ID A0A151NIP4_ALLMI Unreviewed; 640 AA.
AC A0A151NIP4;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform C {ECO:0000313|EMBL:KYO36672.1};
GN Name=PIK3C2G-1 {ECO:0000313|EMBL:KYO36672.1};
GN ORFNames=Y1Q_0024348 {ECO:0000313|EMBL:KYO36672.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO36672.1};
RN [1] {ECO:0000313|EMBL:KYO36672.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO36672.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO36672.1}.
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DR EMBL; AKHW03002956; KYO36672.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151NIP4; -.
DR STRING; 8496.A0A151NIP4; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR002420; PI3K-type_C2_dom.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF29; PHOSPHATIDYLINOSITOL 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00792; PI3K_C2; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51547; C2_PI3K; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KYO36672.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 200..372
FT /note="C2 PI3K-type"
FT /evidence="ECO:0000259|PROSITE:PS51547"
FT DOMAIN 343..519
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 592..640
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 640 AA; 73328 MW; 6384F2248431F091 CRC64;
MNNRSGDART PFPVSYGETY LTDSSTRFTL DPLWPRTSEN SINSKELAGW SIQLVEVDQG
SNESTASFCS AVKKTGAACS ANSADIPRSC RPGRVRGDQT LGSHDSLRKA ATSIQLHLQK
GTSFQQSLAR THEDDQSQFN LNQLLGYPCI WKLSRQNLVA ITMKYEHQLE QLLQNEHQQH
KVDSVIEEIK AICSALSSVE TRDITDAVEK LHSVLLGKAQ LQSFFFFLFI NLWWEDNISN
EELQKYTSKK SFFFLANWNE KVTFPLRIKS LPRETILAIK LYGVNYASQN TEVLAWTCCP
LYPKQVQHLA VTRIVEVTCQ KSPGKVNDRE GSFMELCCSA WHCTITFQQQ CSHRVSVTRV
CQHQSHCRLS EQKRRFLWFY RSYCNNENCS LPLVLGSAPS WDRKAILEMY AVLKNWRFSN
PLKALGLLTF SFPDQDIRRT AVQQIENLSN DELLEYLPQL VQVIKFEWSL ESPLVQFLLN
RCLQSIQVTH QLYCILKRLL KDAQNEAHFK GWYQKLLAAL QFCAGKTLND EFSKERKLIK
ILGGIAEKVK AVTNPRRQEV LKMEINRLKQ FFQEVNVCRL PLNPALVVQG IDSNTSSYFT
SSAFPLKISF INADTASRNI NVIFKMGDDL RQDMLVLQII
//
