ID A0A151NNN8_ALLMI Unreviewed; 1113 AA.
AC A0A151NNN8;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase {ECO:0000256|ARBA:ARBA00012981};
DE EC=3.1.3.86 {ECO:0000256|ARBA:ARBA00012981};
GN ORFNames=Y1Q_0015641 {ECO:0000313|EMBL:KYO38393.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO38393.1};
RN [1] {ECO:0000313|EMBL:KYO38393.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO38393.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-
CC trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
CC inositol-3,4-bisphosphate) + phosphate; Xref=Rhea:RHEA:25528,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57658,
CC ChEBI:CHEBI:57836; EC=3.1.3.86;
CC Evidence={ECO:0000256|ARBA:ARBA00023377};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25529;
CC Evidence={ECO:0000256|ARBA:ARBA00023377};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase
CC family. {ECO:0000256|ARBA:ARBA00008734}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO38393.1}.
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DR EMBL; AKHW03002524; KYO38393.1; -; Genomic_DNA.
DR RefSeq; XP_019343430.1; XM_019487885.1.
DR RefSeq; XP_019343431.1; XM_019487886.1.
DR AlphaFoldDB; A0A151NNN8; -.
DR STRING; 8496.A0A151NNN8; -.
DR GeneID; 102576763; -.
DR KEGG; amj:102576763; -.
DR eggNOG; KOG0565; Eukaryota.
DR OrthoDB; 21647at2759; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034485; F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0002376; P:immune system process; IEA:UniProtKB-KW.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro.
DR CDD; cd10343; SH2_SHIP; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR000300; IPPc.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR46051:SF2; PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2; 1.
DR PANTHER; PTHR46051; SH2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00128; IPPc; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 6..102
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 107..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 878..902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 962..1000
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1028..1113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 962..990
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1078..1092
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1099..1113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1113 AA; 124722 MW; F753BBF58ACCFE97 CRC64;
MTAASWYHRD ISRVVAEDLL AKAGKDGCFL VRDSESVSGA YALCLLFQRH VHTYRILPDE
EGLLSVQTIQ GIQAKCFRTL TDLISTYQQP NNGLVTPLLY PVNRVREPAD EDSDGEDGRA
FYPPSLASHS GAGTGSGWAT TQSNKMQISQ QLHLRLQEQV HSSPASDFMG FMAEYLNHHL
QLDLEALRNG NLQLRHLSMA LVTACRGLHS EIDFTLAGLE TLAKVFDSPA SPRSPVREQG
LLASDPDLEL LLSKISTVNH LLSSLEKKVL KSLQETVSRH NLALPSMAVA QTQSPAAKPM
AVQSFEVKVG KLQKATLTVD VEAGTVAIMK RGSSSPEETI TQDKILQLIK YQSMQTKVRL
VYDREQHRNL IRDFLFQNAR KREAFCQLLQ LMKIQHSSLD EPDLISVYVG TWNMGSAPPP
RSLASWLTSR GLGRTHDETT ACIPHDIYVI GTQENSLGDR EWVEFLRASL KTLMAIDFRV
VALQCLWSIK IVVLVKPEHE RRISHVNTSS VKTGIANTLG NKGAVGVSFL FNGTSFGFVN
CHLASGSEKI HRRNQNYSDI LRSLVLGDKR LSGFDLTLRF THLFWFGDLN YRLSMDVQDI
LARVNKKEFE TLLVVDQLNL EREKSKVFLR FNEADISFPP TYRYERGSRD TYVWQKFKHT
GMRINVPSWC DRILWKSQPE THVICNAYGC TNDIMTSDHS PVFATFEVGV MSQFVPKKAP
GSSPESLACI EWDSIEVIVK TASRSRCYIE FYSSCLEESQ RSGENSSQNS DIPGFLKLSW
SAKQLPVLNP ILSDLEYLLD QHLLLSVKGV DGCESYGECC IAMRSMISSL AQQFETFLYH
RGEETGSMRG WMKVRVPKDR RSTRERLYEW ISFETDATES PEDTSPCTKP SQHSVRSRPF
SFPETASSYT NPAYFIFEGV PNTWTLGTNL PEPPYSSASD VQEEACLGHV PGHRLRSLAG
EQTCSSGEPL QRSPHYSVPV STSYGHQLSP LQSGRHKRPK SALLLRDMPA SSDCSLTALH
LAKHLSDLDT EPHKRGSCLG TSQLKSRKNP LRHTRSALEP PPQDFQEGTV FLQSSHQLSH
DLERHRRTGP VGSRSAEPHS PRAPQSQASQ EQL
//