ID A0A151NB11_ALLMI Unreviewed; 991 AA.
AC A0A151NB11;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=DHX36 {ECO:0000313|EMBL:KYO33990.1};
GN ORFNames=Y1Q_0024589 {ECO:0000313|EMBL:KYO33990.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO33990.1};
RN [1] {ECO:0000313|EMBL:KYO33990.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO33990.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO33990.1}.
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DR EMBL; AKHW03003627; KYO33990.1; -; Genomic_DNA.
DR RefSeq; XP_006263941.1; XM_006263879.3.
DR AlphaFoldDB; A0A151NB11; -.
DR STRING; 8496.A0A151NB11; -.
DR GeneID; 102573095; -.
DR KEGG; amj:102573095; -.
DR CTD; 170506; -.
DR eggNOG; KOG0920; Eukaryota.
DR OrthoDB; 1095660at2759; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17981; DEXHc_DHX36; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934:SF237; ATP-DEPENDENT DNA_RNA HELICASE DHX36; 1.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:KYO33990.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 200..370
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 459..630
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..77
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 991 AA; 112900 MW; D894FD812FE682C4 CRC64;
MSYEHRRGWG RGRGGSGGGG GGGSSRPSSS EAGYGGRGGG GGGGRGRHPG HLKGREIGLW
YARKHGQRSK EADRQQRAVV QMDEHREEQI VQLLNTVQTR NEKEQEAMSW WSGEEEGPDQ
VEQVKEKPTL EKVPIKHRPN LERTFLDRDA EFLFQKNEPD IDLDEQFREE LRKKKSDSRY
IEMQRFREKL PSYGMRRELV NVINNNQVTV ISGETGCGKT TQVTQFILDD YIERGKGSAC
RIVCTQPRRI SAISVAERVA TERAEVCGNG KSTGYQIRLQ SRLPRKQGSI LYCTTGIILQ
WLQSDKQLSS VSHVVLDEIH ERNLQSDVLM TVIKDLLNVR SDLKVILMSA TLNAEKFSEY
FDNCPMLHIP GFTFPVVEYL LEDVIEKLRY MPENTDRRPR WKKGFMQGHI SRPEKEEKEE
IYRERWPDYL KQLQGRYSTS TIAALESMDD DKIDLDLIAV LIRYIALEEE DGAILVFLPG
WDNISTLHDL LMSQVMFKSD RFVIIPLHSL MPTVNQTQVF KKTPPGVRKI VIATNIAETS
ITIDDVVFVI DGGKIKETHF DTQNNISTLA AEWVSDANAK QRKGRAGRVQ PGHCFHLYNG
LRASLLDDYQ LPEILRTPLE ELCLQIKILK LGGIAHFLSK LMDPPSHDAV MLSINHLMEL
NALDRQEELT PLGVHLARLP VEPHIGKMIL FGALFCCLDP VLTIAASLSF KDPFVIPLGK
EKVADARRKE LSKNTKSDHL TIVNAFTGWE EARRRGFRNE KDYCWEYFLS SNTLQMLHNM
KGQFAEHLLA AGFVNSKDPK DPKSNTNSDN EKLLKAVICA GLYPKVAKIR PSFSKKRKMV
KVCTKPDGTV NIHPKSVNVE ETEFHYNWLV YHLKMRTSSI YLYDCTEVSP YCLLFFGGDI
SIQKDNDQDT IAVDEWIVFQ SPARIAQLVK NLRSELDDLL QEKIENPHPV DWNDTKSRDT
AVLTAIIDLI TTQENESARN FAPRFQNERY S
//
