ID A0A151NT93_ALLMI Unreviewed; 623 AA.
AC A0A151NT93;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=TRAF-type zinc finger domain-containing protein 1 {ECO:0000256|ARBA:ARBA00040410};
GN Name=TRAFD1-1 {ECO:0000313|EMBL:KYO39685.1};
GN ORFNames=Y1Q_0018729 {ECO:0000313|EMBL:KYO39685.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO39685.1};
RN [1] {ECO:0000313|EMBL:KYO39685.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO39685.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- FUNCTION: Negative feedback regulator that controls excessive innate
CC immune responses. Regulates both Toll-like receptor 4 (TLR4) and
CC DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway
CC by direct interaction with TRAF6 and attenuation of NF-kappa-B
CC activation. May negatively regulate the RLH pathway downstream from
CC MAVS and upstream of NF-kappa-B and IRF3.
CC {ECO:0000256|ARBA:ARBA00037636}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO39685.1}.
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DR EMBL; AKHW03002185; KYO39685.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151NT93; -.
DR eggNOG; ENOG502QQRU; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR049439; TRAFD1-XIAF1_Znf.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR001293; Znf_TRAF.
DR PANTHER; PTHR16295:SF19; TRAF-TYPE ZINC FINGER DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR16295; TRAF-TYPE ZINC FINGER PROTEIN-RELATED; 1.
DR Pfam; PF21366; TRAFD1-XIAF1_ZnF; 1.
DR PROSITE; PS50145; ZF_TRAF; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00207};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00207};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00207}.
FT DOMAIN 58..133
FT /note="TRAF-type"
FT /evidence="ECO:0000259|PROSITE:PS50145"
FT ZN_FING 58..133
FT /note="TRAF-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00207"
FT REGION 243..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 446..485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 522..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 571..623
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..485
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..592
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 623 AA; 69981 MW; 5FAFB45BDA1275C2 CRC64;
MQHIAVVIIH TISRPGRGVR AGGAETGDDM DVSVGTEQET RLCSNCKKDV PVANFTIHEL
HCSRNIEVCG FCKESVPKSE MKNHVESKHV KVTCKCNMKI EKSDLEDHEA SSCPLRPAVC
QYCDIELAFN KLQDHEEYCG TRTETCSGCG RNIMVKDLKL HAEVCGKEAK QKQVNKARAL
FSCEDEEAEP CSFQSIRNIL SPDDYVRTLW GMPRPLQSPF YSSFGRDQLF KDINTRTASS
MWRDQNRVAE REQLQRNQNT ESSLSEEQNS NFDYMLALSL QSENNPHDTT STEIRSDFWK
NYSKGAKPPE HLNRINKSDT FLHEPLVSNI TNHLKNDDVI MLPCEFCEEL YPEEDLILHQ
TGCNPASALA SFSKRSFSPT RQGYGGLVKD DLELDRTSFG SRSSYPGQDE AVQTEGSTVI
PCEFCGIQLE EEVLFHHQDQ CDLYPATANP TQGLSQHPLP PKDNTERRES PELVRRMRHQ
GEVSPRYLED IGQQKLTNAV RGERSLNNLA VARDLQLTSS NTVKMNNALS PKTKPSNLGG
GEGRVRGIGA DESAAAHVSV VRPSRNFHPE SYVSSFSRMP PTLPSVRNEA GRSQRMPNVP
GHFRSRSTKV KPQTPESSYP EEE
//