ID A0A151PCV4_ALLMI Unreviewed; 1756 AA.
AC A0A151PCV4;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Integrin alpha-V isoform B {ECO:0000313|EMBL:KYO46605.1};
GN Name=ITGAVL {ECO:0000313|EMBL:KYO46605.1};
GN ORFNames=Y1Q_0018376 {ECO:0000313|EMBL:KYO46605.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO46605.1};
RN [1] {ECO:0000313|EMBL:KYO46605.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO46605.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO46605.1}.
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DR EMBL; AKHW03000499; KYO46605.1; -; Genomic_DNA.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF73; INTEGRIN ALPHA-IIB; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF01585; G-patch; 1.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00443; G_patch; 1.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS50174; G_PATCH; 1.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762}; Coiled coil {ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT TRANSMEM 1707..1728
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT DOMAIN 40..86
FT /note="G-patch"
FT /evidence="ECO:0000259|PROSITE:PS50174"
FT DOMAIN 136..165
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REPEAT 787..849
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 1058..1123
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 1124..1182
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 1184..1246
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REGION 166..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 224..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 277..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 730..763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1578..1602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 91..121
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 233..249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..300
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..364
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..442
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..631
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..659
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 730..746
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1756 AA; 195270 MW; CA234C7617BEB7BE CRC64;
MADRFSRFNE DRDFQGNHFD QYEEGHLEIE QASLDKPIES DNIGHRLLQK HGWKLGQGLG
KSLQGRTDPI PIVVKYDVMG MGRMEMELDY AEDATERRRV LEVEKEDTEE LRQKYKDYVD
KEKAIAKALE DLRANFYCEL CDKQYQKHQE FDNHINSYDH AHKQRLKDLK QREFARNVSS
RSRKDEKKQE KALRRLHELA EQRRQSECAP GSGPMFKTTT VAVDEEGGGD DENESAANSS
SSIQTTSSQA TEMIMDRGVL NTGQKAPVKL ESIASVFKDH VDESSPTDGT KSDDRASDQG
ALQKAGETEN TNSPDGKPDE DDSHEKDSEQ MEAENVNKKN VHDTKKGNSP KPKAGKHVEK
SAESTVQQKE LSTVELTDQK GKMETKQTPE NASVVESKRS TENDPPEPDA TKATQPAPSG
KELSRNKDAK AKGTEKSKDP VGLSKENVLS MESSDIIKGK ETGCITNSSV VKMETKSVST
CSTQNKHDSN LASASKLEGA DDSSKNLTNK KDKSSHRSRQ SSGDYDSDEG SRRKHFRQKS
LSQYSDDYDS DHSRYSRRRS YSADSYSDYS DRSRCHSKRS RSDDDSDYNS PNRRSKRHKY
SSSEDDYSLS RSRAGRSEGS LKKEESKGDE AKTSGLLSQN SSSSSLGKAS ESDCSPEERN
SVTAKLLLEK IQSRKVEKKP CSTDEMLAGA NKLGIKLKDP PQGYFGPKLP PSLGNKPVLP
LIGKLPTVRK PSTKRYEESG IERGEEQELS EPEEASPGSG EAQLAGQPLL EEVVMGPWLV
QALNLCSSHL TVYMGPDCSY FGFSMDFLQA SNGSMNIVVE APKANTSQLD VIEPGAVFLC
PWAPHGKPCY EIPFDSKRDQ VESRFHFQLK NYKSHQWFGA SVSTWKSNVV ACTPLQHWNI
FEHSALAQAT KTPVGTCFMA SNNLSHFAEY SPCRSHRMDS LYATDGYYND KRGLYVPLQT
GTLVLGAPGG YYFDGMIFAV SLSAIKSSYR GTAMIWSVKE EQVSEEVRHG YEDSYRGYLV
AVGEFDEDPR TAEYVVGVPN KYNTKGGVEI LSTYKKLQLL QNIQSEQIAS YFGHTVAVVD
VNGDGKDDIL VGAPLYMERR SDQKLYEVGR VYLYLQLGHP YSNPWQKLTG TDVYGRFGTA
IAPLGDLDQD GYMDVAVGAP FAGQGGSGRV FIYNGHSEGL QTPASQVLDS PFPGRASFGF
SVRGATDIDA NGYPDMLVGA FGAGKVAVYR AHPVVMAKTQ LSMPDVLNPE EKTCTMPNSK
TPASCFSIEI CVSMLGKSIP EEIKLNASLQ LDRMKQKSGK RIFLFQPHES TLTLKLSKEG
PPFCHHFLDY LRTRIVLDCG EDNVCIPDLR LSACKDLDYL LIGAENMVHI KADAANEGEG
AFEAELQVQL PPSAHYQRAV SNMQGMEKLI CNPQKNNETH MVICELGNPM KTGTKVTVDI
AVSVANLEDA GDTITFLLQL RSKNSQNPNS NVTVVQVPIK VAAQMELRGN SLPATMVVPL
EGWTQPEDSR WLEDYGPKVE HVYQLHNKGP GRVSGVALQV DFLSQFQSDF FLYLASHSTE
GKINCSDPAN VNPLGLDIQK PMVSPSNNES RQPAHRRERW EADEEGLPTL QEPLLLNCSS
QPCVTITCYV ESLEKDQRAM VTVHAILWMK SFMKRPHDQF IIQSQAWYNV SAMPYRIQPE
VLPSGSATAD TKLLWVSPDG KKEIPTWWIV LAVLAGLLLL AIFIFVMWKM GFFKRKRLLS
NEEDLKSDED GASQAE
//
