTNSGWKYG VSLDENMKTH PLIRPFKTLT
     EKEKEIYRWP ARESLKTMLA MGWRLERTKE GEAMVQQREN EKLRSISQSS QGNGYSPAPL
     DLSNVVLSRE LQGMVEVMAE NYHNIWAKKK KMELESKGGG SHPLLVPYDT LTAKEKSRDR
     EKAQELFKFL QVNGIVISRG LNDMELDASS MEKRFAFKFL KKILKYVDSA QEFIAHLEAI
     VTSGKTEKSP HDQEIKFFAK VLLPLVDQYF TNHCLYFLSS PIKSLSSSGY ASNKEKEMVA
     SLFCKLAALV RHRISLFGSD ATTVVSCLHI LAQSLDTRTV MKSGSELVKA GLRAFFENAA
     EDLEKTSENL KLGKFTHSRT QIKGVSQNIN YTTVALLPIL TSMFEHIAQH HFGVDLLLGD
     VQVSCYRILC SLYSLGTGKN IYVERQCPAL GECLASLAAA IPVAFLEPSL NRYNPLSVFN
     TKTARERAIL GMPDTVEEMC PEIPHLDGLM REINGLAESG ARYTEMPHVI EVILPMLCNY
     LSYWWEKGPE SMPISAGPCC TMITSEHLSI ILGNILKIIN NNLGIDEASW MKRIAVYAQP
     IISKARPDLL KTHFIPTLEK LKKKAIKIVI EEEQLRADSK TDTQEAELLI LDEFAVLCRD
     LYAFYPMLIR YVDNNRANWL KKPDADSVEL FRMVAEVFIL WCKSHNFKRE EQNFVIQNEI
     NNLAFLTGDS KSKMSKSGGQ DQERKKSKRR GDLYSIQTSL IVAALKKMLP IGLNMCTPGD
     QELISLAKIR YSHRDTDEEV KEHLLNNLHL QEKSEDPAVK WQLNLYKDIM KSDEPPDPEK
     TVERVQRISA ALFHLEQVEQ PLRSKKAVWH KLLSKQRKRA VVACFRMAPL YNLPRHRSIN
     LFLHGYQNYW IETEEYSFEE KLVQDLATPP RKEEEEEEET EKKHPDPLHQ IILYFSHNAL
     TERSKLEDDA LYISYSAMMA KEKEMEKQKT LYQQARLHDR GAAEMVLQMI SASKGKMGLM
     VIETLKLGIA ILNGGNTIVQ QKMLDYLKEK KDAGFFQSLS GLMQSCSVLD LNAFERQNKA
     EGLGMVTEEG TREKVLQYDE FTRDLFRFLQ LLCEGHNNDF QNYLRTQMGN TTTVNIIIST
     VDYLLRLQES ISDFYWYYSG KDVIDDSGQR NFSKALAVTK QIFNSLTEYI QGPCIGNQQS
     LAHSRLWDAV VGFLHVFANM QMKLSQDSSQ IELLKELLDL LQDMVVMLLS LLEGNVVNGT
     IGKQMVDTLV ESSSNVEMIL KFFDMFLKLK DLTNSDAFKE YDPDGLFQLF FTIVWGIFQI
     LWSTVFGGGL VEGAKNIKVT KILGDMPDPT QFGIHDDVME TEKAEGVEHG IRAELVQFVK
     GEKGETDIMS DIFGIRTKKE GGSKYSHDAG LGDIKEIIGS DSPSSLENAV RKKKRAQTSE
     IAKEVEMEIK TESEKADMED GEKQDKAKEI QSEHLEEGKM KKKKRRRGQK IEKPEAVMAN
     FVKALEVYQT KMLHCLARNF YNLRFLALFV AFAINFILLF YKVTEEPLDE VEEDSNLWNS
     FDEDEEEEGM VFFVLEESTG YMAPTLRGLA IIHTVISFVC VIGYYCLKVP LVVFKREKEV
     ARKLEFDGLY ITEQPSEDDI KGQWDRLVIN TPSFPNNYWD KFVKRKVINK YGDLYGADRI
     AELLGLDKNA LDFSPVEETE PDEASLVSWL SSIDTKYHIW KLGVVFTDNS FLYLAWYTTM
     SILGHYNNFF FAAHLLDIAM GFKTLRTILS SVTHNGKQLV LTVGLLAVVV YLYTVVAFNF
     FRKFYNKSED EDEPDMKCDD MMTCYLFHMY VGVRAGGGIG DEIEDPAGDP YEMYRIVFDI
     TFFFFVIVIL LAIIQGLIID AFGELRDQQE QVREDMETKC FICGIGNDYF DTTPHGFETH
     TLQEHNLANY LFFLMYLINK DETEHTGQES FVWKMYQERC WDFFPAGDCF RKQYEDQLG
//
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