ID A0A158NL89_ATTCE Unreviewed; 4836 AA.
AC A0A158NL89;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
GN Name=105621438 {ECO:0000313|EnsemblMetazoa:XP_012058297.1};
OS Atta cephalotes (Leafcutter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Atta.
OX NCBI_TaxID=12957 {ECO:0000313|EnsemblMetazoa:XP_012058297.1, ECO:0000313|Proteomes:UP000005205};
RN [1] {ECO:0000313|Proteomes:UP000005205}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21347285; DOI=10.1371/journal.pgen.1002007;
RA Suen G., Teiling C., Li L., Holt C., Abouheif E., Bornberg-Bauer E.,
RA Bouffard P., Caldera E.J., Cash E., Cavanaugh A., Denas O., Elhaik E.,
RA Fave M.J., Gadau J., Gibson J.D., Graur D., Grubbs K.J., Hagen D.E.,
RA Harkins T.T., Helmkampf M., Hu H., Johnson B.R., Kim J., Marsh S.E.,
RA Moeller J.A., Munoz-Torres M.C., Murphy M.C., Naughton M.C., Nigam S.,
RA Overson R., Rajakumar R., Reese J.T., Scott J.J., Smith C.R., Tao S.,
RA Tsutsui N.D., Viljakainen L., Wissler L., Yandell M.D., Zimmer F.,
RA Taylor J., Slater S.C., Clifton S.W., Warren W.C., Elsik C.G., Smith C.D.,
RA Weinstock G.M., Gerardo N.M., Currie C.R.;
RT "The genome sequence of the leaf-cutter ant Atta cephalotes reveals
RT insights into its obligate symbiotic lifestyle.";
RL PLoS Genet. 7:e1002007-e1002007(2011).
RN [2] {ECO:0000313|EnsemblMetazoa:XP_012058297.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (APR-2016) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; ADTU01018995; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADTU01018996; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012058297.1; XM_012202907.1.
DR STRING; 12957.A0A158NL89; -.
DR EnsemblMetazoa; XM_012202907.1; XP_012058297.1; LOC105621438.
DR GeneID; 105621438; -.
DR KEGG; acep:105621438; -.
DR eggNOG; KOG3595; Eukaryota.
DR InParanoid; A0A158NL89; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000005205; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF343; DYNEIN AXONEMAL HEAVY CHAIN 10; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005205}.
FT DOMAIN 2170..2306
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2449..2601
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2811..2999
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 113..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 365..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1105..1132
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3470..3497
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3624..3717
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 136..155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4836 AA; 561588 MW; 4EE4C2180BC406B8 CRC64;
MEENIYEKDE EKEEDEQESL RGKDRDRLSI LYMDYRIKWI CDRVLKFLGL MDQEYLFHKL
INANNRYFED KLLNFLMLDL YEVTDLEKKL IFFYKTYVSE VFQEEVSVWE ERKEEKRKKR
DRRKKGKRGK AKVNKTDINS VASTTMSTST HISSIPESSE EEEEEDRKQN DDLRKKGDLK
SVSIDTSVST PPPGEEAKYI LTKKMIEKVR QVPMLHMICG QIDDSRTDLE DITFFYFMRT
SDESIPFFDT YEECLNEITN YVVVGSLDRK FLSSLNRILV NVFKPLVENQ FRAPDIHEQT
KYVDDGKRKN IDIEMKSMLR RPSNFVTASN IISRRDTNRK ADDEENTTIS MATLQDEVLK
SRKQKSNLKG LDEKSEQSIS EFSKSDSKEI KKQPVTEQLK RDILDYLENL IEKTQWTLEH
IEGDILLTMP KISELNDPAI TDDMLVKNKD IVEQMEEIVM SWEKHIQKIM ESYESKVLQG
KGPIAVHQYW QTFETGLTML VEQLKMPFVK RILALLEQAV SPIASSFHNF QTELWKHYVE
VRNNNKFIQT LLRYFKLITE SDSFESISEC IPSMMEGLRM LWILSSYYCH EEKIMLLMDR
ISWQLCENVK QNLAIIRLFK KPLEEILEKT SMASVMLKQW KRLYLKVRLD IELSGKGARW
EFDQKRLFQN TEYIAEVCSD LHKIASVLQD FYNIFGPDLK SIINDPAQID TVVKRVDALI
VPIEEVDFDI FDVFNKENWE ALNAWFYEEV IFLEDQAKFY IDECFMVLIS AENSLEMLLK
FKNIKTRDAI QHQLFRKFNV IMQQFSKEIN VVESIYNRGK WQPPLLTYHP PMAGAIFWVK
QLFHRLRRPV LIFQEVHELK HSELKLLAFS QYFDLAKQLK NFEGVTFNAW LDKALLMVTT
TLKKSVLRII RVEREYPATL TFPDEERATK NLIHVEKMKI ISTMDSRMEQ ALPEVKVDTR
GSLKDGKASS VFFDKHDFVR AKITWPEFMS GAILIECQLR FQINFDWEIF EIIREAELME
QLGFELPATI RDVGIQKNRL RADIEVTTKM IDQYNNILDM LDRADIQLLK QILQDVEKNI
QPGETRFNWN SLTISDYAAA CYKILKNLNS IVEQVNQIKK ELDNRIESEL QSYHLFSMKK
EVNESEDLLS CKSYFMEIKN RRSELVSSML KAYQSISPML VKLESLVLGT STGTSPAMQL
LYKKYEKKIF AAFIICMVRN MEVLNKMLNS TKPIFQVDVL LITSEVILRP SPNEIFSTIC
YDVRDLLERL KEFSRWMNGT CLQCKPQTKE HSQDLVTFSF FEDVMSIRIV NELVKMVHDT
AYRISADCWR YLYRWKKYSN LWSFDKNLAC EKFAATKPTV IQYYEKFSFY EGILEELEDM
SSYFDINSIR LNLKPLLSGI EQQAKEWKQV LGNYLLSDTI LAMGQLKTQI DTFRGEIELV
VSEKDSFVSI MHAITDVKSM AIQAEVRFLC YQECFQTMRT HGIVFSSSDE AMAYELQQDW
ESLYLEALYR AATLEGTSDK FSELTEEEIQ QFLVDITKFA ENFETFGPGS IGDDLELGLK
KMSEYGKLIN KYEEKRLDLI KLENLFNLPS TDYSTLLKIK TEYEGMEVLY NLYKEQKSAR
EVWAKTLWVN LNPQQLIEGM EHFIREFRQL PKTIKNMDIG HALKTNMKNF KNSVPLFIEL
KNEAMRERHW QELMRRTGQY FDMDPDRFTL ENMFAMELGK YQDIAQDVVM YAVKELAIER
GMKELAEIWK SMEFNIVKHY KGIEERGFIL GPLDELNLVL EDNMLTVHSM AASQFVGPFL
NVVQKWERTM HTISEVLEVW VDLQRKWLYL EGIFVGGDIR FQLPDETKRF DDIDQAYRKI
MADTAKRLNV LECCLIYGRK SEFETMIAAL EKCQKSLKEY LCNKRIIFPR FNFISDDELL
NILGSGTPTT IQEHVGKMFD NLDKFIIVSD TDKQMATALV SCEREVMDFR NPVSVEDQVE
IWMGLALEEM KRSNRYLTKK AVYNYGKVRR PITQWILEFQ GMMVLVANQI WWTAEVENVF
DKISQGNKRA MKEYLQQLNT QVDEVVTLMG TDSLTNNDRK KIDMVLTINV HIRDIVESFV
RNSIVDPTEF EWESQLRFYW VHDLDNVWMN QCTGTFEYGY EYMGLNGRLV ITPLTDRIYL
TITQALSMHL GGAPAGPAGT GKTETVKDLA KALGLLCIVT NCGEGMDYIT IGKTLSGLAQ
CGAWGCFDEF NRIDSSVLSV ISTQLQTIRS ALQVKAQRFA FEDQDIVLDS KVGVFITMNP
GYAGRTELPE SIKALFRPVV CIVPDNELIC QIKLFSAGFL MAKLLAKKMT VLYKLASEQL
SKQTHYDFGL RALKSVLNMA GELKRTSNDL PENVVLMRVL RDMNLPKFIY DDVPLFLGLI
RDLFPDLDCP RMHYLDFNEA VEAVLKEHDY IVLPEQVDKV IQLYEMMMIR HSTMIIGPTG
GGKTVVVETL CRAQTYLGKP TKLHILNPKA CTVIELYGKL EPTTRDWADG LLSNIFREIN
RPLDSSKDER RYILLDGDVD ALWIENMNSV MDDNKLLTLA NQERIKLQNY CSLLFEVGDL
QYASPATVSR AGMVYVDPKS LGYQPYMDKW IQTKSNADQD FLRGMCEKYV HGSLKLITEG
MLGFQTVEPL RTIIPQTGLN MVTQFCFVFD GLLSTLKYEL EKQKSEIDEE DNLLVTKKKL
WEAMYIQACY WSFGASIVDE ARSKFDEYIK KICGFMLVED TPAKPASAKF IPVSFPTIYD
YVLDIKEKVW KAWKWLVPMY VHDRQKNFSD ILVQTIDTLR TTWFVNLMNN LQRPVLLVGE
TGTSKTAIIH EFLRNLNPEK YEQLLINFSS RTTSMDVQRN IESVVEKRSR EVFGAPPGKK
LIVFIDNMNM PIVDIYGTQQ PIAFLKLLFE KGGFYDRGRD LNWKYMKDIY YLAAMGEPGG
GRNEVDPRFI SMFSVYNVTF PTNETLNYIY TSILSGHLQT FSEAILSIAD KLVQLTLELY
EVILNELLPT PSKFHYIFNM RDLSRIMAGL LQTHPNIFFV TKQFVRLWRN EVTRVICDRL
IIVQDKNLII EQLNEKIRNC WELEPEVIQY SLRDPILYGD FRNALNKDEL RFYEDLLDYE
AVYSLFLEIF EEYNERNRTK LHMVLFNDAL EHLTRVHRVL RMHCGHVLII GTDGSGKKSV
IKLASFAADY QLFQIVLRRG YNQAFFREDI KNLYNMVGLE NKRIVFMFTS AHIKDESFLE
LVNSMLTGFM PAVFNDEEKD IIVSSCKDAA VKAGFDASKK SVWSYFAKTC TTNLRIALAM
SPSSDALRTR CRSYPGLINN TTIDWMFPWP QQALVAVANV LLRDNPIVPQ EYKEVIVSHV
VYVHTSVLQY TMDFATKLRR RNYITPWHFM DFINTYLNLL VEKKNFINSR CTRLSEGLQK
IIDASVTLTE LNEVLAEQRI KVDDQTTNCE QLLEIIGKST DIELEKKTLR EDKRKEIEEK
KKIITKEETE ARQALAEAQP ALDAAKLALS DLDKADITEI RSFPTPPEPV QIVSECVAML
RGVKDVSWKG AKGMMSDPYF LKHLQEMNCD LITLRQLQAV RAHLKKTDKL DQMQVISKAG
YGLYKFVLAV LDYCAVYREV KPTIDRVQAL EAESEKARRA LEKEERELKR LEETIKELNE
KYDAAMTKRQ NLQDETDLLQ RRLSAADKLI SGLSSENERW RKDLEVLQDD LEKITGNCLL
GAAFLAYSGP FSYEFRNEMY SDWERSILDK ELPLSTPFKF ETQLSDDIEI TNWNSEGLPP
DELSVQNGIL TLKASRFPLC IDPQQQALNW IKKREKKNLK ILSFTDADFL KQVELAIKYG
LPVLVQDADE VDPILANILS KNIQTVAGRT FVILADKEID YDPQFRIYLT TKITNPMLDP
TLYAKAIVIN YMVTTVGLEN QLLSVVVKTE RPDIEEQRET LILETSKNKN LLQQLENSLL
REIAVDKGSM VDNIELIETL ENIKSSANEV MQKLVLAEIT SADINKLREN YRPVAERGAI
LFSVLADMAT VNAMYQYSLI SYIEVFIHSL KRSLPDPVVI KRLKSIIPML TKNVYDYGCT
GIFARHKLLF SLQTCMKIEQ NLGNVNQKQL EFFIKGSMIL EKVPKSNPTK WLSLSGWEDV
IKLASDFPEK FGQLPEEIRD SEDEWKKWYD SDTPESEELP CDYSTRVTSF EKLMLIRCFR
IDRIYRGITN YIIKIMGKQY ITPPQVSFDM IFEESTPTMP VVFILSPGSD PTSELMKLAD
RYGYGGGKFR YLSLGQNQEK IAMELLQTAK TRGQWLMFRN CHLLLSFTKN LEKIVENIEK
PHPDFRLWLT TEPTPNFPIG ILQQSLKVVT EPPSGLKLNL QNTYFNMRPQ VLESCSHPLY
KHLIYVLAFY HAVIQERRKY GKIGWNLKYD FNESDFNVCI TILDTYLTKA MATKESEVPW
NSLKYLIGEV MYGGRVMDNY DRRVSYTYMD EYFGDFLFDE HQPFHFYKDA IVDYVIPPEG
NRDDYLQFIE ELPLVNGPEI FGLHSNAEIG YFTQAVKGMW KHLIELQPQT DATVSVIGVS
KDEFIDNVAK EILTKIPVPY DISKVKRNFG VGVTPTAIVL FQELERFNKL IETITRTLNQ
LRKAIAGEIG MDAVLENISI ALYNGMLPKE WAKLAPDTRK NLAGWMDHFQ KRINQYTNWS
GANEPVVLWL SGLHVPETYL AALVQMACRK NNWPLDHSVI YTTVSKFFKP DDVEERPDEG
CYVYGLYLEG ARWDIEEHRL QRSHPKVLFE ALPILTIIPI EVHRLKLQNT FKTPVYTTSN
RRNTLGAGLV FEANLATPEH ISHWILQGVC LILNTD
//
