ID A0A151MX81_ALLMI Unreviewed; 1203 AA.
AC A0A151MX81;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=DHX29 {ECO:0000313|EMBL:KYO29117.1};
GN ORFNames=Y1Q_0009910 {ECO:0000313|EMBL:KYO29117.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO29117.1};
RN [1] {ECO:0000313|EMBL:KYO29117.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO29117.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO29117.1}.
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DR EMBL; AKHW03004724; KYO29117.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151MX81; -.
DR STRING; 8496.A0A151MX81; -.
DR eggNOG; KOG0920; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF145; ATP-DEPENDENT RNA HELICASE DHX29; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:KYO29117.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525}.
FT DOMAIN 417..589
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 692..861
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 23..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..80
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..296
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1203 AA; 135391 MW; 63C7B9A51E8A942B CRC64;
MGGKSKKHRG GAGAGVVHPA VSAATAAARA RAAAEGGGAA GEAAAKRQAP RPAPACREPR
VKQGPKTYSF GSSTDSSGAV SNQDKSVLKV VINSNLEKRI IGVINEHKKQ YDDKGMISRR
LTAKKLQDVY MALQGFSFKT EHIEEAMKNT ILYGGDLHSA LDWLCLNLSD DALPEGFSQQ
FEEEQHKPRA KFYSPVPQCG THQMPNNRMK EGGPEIKQKN TGKDKELSMK EWILQYAEQQ
SDDEKNESVN DLEYEEKFDP NERYLHLAAK LSEAKEQASS SKQDKDKQGQ KAAQEKIRRI
QQEMSTLEEH PVFNPDIKIA NQQQNEMKKP PLSSEAPLNL SLLEKSGAVP QEQKVKKKEP
LDVRNFDYSA RSWTGKSPKQ FLIDWCRKYF SKSPNPSFEK VPVGRYWKCR VRITKSADDI
MTACPTIVTE DSMQAQHLAA TLALYHLVKG QSVHQLLPPT YRDVWLEWTV SLATRVCEEL
GCEAGPGGKN SLCGYQIRME SRTGEATRLL YCTTGVLLRK LQEDGLLSNV SHVIVDEVHE
RSVQSDFLLI ILKEILHKRS DLHLILMSAT VDSEKFSSYF SHCPILRISG RSYPVEVFHV
EDVIEEIGYV LEKDSEYCQK FLEEEEEITI NVTKKGGEIT KYQEYIPLQS GSGVDVNSYY
QKYSSCTQQA IFYMNPYKIN LDLILELLAF LDRTPQFKNV EGAVLIFLPG LAHIQQLYDL
ISTDRRFNLR DRHRLIALHS ILSTQDQAAA FTIPPPGIRK IVLATNIAET GITIPDVVFV
IDTGRTKENR YHESSQMSSL EETFVSKASA LQRQGRAGRV RDGFCFRMYT KDRFESFMEY
SVPEILRVPL EELCLHIMKC NLGAPEDFLS RALDPPQPQV ISNAMNLLRK IGACELIEPR
LTPLGQHLAA LPVNVKIGKM LIFGAIFGCL DPVATLAAVM TEKSPFTTPI GRKDEADLAK
SSLALANSDH LTIYNAYLGW KKARQEGGYR TEMTYCRRNF LNRTSLLTLE DVKQELIKVV
RTAGFATPAT KHGWDGNGST QTLSLQEIAL LKSVLTAGLY DNVGKIMYTK SVDVTEKLSC
MVETAQGKAQ VHPSSVNRDL QTYGWLLYQE KIRYARIYLR ETTLISPFPV LLFGGDIEVQ
HRERLLSVDG WIHFQAPVKI AVIFKQLRVL IESVLKKKLE NPKMSLEDDK ILHIIKELIK
TES
//
