ID A0A151NDJ1_ALLMI Unreviewed; 918 AA.
AC A0A151NDJ1;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Interleukin-1 receptor-associated kinase 1 {ECO:0000313|EMBL:KYO34868.1};
GN Name=IRAK1 {ECO:0000313|EMBL:KYO34868.1};
GN ORFNames=Y1Q_0017056 {ECO:0000313|EMBL:KYO34868.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO34868.1};
RN [1] {ECO:0000313|EMBL:KYO34868.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO34868.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO34868.1}.
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DR EMBL; AKHW03003281; KYO34868.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151NDJ1; -.
DR STRING; 8496.A0A151NDJ1; -.
DR eggNOG; KOG1187; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0070887; P:cellular response to chemical stimulus; IEA:UniProt.
DR GO; GO:0045087; P:innate immune response; IEA:UniProt.
DR GO; GO:0043170; P:macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0006807; P:nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR GO; GO:0048583; P:regulation of response to stimulus; IEA:UniProt.
DR GO; GO:0010033; P:response to organic substance; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01396; MeCP2_MBD; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR27001; OS01G0253100 PROTEIN; 1.
DR PANTHER; PTHR27001:SF489; PROLINE-RICH RECEPTOR-LIKE PROTEIN KINASE PERK8; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00391; MBD; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KYO34868.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Receptor {ECO:0000313|EMBL:KYO34868.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 93..165
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 583..874
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 150..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 526..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 886..918
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..272
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..390
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 893..918
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 610
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 918 AA; 98312 MW; C439F09E46C257EB CRC64;
MHVSRSGCSH GRHGKGEEKV EDQHTQGKPG KAKKTKKERQ QHETVAAAGG QPSAEPAEAG
KAETSEGEGG AGAAPAAPEP SASPKQRRSI IRDRGPMYDD PTLPEGWTRK LKQRKSGRSA
GKYDVYLINP QGKAFRSKVE LIAYFEKVGD TSLDPNDFDF TVTGRGSPSR REHKPPKKPK
APKGPGTGRG RGRPKGSGAA AKARAGPVEG VQVKRVVEKS PGKLLVKMPF QPGPAGAKEG
GGVATASAPV LALRRPGRKR KAEPDLQATP KKRGRKPGGG AGVGTPVAAA EVRKKAAKEA
VVSATAPAAA HETLLPIKKR KTREAVALEP RPLPPAPERG GPKGPKAGRR SKEGSPKGRG
GAGGSLPAKK EPPLPPLLQP PHPEPPASPP DSVFCRLMDA LGRADWERFA SRVVRDQVEL
RLAGTSEGRT QRVLWSWGHR NARVGDLLAL LGELELDWAH DLIASWQPPP EPWTRLPHST
SLAPPLPSVP LPSVPPAPCS TARTLPWDPP KALPVPVPPL PEPSCLSLPL PGPPPRSLLS
TSSHDTVTSP DPVTLLSQVL PPPGFPRLLA WPLAELVEAT GGFSEQHKVG EGGFGCVYRA
RLRHTDCAVK RLKEDAELNW NLVHNSFITE LEKLSRYRHP NIVELAGFCA EKGHFCLVYV
FMPNGSLDDR LRPQDGRPPL TWPQRLSVLV GAARAIQFLH QDVPSLIHGD VKSSNILLDQ
ALTPRLSDFG LARVGVGGGR GGRSGTLGRT GTVRGTLAYL PPEYVQTGAL SPAIDTYSFG
VVLLEALTGR RALETDERGQ TKYLKDLVAA EEEESGVGDR DVGTRLGQAY ADSQAGPCPP
LLSTSLGHLA AQCLHRRSKQ RPHMDQVYEE LERLQQALCW EPALPPCRSP VDPQNQPEES
DDSLPGVGDS FSSESCWV
//