ID A0A151PFP2_ALLMI Unreviewed; 403 AA.
AC A0A151PFP2;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Nothepsin isoform A {ECO:0000313|EMBL:KYO47754.1};
GN Name=NOTS {ECO:0000313|EMBL:KYO47754.1};
GN ORFNames=Y1Q_0019829 {ECO:0000313|EMBL:KYO47754.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO47754.1};
RN [1] {ECO:0000313|EMBL:KYO47754.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO47754.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO47754.1}.
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DR EMBL; AKHW03000416; KYO47754.1; -; Genomic_DNA.
DR RefSeq; XP_006275110.1; XM_006275048.2.
DR AlphaFoldDB; A0A151PFP2; -.
DR STRING; 8496.A0A151PFP2; -.
DR GeneID; 102566566; -.
DR KEGG; amj:102566566; -.
DR eggNOG; KOG1339; Eukaryota.
DR OrthoDB; 1120702at2759; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 6.10.140.60; -; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR012848; Aspartic_peptidase_N.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF37; CATHEPSINE-A-LIKE PROTEIN-RELATED; 1.
DR Pfam; PF07966; A1_Propeptide; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 2.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR601461-2};
KW Hydrolase {ECO:0000256|RuleBase:RU000454};
KW Protease {ECO:0000256|RuleBase:RU000454};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..403
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007586997"
FT DOMAIN 79..394
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT ACT_SITE 97
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 282
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT DISULFID 110..115
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT DISULFID 273..277
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT DISULFID 316..353
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 403 AA; 45152 MW; E06CA5D489DD6BA7 CRC64;
MKVILLALVY IPFTIAVERI PLVRFKSIKK QLHERGDLEV FWSNHQPDIF ARRYLHCFPS
DIFLPATSER LYDYMDAQYY GVVMVGTPPQ KFTVVFDTGS SNFWVPSAYC ISEACSVHER
FKSFLSNSYQ HGGQAFSLQY GTGQLLGIAG KDTVQISNIS IEAQDFGESV FEPGMTFALA
HFDGVLGLGY PSLAVGNALP VFDSMMNQRL VEEPVFSFHL NRGNNIENGG ELILGGIDHS
RYKGSIHWVP VTEKSYWQIH VNNVKIQGRI VFCAHGCEAI VDSGTSLITG PSSQIRRLQE
SIGASPTQTG EFIVDCRRLS SLPHISFTIG HKEYKLTAEQ YIIKESIDGR SLCISGFQSL
DIATHSGQLW ILGDVFMSVY YCVFDRGHDR VGFAKSVHRK EHL
//