ID A0A151PD67_ALLMI Unreviewed; 1176 AA.
AC A0A151PD67;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Sodium channel protein type 5 subunit alpha {ECO:0008006|Google:ProtNLM};
GN ORFNames=Y1Q_0014536 {ECO:0000313|EMBL:KYO46983.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO46983.1};
RN [1] {ECO:0000313|EMBL:KYO46983.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO46983.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO46983.1}.
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DR EMBL; AKHW03000487; KYO46983.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151PD67; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 2.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 3.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF288; SODIUM CHANNEL PROTEIN; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 3.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|ARBA:ARBA00022882};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 101..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 123..147
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 489..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 519..542
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 554..576
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 597..622
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 682..705
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 932..951
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 963..982
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 988..1008
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1049..1075
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 130..235
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 264..346
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 489..714
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 721..922
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 926..1153
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 368..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 19..46
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1176 AA; 135186 MW; C667A6A625E49C09 CRC64;
MDPSLLLAAA YGFRRFTPNS LFEIENRIAE NKAKQAQAKQ DNSSQQVKEE QCSPQLDLKA
CNKLPTIYGK PSPELVGVPL EDLDPYYSDH KTFMVLNSKN IIFRFSATPA LCILGPFNPI
RRAAIKILVH SLFILFIICV VVLNCVLMAQ FPSSEQSKVT EYIFTGIYTA EISIKILARG
FVWNEFTFLR DPCDCLDFIV IIMTYISLIG PLQNVSALRT FRVLRTFKAI SVLPGDVCAR
MKNSNDILLC NPNSELKCPE NYSCEAHKPN PDFGYTSFDN FGWAFLSMFR LMTQDSWERL
YRQVIRTTGK TSMIFFVVVI FLCSFYLFNL ILAVVTMAYE EQNQATQAEI QAKEKLFQEA
EELLKKEQMK SARKTDTATT NSFKGRTTEP EGFGDDERIF HSQPAHCQKK LKKILTSYDV
SLDAVNDAYQ RQRLMSAASI ITDNMTLKRS IWKCPPSWNR FAQKYLIWQC CPLWIRIKES
VKLIGMDPLT DLFFTLCIVV NTVVLALEHP TMNQKYKDLI NIINHVFTGI FTAEMILKMI
ALDPYYYFQE HWNIFDSLIV VLGLMSIPKE INLSFLKLLR IFKLAKSWPA LNKLMKIILK
SFGALSNLTL VLIITVFIFA VVGKQVLGSY YENSTRISTD GKLRWHMKDL SHSLLIVFRI
LCGEWIETMW ECMEVAGKAR CLPVFLTVLV IGNLVVLNLF IALLLSSFSS NTQTTPEGTE
MKLQLAFDRI YSGLQFMKRI ISDQIGKILR QELTLQACQK AKMKATAPAM KMYEDFVMDT
KTSVCVPIAE EDLYSMEYDD SCSMYSTEME YGKWERHLRH REQSKSSGTL SQLSRTSASE
SMISMDTLQK ENQQKNLDAM SCSEASTVDM YTFVGNYQLA EKPSTPEDCF TEGCVRYFPF
CSVDITKYPG DTWWRFRKTC FRIVEHNWFE NFIIFMIVLS SGSLAFEDIY LENRKNIQNL
LNFADIMFTY IFFLEMILKW VAYGFQKYFT SAWCWLDFVI VWISFISFGP KSTSILEYLC
AQQSSLKSIR TLRALRPLRA LSRFEGIKVA VHALLGAIPS ILNVMLVCVV FWLLFNLIGV
NEFGGKFWKC TNISPNMNIT NKNDCVNFNV TGSLKWENTY VNFDHVGMGY LALLQVATFK
GWMDIMYAAV DSHGGLFWQQ AENLEERKFP FHLKPP
//
