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Database: UniProt
Entry: A0A151PCJ9_ALLMI
LinkDB: A0A151PCJ9_ALLMI
Original site: A0A151PCJ9_ALLMI 
ID   A0A151PCJ9_ALLMI        Unreviewed;      1163 AA.
AC   A0A151PCJ9;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   25-OCT-2017, entry version 11.
DE   SubName: Full=Potassium voltage-gated channel subfamily H member 8 isoform A {ECO:0000313|EMBL:KYO46654.1};
GN   Name=KCNH8 {ECO:0000313|EMBL:KYO46654.1};
GN   ORFNames=Y1Q_0018414 {ECO:0000313|EMBL:KYO46654.1};
OS   Alligator mississippiensis (American alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO46654.1};
RN   [1] {ECO:0000313|EMBL:KYO46654.1, ECO:0000313|Proteomes:UP000050525}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO46654.1};
RX   PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA   St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y.,
RA   Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A.,
RA   Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D.,
RA   Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J.,
RA   Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y.,
RA   Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E.,
RA   Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J.,
RA   Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W.,
RA   Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D.,
RA   Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.;
RT   "Sequencing three crocodilian genomes to illuminate the evolution of
RT   archosaurs and amniotes.";
RL   Genome Biol. 13:415-415(2012).
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KYO46654.1}.
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DR   EMBL; AKHW03000499; KYO46654.1; -; Genomic_DNA.
DR   Proteomes; UP000050525; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR003950; K_chnl_volt-dep_ELK.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   PRINTS; PR01465; ELKCHANNEL.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00086; PAC; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   TIGRFAMs; TIGR00229; sensory_box; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS50113; PAC; 1.
DR   PROSITE; PS50112; PAS; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000050525};
KW   Ion channel {ECO:0000256|SAAS:SAAS00904115};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00903208};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00904256};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00903350};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00903851}.
FT   TRANSMEM    209    234       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    254    272       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    315    337       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    349    375       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    417    439       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    446    470       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       39     87       PAS. {ECO:0000259|PROSITE:PS50112}.
FT   DOMAIN       90    142       PAC. {ECO:0000259|PROSITE:PS50113}.
FT   DOMAIN      548    612       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
FT   COILED      859    893       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1163 AA;  130656 MW;  F93475A2142B033B CRC64;
     MKGLLAPQNT FLDTIANRFD GTHSNFILAN AQVHRGFPIV YCSDGFCDLT GFARTEVMQK
     NCSCRFLYGP ETSEPVLQRI EKVLDGKQEY QTEVCFYKKG GTAFWCLLDI LPIKNEKGEV
     VLFLFSFKDI TESRGKNHQS DRKDEKHRSK KAGSLHLRAA RRQGRTVLHQ LTSQFSRKDR
     GEMKISSNVL ENKLSIPEYK VASVQKSRFI LLHYSIFKAL WDWLILLATF YVAVTVPYNV
     CFTSTEDSLS AARSTIVSDI AVEMLFILDI ILNFRTTYVS QSGQVVYDTR SICIHYVATW
     FFVDLIAALP FDLLYAFNVT VTSLVHLLKT VRLLRLLRLL QKLDRYSQYS AMVLTLLMSM
     FALLAHWMAC IWYVIGRKEM ESNDPLTWDI GWLHELGKRL EAPYINNSVG GPSIRSAYIA
     SLYFTLSSLT SVGFGNVCAN TDAEKIFSIC TMLIGALMHA VVFGNVTAII QRMYSRRSLY
     HTRMKDLKDF IRVHRLPQQL KQRMLEYFQT TWSVNNGIDA NELLRDFPDE LRADIAMHLN
     KDILQLPLFE AASRGCLRAL SLHIKTSFCA PGEYLLRQGD ALQANYFVCS GSLEVLKDNM
     VLAILGKGDL IGADLPSKEQ VIKTNADVKA LTYCDLQYIS LRGLFEVLEL YPEYSSKFMA
     DIQQDLTFNL REGSEAEGLL RYSRSPRLSQ PRSESGNTPE KPLPSIHEDE EEPDDFFHPS
     PATITRRKLL LPNLNSPVRR GSLSSLLGDD LRQFSALRRT CRSPAHCTRG RSPSPQCRRG
     NRPSESESSN GRKPAKLLIP SLNTYGPPDL SPRLKPPLLP RVVDGIEDDG GTSETQAFHF
     NVDPPLPSST TDSPLSGTEQ ALAAEAEEIK QNVQRLNQEI SNLNREVSHL SRELQHMMHI
     LQTQLGAQPL CGPTLACPYS LHSLSSPEPS GRSLADSPEA GSALRGPLGV ENLLASASES
     RICTVPLTLA HESSALLHRN RPWQGQFHEY QESTIGAAFL TQTVCLDDTT VKFEIWDTAG
     QERYHSLAPM YYRGAQAAIV VYDITNTDTF VRAKNWVKEL QRQASPNIVI ALAGNKADLA
     SKRAVDFQDA QTYADDNSLL FMETSAKTAM NVNEIFMAIA KKLPKNEPQN APGAPGRNRG
     VDLQENSQPR QEVLKWLLLP ESN
//
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