ID A0A151N5D3_ALLMI Unreviewed; 690 AA.
AC A0A151N5D3;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=SH2B adapter protein 2 isoform B {ECO:0000313|EMBL:KYO32008.1};
GN Name=SH2B2 {ECO:0000313|EMBL:KYO32008.1};
GN ORFNames=Y1Q_0007039 {ECO:0000313|EMBL:KYO32008.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO32008.1};
RN [1] {ECO:0000313|EMBL:KYO32008.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO32008.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SIMILARITY: Belongs to the SH2B adapter family.
CC {ECO:0000256|ARBA:ARBA00010220}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO32008.1}.
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DR EMBL; AKHW03004004; KYO32008.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151N5D3; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0035591; F:signaling adaptor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01231; PH_SH2B_family; 1.
DR CDD; cd10411; SH2_SH2B2; 1.
DR Gene3D; 6.10.140.110; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR015012; Phe_ZIP.
DR InterPro; IPR036290; Phe_ZIP_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR030523; SH2B.
DR InterPro; IPR035058; SH2B2_SH2.
DR PANTHER; PTHR10872; SH2B ADAPTER PROTEIN; 1.
DR PANTHER; PTHR10872:SF4; SH2B ADAPTER PROTEIN 2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF08916; Phe_ZIP; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00233; PH; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF109805; Phenylalanine zipper; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 252..365
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 479..577
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 123..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 198..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 620..690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..232
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 623..662
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..679
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 690 AA; 76891 MW; A2B47964AB76614A CRC64;
MLESPGSRLC TRVVSGSRVN KTHKELSHVT MSHEGCSESL LAAAVDFAQK FCQFLKENPH
YDTPGAETSF SHHFAANFLD IFSLEVSRVF VSDSPTKYNI VPFVGLQNCH MPYGRDIIQR
KEETSTESLD SMDNPVSSSR YLSQSQQAQA HKVSSYGHSR SSEDVSVHAT SKPKFKKGFS
LRNMSLCVVD GMKEMWHRKS SPEPGIEATQ SSRRSDKEHC PSGNKEHNDT RERWTHKLRL
SKVQSSKVEL VDIQREGTLR YMVADDTNCV GSSQWQKCRL MLRKAVKMEG ERFLLEFYVP
PKASKPKVSI PLSAIIEVRT TMPLEMPDKD NTFVLKVENG AEYILETIDS LQKHSWVADI
QDCIDPGDSG DDIELASCAQ GACLPGRMSS CSCEFLSDDM HRPPDRCTMP PLHNAAPPAA
TATIISGPHS RVRDSSGEHL THVPLENFLQ TLESPATSSH LTGDESETEV EINLSDFPWF
HGTLSRIKAA QLVLFGGARS HGLFVIRQSE TRPGEYVLTF NFQGKAKHLR LSLNENGQCH
VQHLWFQTIF DMLRHFHTHP IPLESGGSAD ITLRSYVVAQ SPLPETGPSQ AIASQQPSCR
HDLPSQHYFS SFVPGAFQPA SPSEGAIASS SSSSSSHPSY HRMEGTLNTR SRSNSVERLL
ESPSVSTEDY HESDGSRNRT RAVENQYSFY
//
