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Database: UniProt
Entry: A0A151NT93_ALLMI
LinkDB: A0A151NT93_ALLMI
Original site: A0A151NT93_ALLMI 
ID   A0A151NT93_ALLMI        Unreviewed;       623 AA.
AC   A0A151NT93;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=TRAF-type zinc finger domain-containing protein 1 {ECO:0000256|ARBA:ARBA00040410};
GN   Name=TRAFD1-1 {ECO:0000313|EMBL:KYO39685.1};
GN   ORFNames=Y1Q_0018729 {ECO:0000313|EMBL:KYO39685.1};
OS   Alligator mississippiensis (American alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO39685.1};
RN   [1] {ECO:0000313|EMBL:KYO39685.1, ECO:0000313|Proteomes:UP000050525}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO39685.1};
RX   PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA   St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA   Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA   Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA   Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA   Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA   McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA   Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA   Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA   Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA   Ray D.A.;
RT   "Sequencing three crocodilian genomes to illuminate the evolution of
RT   archosaurs and amniotes.";
RL   Genome Biol. 13:415-415(2012).
CC   -!- FUNCTION: Negative feedback regulator that controls excessive innate
CC       immune responses. Regulates both Toll-like receptor 4 (TLR4) and
CC       DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway
CC       by direct interaction with TRAF6 and attenuation of NF-kappa-B
CC       activation. May negatively regulate the RLH pathway downstream from
CC       MAVS and upstream of NF-kappa-B and IRF3.
CC       {ECO:0000256|ARBA:ARBA00037636}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KYO39685.1}.
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DR   EMBL; AKHW03002185; KYO39685.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A151NT93; -.
DR   eggNOG; ENOG502QQRU; Eukaryota.
DR   Proteomes; UP000050525; Unassembled WGS sequence.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR   InterPro; IPR049439; TRAFD1-XIAF1_Znf.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR001293; Znf_TRAF.
DR   PANTHER; PTHR16295:SF19; TRAF-TYPE ZINC FINGER DOMAIN-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR16295; TRAF-TYPE ZINC FINGER PROTEIN-RELATED; 1.
DR   Pfam; PF21366; TRAFD1-XIAF1_ZnF; 1.
DR   PROSITE; PS50145; ZF_TRAF; 1.
PE   4: Predicted;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00207};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00207};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00207}.
FT   DOMAIN          58..133
FT                   /note="TRAF-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50145"
FT   ZN_FING         58..133
FT                   /note="TRAF-type"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00207"
FT   REGION          243..268
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          446..485
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          522..547
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          571..623
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        252..268
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        461..485
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        571..592
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   623 AA;  69981 MW;  5FAFB45BDA1275C2 CRC64;
     MQHIAVVIIH TISRPGRGVR AGGAETGDDM DVSVGTEQET RLCSNCKKDV PVANFTIHEL
     HCSRNIEVCG FCKESVPKSE MKNHVESKHV KVTCKCNMKI EKSDLEDHEA SSCPLRPAVC
     QYCDIELAFN KLQDHEEYCG TRTETCSGCG RNIMVKDLKL HAEVCGKEAK QKQVNKARAL
     FSCEDEEAEP CSFQSIRNIL SPDDYVRTLW GMPRPLQSPF YSSFGRDQLF KDINTRTASS
     MWRDQNRVAE REQLQRNQNT ESSLSEEQNS NFDYMLALSL QSENNPHDTT STEIRSDFWK
     NYSKGAKPPE HLNRINKSDT FLHEPLVSNI TNHLKNDDVI MLPCEFCEEL YPEEDLILHQ
     TGCNPASALA SFSKRSFSPT RQGYGGLVKD DLELDRTSFG SRSSYPGQDE AVQTEGSTVI
     PCEFCGIQLE EEVLFHHQDQ CDLYPATANP TQGLSQHPLP PKDNTERRES PELVRRMRHQ
     GEVSPRYLED IGQQKLTNAV RGERSLNNLA VARDLQLTSS NTVKMNNALS PKTKPSNLGG
     GEGRVRGIGA DESAAAHVSV VRPSRNFHPE SYVSSFSRMP PTLPSVRNEA GRSQRMPNVP
     GHFRSRSTKV KPQTPESSYP EEE
//
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