ID A0A151NG92_ALLMI Unreviewed; 2176 AA.
AC A0A151NG92;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Protein unc-13 homolog B {ECO:0008006|Google:ProtNLM};
GN ORFNames=Y1Q_0024442 {ECO:0000313|EMBL:KYO35831.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO35831.1};
RN [1] {ECO:0000313|EMBL:KYO35831.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO35831.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO35831.1}.
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DR EMBL; AKHW03003090; KYO35831.1; -; Genomic_DNA.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0098793; C:presynapse; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019992; F:diacylglycerol binding; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR CDD; cd20859; C1_Munc13-2-like; 1.
DR CDD; cd08394; C2A_Munc13; 1.
DR CDD; cd04027; C2B_Munc13; 1.
DR CDD; cd08395; C2C_Munc13; 1.
DR Gene3D; 1.10.357.50; -; 1.
DR Gene3D; 1.20.58.1100; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 3.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR010439; MUN_dom.
DR InterPro; IPR014770; Munc13_1.
DR InterPro; IPR014772; Munc13_dom-2.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR027080; Unc-13.
DR InterPro; IPR037302; Unc-13_C2B.
DR PANTHER; PTHR10480; PROTEIN UNC-13 HOMOLOG; 1.
DR PANTHER; PTHR10480:SF8; PROTEIN UNC-13 HOMOLOG B; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00168; C2; 3.
DR Pfam; PF06292; MUN; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00239; C2; 3.
DR SMART; SM01145; DUF1041; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 3.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR PROSITE; PS50004; C2; 3.
DR PROSITE; PS51258; MHD1; 1.
DR PROSITE; PS51259; MHD2; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 1..110
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1077..1127
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 1183..1307
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1617..1760
FT /note="MHD1"
FT /evidence="ECO:0000259|PROSITE:PS51258"
FT DOMAIN 1867..1990
FT /note="MHD2"
FT /evidence="ECO:0000259|PROSITE:PS51259"
FT DOMAIN 2004..2131
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 183..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 610..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 852..953
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 627..644
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 852..871
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 876..891
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 907..942
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2176 AA; 247202 MW; 21519817D7093E8E CRC64;
MEVEVGLGWS FPECCRLSAA VKKAKLHGPP DKFNTYVTLK VQNVKSTTVA VRGDQPCWEQ
DFMFEINRLD LGLIVEVWNK GLIWDTMVGT RWIPLKTIQQ SDEEGPGEWS TLEAEVVMKH
DEICGTRKPT LHKILLDARF ELPFDIPEEE ARYWTKKLEQ INSMGDHDEY CFTEEVQKKP
LPSAASQCSF EDPDSAVDDR DSDYRSETSN TLPPPYHTTS QPNASVHQFT VPSRLQQQGV
LRDFCHDSVQ SYDLDYRECE AIRRYDSLDS TVSGRTDLES SSESSQVTSR QHSLGSRQSL
DLSDSQGSLV RNEKVRIIPF NSEVAEEERE SNYEELGKLL IEDFLEKSHK NWQETNNVFL
EPGILDIPRY PQEYDTIDRR RKKNLKYSTL EKSEQISLHN DGSAKYNGSS ESTELLPGYP
ILRPYKNGLL VKSGKCVSKQ VADGDCAGPA HLGRCEEARR PEQPDNTFVP LDVLEELDSS
ASDEFQYSSV SDDEAEDLAV LSQTWGGCGK NHKTKGGKHS YSMQDLTLSP VEEPSEEYVD
AMDELQCLVE TAKPLCTEDS KESSKNKSES LPDLTSVKNT VNSLFSSFTE KDKTKSNMLG
LMKFFDRNED SSLEKKSSSS DATSGAQKKP DDVKATDSSK TKKVQDLSGK TIIGRNDPYH
DTRSKMYQTP FSERAIEFLN YSLLNGDAQN ILEQLPTCEE TRSRSGFEWE YDVEGFSVDV
WHWPESSDTV MNLCKKDGNA NLMFQEVYSE ENDVWAASSL NGNYSQLPAF QMDCSYSEEL
PMDLSCSSGG DGNMWTLIDQ ESLSVEDNFV YSSYSQEYQN WLTLLERGVW WPSEDGDCGY
YMYSDGHPAG SSRYGSSCSV SQGSSHLSEP DPCQESAHGS EQEEEPREPE SNPSYRSPGT
YQKDGQEWHN GQEEPKQFDS QAEKEKVCEK EEKVKDPSTP KLPPELEKPQ AASAGLAERY
LDENEAPLFP PARAYWIRAI NKVRVQLQEV QDDGDPSKQP WLKGGPAGGL YGIDSMPDLR
KKKPVPLVSD LSLVQSRKAG ITSAMATRSS LKDEELKSHV YKKTLQALIY PISCTTPHNF
EVWTATTPTY CYECEGLLWG IARQGMRCTE CGVKCHEKCQ DLLNADCLQR AAEKSSKHGA
EDRTQNIIMA MKDRMKIRER NKPEIFDLIR DVFCESKLAH AQQMKTVKQS VLDGTSKWLA
KITITVVCAQ GLQAKDKTGS SDPYVTVQVG KTKRRTKTIY GNLNPVWEEK FHFECHNSSD
RIKVRVWDED DDIKSRVKQR LKRESDDFLG QTIIEVRTLS GEMDVWYNLE KRTDKSAVSG
AIRLQISVEI KGEEKVAPYH VQYTCLHENL FHHLTDIQGN GVVKIPDAKG DDAWKVYFDE
TAQEIVDEFA MRYGIESIYQ AMTHFACLSS KYMCPGVPAV MSTLLANINA YYAHTTASTN
VSASDRFSAS NFGKERFVKL LDQLHNSLRI DLSTYRNNFP ASSPERLQDL KSTVDLLTSI
TFFRMKVQEL QSPPRASQVV KDCVKACLNS TYEYIFNNCH ELYSREYQLD PNKNQDLPPE
EQGPSIRNLD FWPKLITLIV SIIEEDKNSY TPVLNQFPQE LAVGKISAEV MWNLFAQDMK
YAMEEHEKNR LCKSADYMNL HFKVKWLYNE YVRDLPAFKG KVPEYPAWFE QFVMQWLDEN
EEVSFEFLHG ALERDKKDGF QQTSEHALFS CSVVDVFTQL NQSFEIIKKL ECPDPVIVAH
YMRRFAKTIG KVLMQYADIL SRSFRSYCSK EKLPCILMNN IQQLRVQLEK MFEAMGGKEL
DPEASDHLKE LQVRLNNVLD ELSAVFGNSF QTRIDECVKQ MSDILCQVKG TGNIPANARN
TVAQDADNVL RPLMDFLDGN LTLFATVCEK TVLKRVLKEL WRVVMNTMEK LIVLPPLTDH
TDHMVREETR SLTPKQCVVL DLALDTIKQY FHAGGNGLKK TFLEKSPDLQ SLRYALSLYT
QTTDTLIKTF VQTQTAQGSG VDDPVGEVSI QIDLYTHPGT GEHKVTVKVV AANDLKWQTS
GMFRPFVEVT MIGPHQSDKK RKFTTKSKSN NWAPKYNETF HFILGNEDGP DAYELQVCVK
DYCFAREDRV LGIAVMQLRD IADKGSCACW CPLGRRIHMD ETGLTVLRIL SQRTNDEVAR
EFVKLKSESR STEEGT
//
