ID A0A151PCJ2_ALLMI Unreviewed; 1517 AA.
AC A0A151PCJ2;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=MAM and LDL-receptor class A domain-containing protein 1 isoform B {ECO:0000313|EMBL:KYO46772.1};
GN Name=MALRD1 {ECO:0000313|EMBL:KYO46772.1};
GN ORFNames=Y1Q_0014383 {ECO:0000313|EMBL:KYO46772.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO46772.1};
RN [1] {ECO:0000313|EMBL:KYO46772.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO46772.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO46772.1}.
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DR EMBL; AKHW03000487; KYO46772.1; -; Genomic_DNA.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 6.
DR CDD; cd06263; MAM; 6.
DR Gene3D; 2.60.120.200; -; 6.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 6.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR000998; MAM_dom.
DR PANTHER; PTHR23282; APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR; 1.
DR PANTHER; PTHR23282:SF146; ENDOSOMAL GLYCOPROTEIN PRECURSOR, PUTATIVE-RELATED; 1.
DR Pfam; PF00057; Ldl_recept_a; 4.
DR Pfam; PF00629; MAM; 6.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00192; LDLa; 7.
DR SMART; SM00137; MAM; 6.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 6.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 5.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01209; LDLRA_1; 4.
DR PROSITE; PS50068; LDLRA_2; 6.
DR PROSITE; PS50060; MAM_2; 6.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|SAM:Phobius}; Receptor {ECO:0000313|EMBL:KYO46772.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1407..1430
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 32..196
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 243..407
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 471..644
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 693..853
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 907..1063
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 1114..1279
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 1355..1389
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 224..239
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 453..468
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 652..664
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 659..677
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 871..883
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 878..896
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 890..905
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1079..1097
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1091..1106
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1379..1388
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1517 AA; 168987 MW; 593CEE7989F47956 CRC64;
MPTPFQIILQ AIVPSKNATV AIDDISLTTE SAKCDFEIDN CGWSETVSTD AFDWVRSSRS
GLPSAFQKQA PERDHTYNKS EGHFMFILQN GSSISQVAQL RSPRFSQTGS DCTVSFWYYN
YGVSVGAAEM QLHIDGLKDP TVLWRIYYNQ GYQWLKAFIQ LGRLPWSFQL SLDKISLGFY
DGVSAIDDIT FENCALPPPA VSCDTHDHFW CRDTRACIDS SLVCDLVDNC GDGSDEENCN
PELQCNFENG LCNWEQDTED DFDWIRKQGP TPTFYTGPLK DHTFGTIKGH YLYMESSEPH
VFQNTAALLS PIFNATSPDG NKKCIFRFHY HMFGKQVYSL SIFQRIVSNT KGHLLWYKFG
NQGNRWIRET VYITSPEPFQ ILVEGTVGDG FTGDIGIDDL SFKDCILYNG ILPTASTTPS
GTRIPPTLPT NNCTEKEFVC RATGHCIQRI QKCDFRPDCS DESDESSCAM IFCDFEDKGL
CEWYQLATEV AAATVSVYTT NTFQWSLGNG ASVHPGEEKC RPPNDHTAAT REGWYLYADS
SNGNFGHTAD IATPVISLTG PNCKLVFWNY MNGATVGSLQ VLSKIGNVTS ELWAQSGSQG
AQWNRAEVFL GVRSDFQVVF RAKRGVSYLG DVAVDDISFE DCSPLLIPDR PCTSEEFTCA
NKYCIPKDNL CDFMNDCADN SDESPNICST SIGRCDFEFD LCDWEQSRKD DFDWNLRTGS
TPKIGTGPTA DHTLQGPSGH YIFIKSSFPQ LPEQKARISS PMLSGNSKNC KILFYYHMYG
ASIGSLIVYQ VTSSGQEKVL LNLTGNQGNY WQRHILGLDA DEDFQVTFEG HVGKGPKGDI
ALDDITFTKE CLPSTDVSLE EPSALPPTGS CSHGYWECQN GKCYRPEQSC DFADDCGDNT
DENECGTSCT FERGRCGWQN SLTDNFDWTL GDGSPQSLRP PKDHTLGNKN GQFLYLEATP
IGLRGEKAHV KSSRWKESRS DCMMSFWYFK SSKATGDIHV LIKTDNGISR IWSESRNHAG
EWKKAEIHLG KLRNFEVLFE GIRAKDLGGG AAIDDIEFKN CSTIGESPRE CPAITDFVCW
NKNCIESHLV CDYKPDCEDQ SDEADCSHYT SIPGSCNFET QDQEWTVMCG FTQDVGDTFD
WSIGNSSITK QNGSGADHTP GNGQHFLYVN SSSQKTGDTT RIVTTSFFPA SLGVCRIRFW
FWLCDSRQTG SLKVYTVEEH GMDILMWSSS RKKERTWMYA NVVLSSNSPF KVAFEAEVGA
NELTEFALDD ISFTPECMAG VPFPDCKDHN GEETGSRCDG VPDCQLNEDE VDCPIKDCFN
GSLLCTSTNR CIPLSQRCDG ISNCIDFNLD ESSCSDCPDG YCKNGGTCII KEVIPLCQCV
EEWRGNRCHI KVTTPQAPGS ILLQNGIWTG LGVGLTLLLI EIAVIVFCFL SKRKMPKTKQ
EEIPTTSFAN PLYEDCSSSR EQEPTAYVTS PSVQISVSPW QTLQENSSNK DQHVPSFANP
LYGKAIGKME NLHNTLK
//
