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Database: UniProt
Entry: A0A151NIJ0_ALLMI
LinkDB: A0A151NIJ0_ALLMI
Original site: A0A151NIJ0_ALLMI 
ID   A0A151NIJ0_ALLMI        Unreviewed;      1926 AA.
AC   A0A151NIJ0;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   25-OCT-2017, entry version 10.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   ORFNames=Y1Q_0024310 {ECO:0000313|EMBL:KYO36618.1};
OS   Alligator mississippiensis (American alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO36618.1};
RN   [1] {ECO:0000313|EMBL:KYO36618.1, ECO:0000313|Proteomes:UP000050525}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO36618.1};
RX   PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA   St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y.,
RA   Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A.,
RA   Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D.,
RA   Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J.,
RA   Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y.,
RA   Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E.,
RA   Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J.,
RA   Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W.,
RA   Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D.,
RA   Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.;
RT   "Sequencing three crocodilian genomes to illuminate the evolution of
RT   archosaurs and amniotes.";
RL   Genome Biol. 13:415-415(2012).
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KYO36618.1}.
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DR   EMBL; AKHW03002956; KYO36618.1; -; Genomic_DNA.
DR   Proteomes; UP000050525; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005451; VDCC_L_a1csu.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   PRINTS; PR01635; LVDCCALPHA1C.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000050525};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM      7     28       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     40     57       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    113    135       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    195    216       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    228    250       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    371    388       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    408    426       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    497    519       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    573    599       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    747    766       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    778    800       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    820    843       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    864    897       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    989   1015       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1066   1087       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1099   1119       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1194   1212       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1288   1311       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1445   1479       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      602    628       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1926 AA;  217801 MW;  8B60EABAD97569DA CRC64;
     MAKKERVEYL FLIIFTVEAF LKVIAYGLLF HPNAYLRNGW NLLDFIIVVV GLFSAILEQA
     TKADGGNSIG GKGAGFDVKA LRAFRVLRPL RLVSGVPSLQ VVLNSIIKAM VPLLHIALLV
     LFVIIIYAII GLELFMGKMH KTCYHVHGAL ADTPAEEDPS PCAPQSAHGR QCQNGTECRA
     GWEGPKHGIT NFDNFAFAML TVFQCITMEG WTDVLYWMQD AMGYELPWVY FVSLVIFGSF
     FVLNLVLGVL SGEFSKEREK AKARGDFQKL REKQQLEEDL KGYLDWITQA EDIDPENEDE
     GMDEEKPRNM SMPTSETESV NTDNVAGADI EGENCGARLA HRISKSKFSR YWRRWNRFCR
     RKCRAAVKSN VFYWLVIFLV FLNTLTIASE HYQQSNWLTE VQDTANKVLL ALFTAEMLLK
     MYSLGLQAYF VSLFNRFDCF IVCGGILETI LVETKIMPPL GISVLRCVRL LRIFKITRYW
     NSLSNLVASL LNSVRSIASL LLLLFLFIII FSLLGMQLFG GKFNFDEMQT RRSTFDNFPQ
     SLLTVFQILT GEDWNSVMYD GIMAYGGPSF PGMLVCIYFI ILFICGNYIL LNVFLAIAVD
     NLADAESLTS AQKEEEEEKE RKKLARTASP EKKQEIEKPA VEEETKEEKI ELKSITADGE
     SPPATKINVD DYQPNENEEK NPYPTTEAPG EEDEEEPEMP VGPRPRPMSE LHLKEKAVPM
     PDASAFFIFS PSNRFRVHCH RIVNDNIFTN LILFFILLSS ISLAAEDPVR HTSFRNQILF
     YFDIVFTVIF TIEIALKMTA YGAFLHKGSF CRNYFNILDL LVVSVSLISF GIQSSAINVV
     KILRVLRVLR PLRAINRAKG LKHVVQCVFV AIRTIGNIVI VTTLLQFMFA CIGVQLFKGK
     LYSCSDSSKQ TLTECRGYFI TYKDGEVTQP MIQPRSWENS KFDFDNVLTA MMALFTVSTF
     EGWPELLYRS IDSHMEDVGP IYNHRVEISI FFIIYIIIIA FFMMNIFVGF VIVTFQEQGE
     QEYKNCELDK NQRQCVEYAL KARPLRRYIP KNQYQYKVWY VVNSTYFEYL MFVLILLNTI
     CLAMQHYGQS CMFKEAMNIL NMLFTGLFTV EMVLKLIAFK PKHYFCDAWN TFDALIVVGS
     IVDIAITEVN NAEENSRISI TFFRLFRVMR LVKLLSRGEG IRTLLWTFIK SFQALPYVAL
     LIVMLFFIYA VIGMQVFGKI ALNDTTGINR NNNFQTFPQA VLLLFRCATG EAWQEIMLAC
     LSGKKCDPES EPANSTEGDH SCGSSFAIFY FISFYMLCAF LIINLFVAVI MDNFDYLTRD
     WSILGPHHLD EFKRIWAEYD PEAKGRIKHL DVVTLLRRIQ PPLGFGKLCP HRVACKRLVS
     MNMPLNSDGT VMFNATLFAL VRTALRIKTE GNLEQANEEL RAIIKKIWKR TSMKLLDQVV
     PPAGDDEVTV GKFYATFLIQ EYFRKFKKRK EQGLVGKPSQ RNALSLQAGL RTLHDIGPEI
     RRAISGDLTA EEELDKAMKE AVSAASEDDI FRRAGGLFGN HVSYYQSDGR STFPQTFTTQ
     RPLHINKSGN NQGDTESPSH EKLVDSTFTP SSYSSSGSNA NINNANNTAL CRFPSPPNFP
     STVSTVEGHG TPLSPTIRVQ EAPWKLGSKS SGSRDSQLAI VCQEEVSQGE TYDENLNEDV
     EYCSEPSLIS TEMLSYQDDE NRQLTPPENN KGEDARQSPR KGFLCSSSLG RRASFHLECL
     KRQKNQGVDV SQKTVLPLHL VHHQALAVAG LSPLLQRSHS PTMFSRLCAT PPATPCSRGW
     PEQTIPTLRL DGAESSEKLN SSFPSIHCSS WYSDRASCSS TRRARPVSLT VPSQTGGSGR
     QFHGSAGSLV EAVLISEGLM QFAQDPKFIE VTTQELADAC DMTIEEMENA ADNILNEVPH
     CSRDLE
//
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