ID A0A151NB56_ALLMI Unreviewed; 1581 AA.
AC A0A151NB56;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Multiple epidermal growth factor-like domains protein 6 isoform A {ECO:0000313|EMBL:KYO34068.1};
GN Name=MEGF6 {ECO:0000313|EMBL:KYO34068.1};
GN ORFNames=Y1Q_0024653 {ECO:0000313|EMBL:KYO34068.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO34068.1};
RN [1] {ECO:0000313|EMBL:KYO34068.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO34068.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO34068.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AKHW03003627; KYO34068.1; -; Genomic_DNA.
DR eggNOG; KOG1218; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 7.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR011489; EMI_domain.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR042635; MEGF10/SREC1/2-like.
DR PANTHER; PTHR24043:SF8; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24043; SCAVENGER RECEPTOR CLASS F; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF14670; FXa_inhibition; 4.
DR Pfam; PF00053; Laminin_EGF; 8.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 33.
DR SMART; SM00179; EGF_CA; 8.
DR SMART; SM00180; EGF_Lam; 22.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS00022; EGF_1; 20.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 11.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS51041; EMI; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1581
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007585900"
FT DOMAIN 26..107
FT /note="EMI"
FT /evidence="ECO:0000259|PROSITE:PS51041"
FT DOMAIN 106..141
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 308..348
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 540..576
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 584..619
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 806..837
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 932..967
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1018..1053
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1104..1139
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1277..1312
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1362..1397
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1453..1483
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 131..140
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 566..575
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 609..618
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 827..836
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 957..966
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1043..1052
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1129..1138
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1302..1311
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1387..1396
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1473..1482
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1581 AA; 170003 MW; 6E68B85E1258E5F6 CRC64;
MSPRAWLLCA SCTLAAWASA ALQPGMPNVC PEQELAMVGY QQPCVQAFTR MIKMWKQGCT
GQRWCVSHER RTGYYTVYKQ MYRMEHQTVY KCCPGWMQQD DEPGCSRSLC TVGTCFNGGK
CSEEGSQMCQ CPEGFQGPRC QYDVNECTIE NGGCYDQCCN TIGSYYCKCP AGQKLGKDGK
SCEDVDECVI VNGGCQQSCV NIQGSFFCEC TMGYRLHADG RTCITVNSCT VNNGGCEQEC
IQITEDHYRC QCQPGYQLQR NGKHCEMIDP CAAGNGGCPH ICQNERGFAK CECHPGHYLS
ADKRSCLDID ECVEGTARCA HRCVNTLGSF TCVCNPGFEL GADGKQCYRI EMEIVNSCES
NNGGCSHRCE HSTGGPHCSC NQGYVLDLDG KTCIELDECE TGEACCSQFC INYLGGYECT
CKAGFQLNID GCGCDDEDEC VVDNGDCDQV CVNSLGSYEC ACEEGYVLGI NGQTCITLDN
DELNKEEEEE LEISRIPDLQ FRRPPQLLKY AVTLDPFYED EDVRGELTLM QKVVCLDSTF
GNDCSLSCED CMNGGTCNSE NSGCICLPGW TGMICNETCS PGTYGKNCNS ICKCQNGGSC
DPVTGQCHCP LGISGKICED GCPKGFFGKN CNKKCNCANN GYCHRLYGAC LCDPGLYGRF
CHLTCPKWVF GAGCSEECQC VKENTLECNA RNGTCTCKPG YQGSRCQKEC MPGFYGAGCK
LKCNCSDVLC DHKTGECKHP CPPGFHGEKC HLSCNPGKFG VNCRQSCSCG GASCDPETGR
CLCPAGKTGS ACGQDCPEGL WGVGCQFFCE SCENGGQCNR ETGICDCPLG YTGKSCSAPC
PYGYYGQNCL LQCSCNINAQ CHHVTGECTC PPGWTGYDCK RSCDTGHWGQ HCENACVCSN
SDGSCDPVTG VCFCESGYTG KHCEQSCPNG TFGPGCKYSC QCKNGAVCDH VSGACTCAAG
WTGTFCEKAC PDGFFGLDCH QVCECKNAAS CNHIIGTCHC LPGWVGAKCD QSCQGDSFGE
NCSHVCNCHN GALCDHVTGT CICRAGWRGA TCQEACPPGL YGVNCVQYCI CHNRATCDRV
SGACICPRGW TGIVCELECQ EGKYGERCEQ NCNCSNGGVC DRYSGKCSCQ PGWIGGQCDV
VCPSGFFGEQ CKERCDCKHS LSCHHQTGVC HCHKGWRGKQ CDKPCLSGYY GINCAQRCNC
ALGTPCHHVT GECGCPQGFT GYGCEKTCSP GTYGKNCNQV CQCSAENEEC HPVTGKCTCL
PGYYGIHCDL RCPKGTYGPY CQKACKCLNG GLCDPMTGTC DCPPGFIGAN CSKSCPENRH
GKDCSLWCSC GKGQCDPVTG KCYCPPGYIG PDCQQVCPQG RYGPNCQRMC ICKNGGICSH
VDGSCTCGLG WTGSYCEREC PPGRYGSDCH LHCSCQNNGT CDRFTGCCQC PEGYYGHACE
HTCPSGFFGL NCLHSCDCKN GASCNIVTGQ CICPAGYQGI QCEKGCKPGW FGDRCQYQCE
CGGVALCDPV TGKCLCPPGR TGDRCGSECK SGQYGPNCSL QCQCANKSQC NPQNGKCRCP
SKWMGPTCEE GDPTKLPSYE G
//
