ID A0A151T8U0_CAJCA Unreviewed; 540 AA.
AC A0A151T8U0;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=GPI ethanolamine phosphate transferase 1 {ECO:0000256|RuleBase:RU367138};
DE EC=2.-.-.- {ECO:0000256|RuleBase:RU367138};
GN ORFNames=KK1_018045 {ECO:0000313|EMBL:KYP63469.1};
OS Cajanus cajan (Pigeon pea) (Cajanus indicus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Cajanus.
OX NCBI_TaxID=3821 {ECO:0000313|EMBL:KYP63469.1, ECO:0000313|Proteomes:UP000075243};
RN [1] {ECO:0000313|EMBL:KYP63469.1, ECO:0000313|Proteomes:UP000075243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Asha {ECO:0000313|Proteomes:UP000075243};
RX PubMed=22057054; DOI=10.1038/nbt.2022;
RA Varshney R.K., Chen W., Li Y., Bharti A.K., Saxena R.K., Schlueter J.A.,
RA Donoghue M.T., Azam S., Fan G., Whaley A.M., Farmer A.D., Sheridan J.,
RA Iwata A., Tuteja R., Penmetsa R.V., Wu W., Upadhyaya H.D., Yang S.P.,
RA Shah T., Saxena K.B., Michael T., McCombie W.R., Yang B., Zhang G.,
RA Yang H., Wang J., Spillane C., Cook D.R., May G.D., Xu X., Jackson S.A.;
RT "Draft genome sequence of pigeonpea (Cajanus cajan), an orphan legume crop
RT of resource-poor farmers.";
RL Nat. Biotechnol. 30:83-89(2012).
CC -!- FUNCTION: Ethanolamine phosphate transferase involved in
CC glycosylphosphatidylinositol-anchor biosynthesis. Transfers
CC ethanolamine phosphate to the first alpha-1,4-linked mannose of the
CC glycosylphosphatidylinositol precursor of GPI-anchor.
CC {ECO:0000256|RuleBase:RU367138}.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|RuleBase:RU367138}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU367138}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU367138}.
CC -!- SIMILARITY: Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
CC {ECO:0000256|RuleBase:RU367138}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU367138}.
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DR EMBL; CM003609; KYP63469.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151T8U0; -.
DR STRING; 3821.A0A151T8U0; -.
DR OMA; RNNEDMK; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000075243; Chromosome 7.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051377; F:mannose-ethanolamine phosphotransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR007070; GPI_EtnP_transferase_1.
DR InterPro; IPR017852; GPI_EtnP_transferase_1_C.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR12250:SF0; GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1; 1.
DR PANTHER; PTHR12250; PHOSPHATIDYLINOSITOL GLYCAN, CLASS N; 1.
DR Pfam; PF04987; PigN; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU367138};
KW GPI-anchor biosynthesis {ECO:0000256|RuleBase:RU367138};
KW Membrane {ECO:0000256|RuleBase:RU367138};
KW Reference proteome {ECO:0000313|Proteomes:UP000075243};
KW Transferase {ECO:0000256|RuleBase:RU367138, ECO:0000313|EMBL:KYP63469.1};
KW Transmembrane {ECO:0000256|RuleBase:RU367138};
KW Transmembrane helix {ECO:0000256|RuleBase:RU367138}.
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367138"
FT TRANSMEM 118..135
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367138"
FT TRANSMEM 141..157
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367138"
FT TRANSMEM 177..198
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367138"
FT TRANSMEM 204..221
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367138"
FT TRANSMEM 230..251
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367138"
FT TRANSMEM 257..275
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367138"
FT TRANSMEM 301..319
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367138"
FT TRANSMEM 331..350
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367138"
FT TRANSMEM 362..395
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367138"
FT DOMAIN 60..439
FT /note="GPI ethanolamine phosphate transferase 1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04987"
FT DOMAIN 441..536
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|Pfam:PF00078"
SQ SEQUENCE 540 AA; 61681 MW; 2BEDAD32B7D994E3 CRC64;
MMLVSLTTSD IKQSNSLYFK PFKPLSHYSS ILDKIEGLIS AIDYDAAMDL SKNLRSLALQ
GLHYFQTYDW LMLMSVITLG YVGWMIYLVL HVLQSYTSLP GNTFGMEQAV QKNNRGKIYL
YGSMVTGMLC LLLLLEHSPP LYHAYMMMTS FLWVQIISEY QFIRTLWKHL SGRRTSYIIK
LLATTAVSVF ILEFLVNSFT ERKLYTWCFL IAGATASLYL FQSIPWRSSI SIYVCIACWF
LSLFTLMPAE IPDNNQLVVS SGVIIIIIGI IARWLDLHAG GRKYWQSICN CKFKSSKFSS
LFYLQALLVA LSSVMVYLST VHRTEKHELL ASHQLINWSV AGFSMVLPLF SENSLLSRLT
SIFLGFAPPF LLLSIGYEAI FYAALALVLM AWILFENTLL NLNIVNKSSD STKSVTNNLI
HGFDNRSLQL SDVRIPLVFT HKTTFRTFDG HYEFWVMPFG LTNAPSTFQA AMNDLFRPHL
RKFVLVFFDD ILVYSSNINN HLIHLKLVLE LLTTNKFFAK YSKCVFAEPT IAYLGHLIST
//
