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Database: UniProt
Entry: A0A151N2S5_ALLMI
LinkDB: A0A151N2S5_ALLMI
Original site: A0A151N2S5_ALLMI 
ID   A0A151N2S5_ALLMI        Unreviewed;      1951 AA.
AC   A0A151N2S5;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   25-OCT-2017, entry version 9.
DE   RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   ORFNames=Y1Q_0016435 {ECO:0000313|EMBL:KYO31072.1};
OS   Alligator mississippiensis (American alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO31072.1};
RN   [1] {ECO:0000313|EMBL:KYO31072.1, ECO:0000313|Proteomes:UP000050525}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO31072.1};
RX   PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA   St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y.,
RA   Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A.,
RA   Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D.,
RA   Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J.,
RA   Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y.,
RA   Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E.,
RA   Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J.,
RA   Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W.,
RA   Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D.,
RA   Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.;
RT   "Sequencing three crocodilian genomes to illuminate the evolution of
RT   archosaurs and amniotes.";
RL   Genome Biol. 13:415-415(2012).
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. This channel gives
CC       rise to T-type calcium currents. T-type calcium channels belong to
CC       the "low-voltage activated (LVA)" group and are strongly blocked
CC       by nickel and mibefradil. A particularity of this type of channels
CC       is an opening at quite negative potentials, and a voltage-
CC       dependent inactivation. T-type channels serve pacemaking functions
CC       in both central neurons and cardiac nodal cells and support
CC       calcium signaling in secretory cells and vascular smooth muscle.
CC       They may also be involved in the modulation of firing patterns of
CC       neurons which is important for information processing as well as
CC       in cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KYO31072.1}.
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DR   EMBL; AKHW03004113; KYO31072.1; -; Genomic_DNA.
DR   Proteomes; UP000050525; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0008332; F:low voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0070509; P:calcium ion import; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR030154; VDCC_T_a1G.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF137; PTHR10037:SF137; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000050525};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20   1951       Voltage-dependent T-type calcium channel
FT                                subunit alpha. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5007585670.
FT   TRANSMEM     36     55       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    127    150       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    252    273       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    279    304       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    655    673       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    685    706       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    776    795       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    852    875       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1170   1188       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1208   1229       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1305   1327       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1406   1430       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1493   1512       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1524   1545       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1627   1647       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1711   1732       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        1    315       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      654    881       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1168   1440       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1493   1743       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1436   1473       {ECO:0000256|SAM:Coils}.
FT   COILED     1732   1756       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1951 AA;  220377 MW;  46CF61492F53B133 CRC64;
     MLVILLNCVT LGMFHPCEDT ACGSPRCRIL QSFDDFIFAF FAVEMIVKMI ALGIFGKKCY
     LGDTWNRLDF FIVIAGMLEY SLDLQNVSFS AVRTVRVLRP LRAINRVPSM RILVTLLLDT
     LPMLGNVLLL CFFVFFIFGI VGVQLWAGLL RNRCFLPENF SIPYTVELER YYQTENEDEN
     PFICSQPREN GMRYCRNIPT RREEGLECTL DYYSYNDTTN TSCVNWNQYY TNCSAGEHNP
     FKGAINFDNI GYAWIAIFQV ITLEGWVDIM YFVMDAHSFY NFIYFILLII VGSFFMINLC
     LVVIATQFSE TKQRESQLMK EQRVRYLSNA STLASFSEPG SCYDELLKYL VYVTRKASKQ
     LVEAYRAAGL KMGLLSSPGN KNGADRQPCK HRQRKRSSVH HLIHHHHHHH HHYHMGNGNL
     QAPRASPEIS DVETSSLPNS TNRLMLPPST PNLHGASSNT ESVHSIYHAD CHFEPIRCRS
     SLPQPGLSLP SPEGVPKSMV GWKVYPTVHP STSHEMLKEK SLGELAANPG AGTLTNLNIP
     PGPYSTMHKL LENQSTGACQ SSCKITSQCG KLDSGSCNPD SCPYCIKTLA NDPELVDNEA
     ADSDSEGVYE FTQDAHYSDR RDPQRGEIRG KKMSRFLVFW NIVCETFRKI VDSKYFGRGI
     MIAILINTLS MGIEYHEQPE ELTNALEISN IVFTSLFALE MLLKVLVYGP FGYIKNPYNI
     FDGIIVVISV WEIVGQQGGG LSVLRTFRLM RVLKLVRFMP ALQRQLVVLM KTMDNVATFC
     MLLMLFIFIF SILGMHLFGC KFASERDGDT LPDRKNFDSL LWAIVTVFQI LTQEDWNKVL
     YNGMASTSSW AALYFIALMT FGNYVLFNLL VAILVEGFQT EGDASKSDSE GDVFPPSLEE
     EGGLKKHLSN PALMALSDHP DLKKSLTPPL IIHTAATPMP MPKSAMFGDA AQGYESRRAS
     SVSMDPSAHE FKSPSSIRSS PHSPWSAASS WNSRRSSWNS IGRAPSLKRR GQSGERKSLL
     SGDGKESSED GESSDEEQSS RAGSINGSLP HRMESLEAKG SFDLQDTLQV PSLYRTSSMY
     SSRTSASEHQ DCNGKTSAGA LLHQFHLDDP RQDCDDCDDE GNMSKRDRAK AWIQARLPTW
     CKERDSWSIY IFAPHSKFRL MCNKIITHKM FDHVVLVIIF LNCITIAMER PKIEPHSAER
     IFLTLSNYIF TVIFLAEMTV KVVALGLCFG EKAYLKSSWN VLDGVLVLIS VIDILVSMVS
     DSGTKILGML RVLRLLRTLR PLRVISRAQG LKLVVETLMS SLKPIGNIVV ICCAFFIIFG
     ILGVQLFKGK FFVCQGEDTR NITNKSDCAE ASYKWVRHKY NFDNLGQALM SLFVLASKDG
     WVDIMYDGLD AVGVDQQPVM NYNPWMLLYF ISFLLIVAFF VLNMFVGVVV ENFHKCRQHQ
     EEEEAKRREE KRLRRLEKKR RSKEKQMAEA QCKPYYSDYS RFRLLIHQMC TSHYLDLFIT
     GVIGLNVITM AMEHYQQPKV LDEALKICNY IFTVIFVLES VFKLIAFGFR RFFQDRWNQL
     DLAIVLLSIM GITLEEIEVN ASLPINPTII RIMRVLRIAR VLKLLKMAVG MRALLDTVMQ
     ALPQVGNLGL LFMLLFFIFA ALGVELFGDL ECNDTHPCEG LGRHATFRNF GMAFLTLFRV
     STGDNWNGIM KDTLRDCDQE STCYNTVISP IYFVSFVLTA QFVLVNVVIA VLMKHLEESN
     KEAKEEAELE AELEMEMKTI APGQHPSSDL FAWTGGNGGD RPESPKGSTN PMQIKVDSQL
     SLFYPMTNFH SKNDTLTLSP SKDLLSVRKP SVGRTHSLPN DSYMFQPPYS GPCAGTPGER
     KPSYLKSQSG SKTSVQSQPA DTSSLLQIPK VHFHRIRPHD NLDGEGRPKT PRPAHSPSAE
     RLLRRQMAIR NDSLDTHCSE SKENLQVEHK M
//
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