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Database: UniProt
Entry: A0A151NIK6_ALLMI
LinkDB: A0A151NIK6_ALLMI
Original site: A0A151NIK6_ALLMI 
ID   A0A151NIK6_ALLMI        Unreviewed;       811 AA.
AC   A0A151NIK6;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   25-OCT-2017, entry version 5.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=Y1Q_0024220 {ECO:0000313|EMBL:KYO36489.1};
OS   Alligator mississippiensis (American alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO36489.1};
RN   [1] {ECO:0000313|EMBL:KYO36489.1, ECO:0000313|Proteomes:UP000050525}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO36489.1};
RX   PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA   St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y.,
RA   Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A.,
RA   Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D.,
RA   Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J.,
RA   Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y.,
RA   Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E.,
RA   Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J.,
RA   Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W.,
RA   Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D.,
RA   Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.;
RT   "Sequencing three crocodilian genomes to illuminate the evolution of
RT   archosaurs and amniotes.";
RL   Genome Biol. 13:415-415(2012).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KYO36489.1}.
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DR   EMBL; AKHW03002956; KYO36489.1; -; Genomic_DNA.
DR   Proteomes; UP000050525; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 2.
DR   Pfam; PF01496; V_ATPase_I; 2.
DR   PIRSF; PIRSF001293; ATP6V0A1; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000050525};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    400    428       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    448    468       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    547    568       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    574    594       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    644    664       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    750    775       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       53     80       {ECO:0000256|SAM:Coils}.
FT   COILED       95    129       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   811 AA;  93745 MW;  93A2842C7C29F297 CRC64;
     MVSRFKVEVE VVPEFFRLHK KQVKKNQHEQ DGLSERGDFR DLNMNVNSFQ RKFVNEVRRC
     ESLERILRFL ENEMENETVI IKSEKYPETP LPREMIDLET VLEKLEAELQ EANQNQQTLK
     QNFLELTELK HLLKKTQDFF ETETSLPDDF FSEDTSGLLE LRSTPAAAAA KLGFTAGVIK
     RERMVPFERL LWRACRGNVY LRYTEMDTPL EDPVTREEVK KNVFIIFYQG EQLRQKIKKI
     CEGFRATMYP CPESATERRE MVDGVNTRIE DLNTVITQTE SHRQRLLHEA AVNLWTWGIK
     VKKIKAIYHI LNLCNIDVTQ QCVIAEIWFP VVDTGRIKRA LKQGMERSGS TIAPILTAVQ
     TKMSPPTFNR TNKFTAGFQN IVDAYGVGNY REMNPAPYTI ITFPFLFAVM FGDCGHGAVM
     LGFALWMVTN EKALLAQKST NEIWNTFFSG RYLILLMGIF SIYTGFIYND CFSKSLNIFG
     SSWHIRPMFS NSTWNKHVLE ENEALQLDPA VPGVYSGNPY PFGIDPIWNI AKNKLTFLNS
     YKMKMSVVMG ITQMVFGVIL SLFNHIYFRR TINIVLQFIP EIIFILCLFG YLLFMIIFKW
     CYYNVHVSQY APSILIHFIN MFLFNYNDPT NSPLYTHQKE VQSFLVIFAL IAIPWMLLIK
     PFILRANHLK AQRMLQLPPI SEGPAGDTEV EITEPNNSKK AGRENHSSGH GGHDDHEEEF
     NFGDIFVHQA IHTIEYCLGC ISNTASYLRL WALSLAHALL TIAILLVMEG LSAFLHALRL
     HWVEFQNKFY MGAGYKFSPF SFYDIINGTE E
//
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