ID A0A151N841_ALLMI Unreviewed; 1270 AA.
AC A0A151N841;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Adhesion G-protein coupled receptor G4 {ECO:0000313|EMBL:KYO32769.1};
GN Name=GPR112 {ECO:0000313|EMBL:KYO32769.1};
GN ORFNames=Y1Q_0009365 {ECO:0000313|EMBL:KYO32769.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO32769.1};
RN [1] {ECO:0000313|EMBL:KYO32769.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO32769.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01172}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO32769.1}.
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DR EMBL; AKHW03003879; KYO32769.1; -; Genomic_DNA.
DR RefSeq; XP_019348335.1; XM_019492790.1.
DR RefSeq; XP_019348336.1; XM_019492791.1.
DR RefSeq; XP_019348337.1; XM_019492792.1.
DR RefSeq; XP_019348338.1; XM_019492793.1.
DR AlphaFoldDB; A0A151N841; -.
DR STRING; 8496.A0A151N841; -.
DR GeneID; 109284429; -.
DR KEGG; amj:109284429; -.
DR CTD; 139378; -.
DR OrthoDB; 5405434at2759; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15997; 7tmB2_GPR112; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR001759; Pentraxin-related.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF277; ADHESION G-PROTEIN COUPLED RECEPTOR G4; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00354; Pentaxin; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00159; PTX; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51828; PTX_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:KYO32769.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 894..920
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 932..951
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 957..981
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1001..1023
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1050..1081
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1102..1122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1128..1149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 895..1151
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 340..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1270 AA; 142344 MW; 900A31B26B29B533 CRC64;
MKRHMQARGQ GFPDKLLCGL VVTASLFLLS ETSSLRGKKL DLSAKYQKYV SLANTSIPQL
CQFTVCIDLN RTTNVSIWTA FSYDINNNST NIHDAELGLS GENKHLKLYL FGTTREIKLD
LTLFEWHSVC YTWDSKEGLL QVYNNGQHLE TEAMNSTKCL RPKGSLVLGY LHKNQGGSII
VQVNSGFIGN LYYFQMWDRV LKQEELMNCS QGNVVSWNAG HWDFDNIIPV TDHHLRCAKS
WEGSASTTAA TLAPPSPAKT TSGITLTFTA SMGGVTTENK ATCAPKYTTK KTSSASLTTA
VTQAPETIPA TKPRGTTQAF VSLLTTTTKV TVLVSETTLS LTTASPRPDE TDPTSKPDGI
QTSVTASPIK TTSTMSVSRS MVTSKPSEFT FVSTPDLTTA GHKLVTFYNI QVNFSATHEP
QRPPDYYDVR NLTETWLNDR LSGTEFLVTN YKIKTVGRAS TGGRVQRKAQ MEKKQNSRSY
GSKAIVKAES SETQEVLTEK ITQLLTGTYV ETPTSFSLEL DNVTVAPIDP GNCPGNPTHS
EYKGTYLWPL TTAFGKTELN CTKNPQQLAK RHCVINIERG KARWKRPDLS VCKLLKELPN
NILDLQYIII TEENAQDVAE HILNLIVNLT QLEAEEMKII VDTTSDIANC SEISMTLAKT
TLGILNMVLL KQNNTHSLHK VTNRVLRTIE QIGYRMTYPG RNASIIMAAL ALVVTHPDPS
SFQGLAFGVT SYKEDLNPKI EMQETPFQKA LASVFLPRLM REYLGIHSFD PEDHPKIQFT
FFGTTSLFMG GSSGNETLNT YVVSASIENV SIQNLKEPVN IILEHINPNM DNASVRCVFW
DFMKNNGLGG WNTSGCEMQY TDMNYTICYC NHLTHFGVLM DLSRTPTDPV NDRILTLITH
AGCGVSSLFL GVVLVIYLAL DKLRRDYPSK ILINLCAALL MLNLIFLVNS WLTSFNNHGL
CITVAVFLHY FLLTAFTWMG LESVHMYLAL IRVFNTYIPH YILKFCIAGW GLPAVVVAII
LIIKKDFYGS RSPSESNNPF TDFCWIENNV VFYISVAAYF CFIFLINMVV FIAVLVQIHF
MKSKTRTRSK DWKKRFLHDL KSTISLTALL GLTWGFAFFA WGPVKICFQY LFAICNTLQG
VFIFVYHCLM KENVRKQCRV HFCWGRFRLN NYSDWSGSGS GYKPRNVEDN LFFHSLKSTK
SMKSNGTSST SNGSSCLQGT SLDMNFRIGE VHYNPGALMP PDHEARCPWT RRVSPMDVQL
HCTQKSRFLQ
//
