ID A0A151NXP9_ALLMI Unreviewed; 1212 AA.
AC A0A151NXP9;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Eukaryotic translation initiation factor 5B {ECO:0000256|ARBA:ARBA00013824};
DE AltName: Full=Translation initiation factor IF-2 {ECO:0000256|ARBA:ARBA00032478};
GN Name=EIF5B {ECO:0000313|EMBL:KYO41430.1};
GN ORFNames=Y1Q_0006242 {ECO:0000313|EMBL:KYO41430.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO41430.1};
RN [1] {ECO:0000313|EMBL:KYO41430.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO41430.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007733}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO41430.1}.
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DR EMBL; AKHW03001628; KYO41430.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151NXP9; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd03703; aeIF5B_II; 1.
DR CDD; cd16266; IF2_aeIF5B_IV; 1.
DR CDD; cd01887; IF2_eIF5B; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR InterPro; IPR029459; EFTU-type.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43381:SF4; EUKARYOTIC TRANSLATION INITIATION FACTOR 5B; 1.
DR PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF14578; GTP_EFTU_D4; 1.
DR Pfam; PF11987; IF-2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|EMBL:KYO41430.1};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525}.
FT DOMAIN 621..838
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 1..615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..174
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..272
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..322
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..403
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..451
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..493
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..516
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..556
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..615
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1212 AA; 137320 MW; B887C0C70CD2D676 CRC64;
MGKKQKGKSE DSAKDDIDID ALAAEIEGAG AAKEQEPQKS KGKKKKEKKK PDEDDILKEL
EELSIETQGG KADKEPSTAE NDNEEISLSK QDKKKRGKGK KASFDNDFDS EDMEDKDTKA
KKTQKTKTEA LSCSDDDDFE SLLKKGKGKM QKSSKKQDLS EDEANSKKSK EHAQAASTGE
SGDESDEFSR SKKGQKKNQK AKPSPVAESD DEEEEPTFKV KTMAQKKAEK KEREKKKREE
EKAKQRKQKE KEETEGGKEQ TKQKEVPKKG EEISSDTMTA PATGEAPTTA EDDNEGDKKK
KDKKKKKVEK EEKEKKKGPS KATVKAMQEA LAKMKEEEER AKREEEERLR RLEELEAKRK
EEERLEQERK ERKKQKEKER KERLKKEGKL LTKSQREARA RAEATLKLLQ AQGVEVPSKD
SVPKKRPIYE DKKKKKQQQQ QESKEETVEV TSPPEEVAEP DIPVQEETPP PEEPVLEEKE
EEEVEDTGLD DWEAMVSDED REKESKPVHI EVKESNDLQE EDEEEEEEED DDDEEDSEES
EEGESEGSDD EDEKTSDERE TESRAIGKQA VEKKRGKEIS SDSECDSDDD RSKEERAYDN
AKRRIEKRRA ENSKNVNTEK LRAPVICVLG HVDTGKTKIL DKLRHTHVQD SEAGGITQQI
GATNVPLEAI NEQSKMVKNF DRDTVRIPGM LIIDTPGHES FSNLRNRGSS LCDIAILVVD
IMHGLEPQTI ESINLLKSKK CPFIVALNKI DRLYDWKKSP DTDVAVTLKK QKKNTRDEFE
ERAKAIIVEF AKQGLNAALF YENKDPRTFV SLVPTSAHTG DGMGSLIVLL VELTQTMLTK
RLAQCEELRA QVMEVKALPG MGTTIDVILI NGRLKEGDTI IVPGVEGPIV TQIRGLLLPP
PMKELRVKNQ YEKHKEVVAA QGVKILGKDL EKTLAGLPLL VAYKEDEIPV LKDELIHELK
QTLNAIKLEE KGVYVQASTL GSLEALLEFL KTSEVPYAGI NIGPVHKKDV MKASVMLEHD
PQYAVILAFD VRIERDAQEM ADSLGVRIFS AEIIYHLFDA FTKYRQDYKK QKQEEFKHIA
VFPCKMKILP QFIFNSRDPI VMGVLVEAGQ VKQGTPMCVP SKNFVEIGIV TSIEINHKPV
DVAKKGQEVC IKIEPIPGES PKMYGRHFEA TDILVSKISR QSIDALKDWF RDEMQKSDWQ
LIVELKKVFE II
//
