ID A0A151NJ63_ALLMI Unreviewed; 759 AA.
AC A0A151NJ63;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=MutS protein-like protein 4 isoform B {ECO:0000313|EMBL:KYO36836.1};
GN Name=MSH4 {ECO:0000313|EMBL:KYO36836.1};
GN ORFNames=Y1Q_0020871 {ECO:0000313|EMBL:KYO36836.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO36836.1};
RN [1] {ECO:0000313|EMBL:KYO36836.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO36836.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO36836.1}.
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DR EMBL; AKHW03002907; KYO36836.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151NJ63; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR PANTHER; PTHR11361:SF21; MUTS PROTEIN HOMOLOG 4; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525}.
FT DOMAIN 579..595
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 13..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 759 AA; 85213 MW; 230E35EC78CF3E63 CRC64;
MCRGVSARLV HDTRTAGSTS AAGDGERGSA RPAFTSSSAV SAHNTASVIV AVVEGRGLAR
GEVGMASIDL KNPQVILSQF ADNSTYAKVV TKLKILTPLE IIMSNTACDA GNATKLFSLI
TDNFKNVTFS TVQRKYFNET KGLEHIEQLC ASEFSTVLME VQSKYYCLAA VAALLKYVEF
IQNSVYAPKS LKVCFQGSEQ TAMIDSSSAQ NLELVTNNRD SRNRHTLFGI LNYTKTPGGS
RRLRSNILEP LVDAETINTR LDCVQELLQD EELFFSLQEV ISRFLDTEQL LSVLVQLPKQ
DTVKAAESKI TNLIYLKHTL ELVDPLKAAL RSCKTPLLKA YYSSLEDKRF GIILEKVKTV
INDDTRYTKG CLNMRTQKCY AVRPNINEFL DIARRTYTEI VDDIAGMIAQ LAEKYNLPLK
TSFSSSRGFF IQMNADSAVL SNGQLPSEFT KIMKIKNTYS FTSADVIKMN ERCQESLREI
YHMTYLIVCK LLSEVYEHIH CLYKLSDTVS MLDMLLSFAH TCTISDYGSY VPADYSSFRI
AEQIFTRIGM DDDIETNAST FMKEMKEIAY IIQNANDRSL IIIDELGRGT STEEGIGICY
AVCEYLLSLK AFTLFATHFL ELCQIDALYP NVENNHFEVQ HVRSSTGNEE KIAYTYTLSK
GHTEEKNYGL KAAEVSSLPP SIILDAKNIT NHITRQILQR QRSTPETLRQ RAVYHLATRL
VQTARNSRLD PDSLRIYLKG LKKKYEADCP VFGQTEGQL
//
