ID A0A151PDR7_ALLMI Unreviewed; 425 AA.
AC A0A151PDR7;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Bone morphogenetic protein 5 isoform B {ECO:0000313|EMBL:KYO47138.1};
GN Name=BMP5 {ECO:0000313|EMBL:KYO47138.1};
GN ORFNames=Y1Q_0014037 {ECO:0000313|EMBL:KYO47138.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO47138.1};
RN [1] {ECO:0000313|EMBL:KYO47138.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO47138.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO47138.1}.
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DR EMBL; AKHW03000483; KYO47138.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151PDR7; -.
DR STRING; 8496.A0A151PDR7; -.
DR eggNOG; KOG3900; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF139; BONE MORPHOGENETIC PROTEIN 5; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 336..425
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 322..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..349
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 425 AA; 48536 MW; 1A1AD2884AE1223E CRC64;
MLISGNSSET SLIDTFLQDL KKREGGITEN VVFRDDIDLK NRRLRNHERR EIQREILSIL
GLPHRPRPFS PGKQASSAPL FMLDLYNAMT NEEDTEEMEY SLRGSLGGES RGIRKGYPAS
PNGYSRRIQL SRMTPMTTQS PPLASLHDTN FLNDADMVMS FVNLVERDKD FSHQRRHYKE
FRFDLTQIPH GEAVTAAEFR IYKDRSSSRF ENETIQISIY QIIKEYPNRD ADLFLLDTRK
AQALDVGWLV FDITVTSNHW VINPQNNLGL QLCAETGDGR SINVKSAGLI GRHGPQSKQP
FMVAFFKASE VLFRSVRAAN NKKKNQNRNK SGSHQDSSRM PSAGDYNTSE QKQACKKHEL
YVSFRDLGWQ DWIIAPEGYA AFYCDGECSF PLNAHMNATN HAIVQTLVHL IIVPYSGYIR
DYAVR
//
