ID A0A151P6F2_ALLMI Unreviewed; 1406 AA.
AC A0A151P6F2;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Alpha-2-macroglobulin-like protein 1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=Y1Q_0010454 {ECO:0000313|EMBL:KYO44646.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO44646.1};
RN [1] {ECO:0000313|EMBL:KYO44646.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO44646.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. {ECO:0000256|ARBA:ARBA00010952}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO44646.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AKHW03000695; KYO44646.1; -; Genomic_DNA.
DR eggNOG; KOG1366; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd02897; A2M_2; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 2.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR041813; A2M_TED.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR040839; MG4.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF178; ALPHA-2-MACROGLOBULIN-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF17789; MG4; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 423..573
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 690..779
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT DOMAIN 1314..1401
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
SQ SEQUENCE 1406 AA; 156806 MW; 92D6A593ECE7A9C8 CRC64;
MCRHYLAVIP ADLHYPSVQV ACLHITCNEE KIYAMLSIEQ SEGYDVLVHN EIQQKRSFMC
SKFQVSPPAG GTEEVATIKL FITGRRISIS EEKKVLIHRL GTGTFIQTDK PIYKPGQTVK
FRIVTMNEDF IALNNSDPNN NRIGQWLDVV AQDGIADLSF QLAAEPPLGM YVINVANGKA
YSSFSVEEYV LPKFEVVFEK PIHIYILDKT FPLQVCGRYT YGKGVQGGME VTLCRKRWSL
PSPDKSDLCK SYLSQTDKMG CFSTSVNLGD FLQVSSNFRD SIDAMVTLKE IDTGVQVNAS
GNFFISRTAG RATFEEANPY YYSGEVYTGK VKMVDHQGRL MNNTNVYLIV NYKGKQFTAM
FTTDNSGRAY FELDTNAWGD NPVSLEGRFL PQDPEYVPGT AGVVYQNAYH FIQPFYTTTE
SFLRIVRVPE ILPCGKMQQV KVDYKIDPRD LMHGSKHMTF SYYVTGKKGL ILSGQKSVWV
GLPSMMSGHF FIPLVFTSDY APAPTIIVYV IFPTGGIIAD SAPFSVSMCF KNKVKLGFSE
EEALPGSDVS LQMQAAPGSV CAVRAVDQSV LLMRPEKELS NSVIYGLFPY IYRSGYPYQV
SEDNYCWFPD AQQPDVFTLF KAMGLKILSN TNIQKPRECL ITTPKPYMWD EIRPFLQTFS
MTGTTTTLGI TTPMPVPTIE EKVRKYFPET WIWDLFPIGP KGNRNVTVTV PDTITQWKAG
MFCTAENGFG LAPTTSLRTF KPFFVKPTLP YAVIRGETFV LKATVFNYLP KCIMIQVTLA
ESSNYQLELC KSCLYTTCLC GNEAKTFQWE VTPTYLGLVN ITLSTEALAT KELCGKERPF
VPARGRTDTL IKPLLVQPEG VLVEKAHSSL LCPKEGNPVQ ALVPLKLPSN VVKGSARATV
SIIGDIMGIA LQNLDQLVKM PQGCGEQNMV LFAPIIYVLQ YLEKTGQLTP EIRDRATGFL
CSGHQRQLLY KHHDGSYSAF GTRDEDGNTW LTAFVAKCFE QAKRYIFLDD RNVRDALSWI
QLHQLPNGCF ESVGKLFNTA IKGGVDGEVP LAAYITAAYL ETGEMVNSSV VQKALGCLTQ
ALPNITSTYT KALLAYAFTL AQDTQHMKQL FQELDQKAIK AGGQIHWSQA PSKPPSTSTW
SQPQSVDVEL TAYMLLALLS KPVTRADIAT ASGIVAWLTK QQNAYGGFAS TQDTVVALQA
LAKYAALTYS KEADLEVMVT SQGSFERKFH ITHKNRLLLQ QETLTEVPGK YSLQAKGRGC
VFAQMVLRYH KPPPQASVTF ALHITTELVN CNSRDVSILT LHVSVSYIGR RVVSNMVIVE
VSLLSGFILA SSSSTSLQQN PLVRRMEMSR SSVSIYVDQL SNTSQTYALK LEREIKVTNL
KPRHIKVYDY YQPEEQALAE YRAVCS
//
