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Database: UniProt
Entry: A0A151NI03_ALLMI
LinkDB: A0A151NI03_ALLMI
Original site: A0A151NI03_ALLMI 
ID   A0A151NI03_ALLMI        Unreviewed;      1713 AA.
AC   A0A151NI03;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   25-OCT-2017, entry version 10.
DE   RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   ORFNames=Y1Q_0024060 {ECO:0000313|EMBL:KYO36289.1};
OS   Alligator mississippiensis (American alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO36289.1};
RN   [1] {ECO:0000313|EMBL:KYO36289.1, ECO:0000313|Proteomes:UP000050525}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO36289.1};
RX   PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA   St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y.,
RA   Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A.,
RA   Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D.,
RA   Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J.,
RA   Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y.,
RA   Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E.,
RA   Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J.,
RA   Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W.,
RA   Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D.,
RA   Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.;
RT   "Sequencing three crocodilian genomes to illuminate the evolution of
RT   archosaurs and amniotes.";
RL   Genome Biol. 13:415-415(2012).
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. This channel gives
CC       rise to T-type calcium currents. T-type calcium channels belong to
CC       the "low-voltage activated (LVA)" group and are strongly blocked
CC       by nickel and mibefradil. A particularity of this type of channels
CC       is an opening at quite negative potentials, and a voltage-
CC       dependent inactivation. T-type channels serve pacemaking functions
CC       in both central neurons and cardiac nodal cells and support
CC       calcium signaling in secretory cells and vascular smooth muscle.
CC       They may also be involved in the modulation of firing patterns of
CC       neurons which is important for information processing as well as
CC       in cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KYO36289.1}.
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DR   EMBL; AKHW03002956; KYO36289.1; -; Genomic_DNA.
DR   Proteomes; UP000050525; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0008332; F:low voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0070509; P:calcium ion import; IEA:InterPro.
DR   GO; GO:0030317; P:flagellated sperm motility; IEA:InterPro.
DR   GO; GO:0019228; P:neuronal action potential; IEA:InterPro.
DR   InterPro; IPR030162; CACNA1I.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF209; PTHR10037:SF209; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000050525};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     24     43       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    111    135       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    248    269       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    275    300       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    500    518       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    538    556       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    621    643       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    699    721       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1011   1029       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1049   1071       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1086   1114       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1149   1168       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1248   1271       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1327   1344       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1364   1383       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1447   1474       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1549   1570       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        4    311       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      499    726       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1009   1281       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1327   1580       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1280   1307       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1713 AA;  194871 MW;  A901EAB19C3C8321 CRC64;
     MYQPCEDMDC LSDRCKILQV FDDFIFIFFA MEMVLKMVAL GIFGKKCYLG DTWNRLDFFI
     VMAGMVEYSL DLQNINLSAI RTVRVLRPLK AINRVPSMRI LVNLLLDTLP MLGNVLLLCF
     FVFFIFGIIG VQLWAGLLRN RCFMEENFTI QGDIVLPPYY QPEEDDEMPF ICSLSGDNGI
     MGCHEIPPLK ERGHECCLDK DDYYYYNSVR QEFNVSGMCV NWNQYYNVCR TGNTNPHKGA
     INFDNIGYAW IVIFQVITLE GWVEIMYYVM DAHSFYNFIY FILLIIVGSF FMINLCLVVI
     ATQFSETKQR EHQLMQEQRA RYLSSSTVAS YMEPGDCYEE IFQYICHIVR KAKRRTLSLY
     NNLQNRRQGR MEPGNMKPDM NGKGQRCYRH CQKHNSLDYT PQALVQPIAV TLTSDPNNCP
     RCHRVQREAA RRLSVLDSAD SDQENGGAGE EEGEGSRESN GVAELEKEEE EGEEGKQMRL
     CSDMWQEVRV KLRGIVESKY FNRGIMIAIL VNTISMGIEH HEQPEELTNI LEISNVVFTS
     MFALEMILKL AAFGLFDYLR NPYNIFDSII VIISIWEIIG QSDGGLSVLR TFRLLRVLKL
     VRFMPALRRQ LVVLMKTMDN VATFCMLLML FIFIFSILGM HIFGCKFSLR TDTGDTVPDR
     KNFDSLLWAI VTVFQILTQE DWNVVLYNGM ASTSPWASLY FVALMTFGNY VLFNLLVAIL
     VEGFQAEGDA NRSYSDEDQS SSNAEELDRF QDVQDGSDPK LCAIPVTPNG HLDPSPPSSN
     QPVVSAAVTN SSRNSLQPDQ VLIAVGSRKS SVMSLGRMTY DQRSLSSSRS SHYGAWGRSG
     AWGSRRSSWN SLARGHSLKH KPPSAEHESL LSGERHRTAD GERAGMGRTP HHRRTLSLDT
     KGSCDLVELA SVPPSHRATR KVGVTSGTTE HQDCNGKMPS IAKEIFPKMN NRKERGEEEE
     EIDYTLCFRI RKMIEVYKPD WCELREDWSI YLFSPQNRFR ILCQTIIAHK LFDYIVLAFI
     FLNCITIALE RPQIEHRSTE RIFLSVSNYI FTAIFVAEMT LKVVSLGLYF GDQAYLRSSW
     NILDGFLVFV SLIDIVVSVA SAGGAKILGV LRVLRLLRTL RPLRVISRAP GLKLVVETLI
     SSLKPIGNIV LICCAFFIIF GILGVQLFKG KFYHCLGVDI RNITNRSDCV AANYKWVHHK
     YNFDNLGQAL MSLFVLASKD GWVNIMYNGL DAVAVDQQPV TNNNPWMLLY FISFLLIVSF
     FVLNMFVGVV VENFHKCRQH QEAEEARRRE EKRLRRLEKK RRKAQRLPYY ASYCPVRLLI
     HSVCTSHYLD IFITFIICLN VVTMSLEHYN QPVSLETALK YCNYMFTTVF VLEAVLKLVA
     FGLRRFFKDR WNQLDLAIVL LSVMGITLEE IEINAALPIN PTIIRIMRVL RIARVLKLLK
     MATGMRALLD TVVQALPQVG NLGLLFMLLF FIYAALGVEL FGKLVCNDEN PCEGMSRHAT
     FENFGMAFLT LFQVSTGDNW NGIMKDTLRD CTQDDRSCLS NLQFISPLYF VSFVLTAQFV
     LINVVVAVLM KHLDDSNKEA QEDAEMDAEI ELEMAHGLCP RSLGSPSSGQ GGSGGGGGGG
     GGGRVDPEGR LCMRCYSPAQ ENLWLDSVSL IIKDSFDGEL MIIDNLSGSV FHHYSSPAMC
     EKCNHDKQEK IFQHSVVHGS CKMFSWPKWK PYP
//
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