ID A0A158NMH6_ATTCE Unreviewed; 525 AA.
AC A0A158NMH6;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=105621904 {ECO:0000313|EnsemblMetazoa:XP_012058734.1};
OS Atta cephalotes (Leafcutter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Atta.
OX NCBI_TaxID=12957 {ECO:0000313|EnsemblMetazoa:XP_012058734.1, ECO:0000313|Proteomes:UP000005205};
RN [1] {ECO:0000313|Proteomes:UP000005205}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21347285; DOI=10.1371/journal.pgen.1002007;
RA Suen G., Teiling C., Li L., Holt C., Abouheif E., Bornberg-Bauer E.,
RA Bouffard P., Caldera E.J., Cash E., Cavanaugh A., Denas O., Elhaik E.,
RA Fave M.J., Gadau J., Gibson J.D., Graur D., Grubbs K.J., Hagen D.E.,
RA Harkins T.T., Helmkampf M., Hu H., Johnson B.R., Kim J., Marsh S.E.,
RA Moeller J.A., Munoz-Torres M.C., Murphy M.C., Naughton M.C., Nigam S.,
RA Overson R., Rajakumar R., Reese J.T., Scott J.J., Smith C.R., Tao S.,
RA Tsutsui N.D., Viljakainen L., Wissler L., Yandell M.D., Zimmer F.,
RA Taylor J., Slater S.C., Clifton S.W., Warren W.C., Elsik C.G., Smith C.D.,
RA Weinstock G.M., Gerardo N.M., Currie C.R.;
RT "The genome sequence of the leaf-cutter ant Atta cephalotes reveals
RT insights into its obligate symbiotic lifestyle.";
RL PLoS Genet. 7:e1002007-e1002007(2011).
RN [2] {ECO:0000313|EnsemblMetazoa:XP_012058734.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (APR-2016) to UniProtKB.
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DR EMBL; ADTU01002283; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADTU01002284; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012058734.1; XM_012203344.1.
DR AlphaFoldDB; A0A158NMH6; -.
DR STRING; 12957.A0A158NMH6; -.
DR EnsemblMetazoa; XM_012203344.1; XP_012058734.1; LOC105621904.
DR GeneID; 105621904; -.
DR KEGG; acep:105621904; -.
DR eggNOG; KOG4424; Eukaryota.
DR InParanoid; A0A158NMH6; -.
DR OrthoDB; 53554at2759; -.
DR Proteomes; UP000005205; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF275; LD03170P; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005205}.
FT DOMAIN 52..228
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 257..349
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 525 AA; 60996 MW; 9BBB8C44997689C8 CRC64;
MYSSLSPQTS LSSELRQIIN ERNMLSMRSR MKVLHALNED NEKCAEEKEK ILRSQAIQEI
LTTEVTYLQQ LEILAEFFIQ PILERKLLDH PLLVTLAENI KTLYNVSGEL VAGLKRNPDN
IAGVFHKLAP FFKLYSVYAY DYTQVLNLLQ TNEENDFVFK KFIYDQETRS EVGRKLSSLL
ITPVQRVPRY QLLVKQVLQH TPYRHREYRY LQACLVEIEK SAKHINTLIA QNEETQKLLN
LQKCIVTSIN LVKPGRILIK QGPLMRVSRR GNSTYKRYFV LLNDTLLYCK GEPETSLNIS
CVLPLNKCSL TCVLSKKLFR ITCLHETFLL YSENADSAEW IQSIQSAIKK YTECRQTLRK
ESSSRKPLRH KNINEFSSDG ISKKSIKRRR YIKDEQVSLD TSNIIYFKKD NEMDEDTQSN
NICLPLSIKR FKQNEYSKPG HTSPQVKNTK LKLCKNKNTQ SISTHRCLKK SSHSNYETLP
MTMTIHGISS CSITSNDEEH TSPFQIMSDF FTFIGITIKD FFTFK
//
