ID A0A151MVH9_ALLMI Unreviewed; 694 AA.
AC A0A151MVH9;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=N-acetylated-alpha-linked acidic dipeptidase 2 {ECO:0000313|EMBL:KYO28530.1};
GN Name=NAALAD2 {ECO:0000313|EMBL:KYO28530.1};
GN ORFNames=Y1Q_0005330 {ECO:0000313|EMBL:KYO28530.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO28530.1};
RN [1] {ECO:0000313|EMBL:KYO28530.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO28530.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane
CC protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC {ECO:0000256|ARBA:ARBA00005634}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO28530.1}.
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DR EMBL; AKHW03004889; KYO28530.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151MVH9; -.
DR STRING; 8496.A0A151MVH9; -.
DR eggNOG; KOG2195; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd08022; M28_PSMA_like; 1.
DR CDD; cd02121; PA_GCPII_like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR007365; TFR-like_dimer_dom.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR PANTHER; PTHR10404:SF38; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE 2; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR Pfam; PF04253; TFR_dimer; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022968}.
FT DOMAIN 116..203
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 301..504
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT DOMAIN 571..691
FT /note="Transferrin receptor-like dimerisation"
FT /evidence="ECO:0000259|Pfam:PF04253"
SQ SEQUENCE 694 AA; 78546 MW; 812A5C80969419ED CRC64;
MRQKLVAEMK AENIKEFLRS FTKLPHLAGT EQNFHLAKQI QDQWKSFGLD SAELVHYDVL
LSYPNETKPN YISIIDDLGN EIFNTSLFEP PPQGYENITG MLPPYNAFSA QGTPEADLVY
VNYGRTEDFF KLERELGINC TGKIVIARYG KIFRGNKVKN AILAGARGVI LYSDPADYCA
SGVDPYPKGW NLPGGGAQRG NVLNLNGAGD PLTPGYPAKE YTFRYEVDEG VGIPVIPVHP
IGYYDAEILL RIMGGPAAPD DSWMGSLSVP YNVGPGFMGN YSARKIRMHV HTNNKITRIY
NVIGILRGTV EPDRYIILGG HRDSWVFGGI DPTTGTAVLQ EVARSFGKLK MEGWRPRRTI
IFASWDAEEF GLLGSTEWAE ENVKVLQERA VAYINSDSSI EGNYTLRADC TPLLYQLVYN
LTKEISSPDE GYESKSLYES WLEKDRSLDD DDQPRINKLG SGSDFEAYFQ RLGIASGRVR
YTKNRKADKY SNYPVYHTVY ETFELVEKFY DPTFRKQLAV AQLRGSLVYE LADSHVIPFN
CQDYGEALRK YAKRIYNLAK KHEEQMETYE VSFEPLFSAV RNFTKAAADF HRRLEHVDLK
NPLAVRSMND QLMFVERAFI DPLGLPGRKF YRHVIFAPSS HNKYVGESFP GIYDALFDIE
NKVDLQKTWE HVKRQISIAA FTVQAAAGTL KEVA
//
