ID A0A158P0S7_ATTCE Unreviewed; 634 AA.
AC A0A158P0S7;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Kelch-like protein diablo {ECO:0000256|ARBA:ARBA00013699};
GN Name=105626698 {ECO:0000313|EnsemblMetazoa:XP_012063385.1};
OS Atta cephalotes (Leafcutter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Atta.
OX NCBI_TaxID=12957 {ECO:0000313|EnsemblMetazoa:XP_012063385.1, ECO:0000313|Proteomes:UP000005205};
RN [1] {ECO:0000313|Proteomes:UP000005205}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21347285; DOI=10.1371/journal.pgen.1002007;
RA Suen G., Teiling C., Li L., Holt C., Abouheif E., Bornberg-Bauer E.,
RA Bouffard P., Caldera E.J., Cash E., Cavanaugh A., Denas O., Elhaik E.,
RA Fave M.J., Gadau J., Gibson J.D., Graur D., Grubbs K.J., Hagen D.E.,
RA Harkins T.T., Helmkampf M., Hu H., Johnson B.R., Kim J., Marsh S.E.,
RA Moeller J.A., Munoz-Torres M.C., Murphy M.C., Naughton M.C., Nigam S.,
RA Overson R., Rajakumar R., Reese J.T., Scott J.J., Smith C.R., Tao S.,
RA Tsutsui N.D., Viljakainen L., Wissler L., Yandell M.D., Zimmer F.,
RA Taylor J., Slater S.C., Clifton S.W., Warren W.C., Elsik C.G., Smith C.D.,
RA Weinstock G.M., Gerardo N.M., Currie C.R.;
RT "The genome sequence of the leaf-cutter ant Atta cephalotes reveals
RT insights into its obligate symbiotic lifestyle.";
RL PLoS Genet. 7:e1002007-e1002007(2011).
RN [2] {ECO:0000313|EnsemblMetazoa:XP_012063385.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (APR-2016) to UniProtKB.
CC -!- FUNCTION: Probable substrate-specific adapter of an E3 ubiquitin-
CC protein ligase complex which mediates the ubiquitination and subsequent
CC proteasomal degradation of target proteins. May have a role in synapse
CC differentiation and growth. {ECO:0000256|ARBA:ARBA00043912}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; ADTU01005778; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012063385.1; XM_012207995.1.
DR AlphaFoldDB; A0A158P0S7; -.
DR STRING; 12957.A0A158P0S7; -.
DR EnsemblMetazoa; XM_012207995.1; XP_012063385.1; LOC105626698.
DR GeneID; 105626698; -.
DR KEGG; acep:105626698; -.
DR eggNOG; KOG4441; Eukaryota.
DR InParanoid; A0A158P0S7; -.
DR OrthoDB; 5472491at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000005205; Unassembled WGS sequence.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR24412:SF35; ACTIN-BINDING PROTEIN IPP; 1.
DR PANTHER; PTHR24412; KELCH PROTEIN; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 5.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF50965; Galactose oxidase, central domain; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Reference proteome {ECO:0000313|Proteomes:UP000005205};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 89..156
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
SQ SEQUENCE 634 AA; 71148 MW; 5E32597F59297F8F CRC64;
MRLKGKNNIK SFYRVLSRLC RFVDKGHLDG FMADGMAPAL KNGHNSDMDF ANQSVKQSSD
VSSVVYAVGH YPPKLLHNLN VQRRENKFSD VGLVAGDRII RAHRSVLAAG SAYFNAMFTV
GLVEEQQELV EIHSISPHIL SQLVDFIYSG NVDITQDNVQ ELFAAADMLE LDDVVAGCIN
YLKQQLHYSN ALGIYRFAEV HNRLDLLETA LRFIEANFPQ VCQEEEFLDL PKEHLVQFLS
SDYIHIDTEC QVFQAAYNWI VHDIPARRCY VFEILSHVRL RLCSLARLDR IILDCKDASL
IVALRSIQTD LVSNKGCLVP LHAQPRICAR KNILVIGGSK REHSADSWGR TAESTYESIE
KYDIFTGEWS EVAPISIGRI LPGVALLDGK VYVIGGELES CIIANCECYD PRDNVWTPIA
CMEEPRCDFG LCALDNSLYA FGGWVGEDIG GSIEIYDPIS NTWTLEGYLP EPRFSMGVVA
YEGLIYIVGG CTHNSRHRQD VLSYNPVTRE WNYLAPMLTP RSQMGITILD GYMYVVGGTS
KNQEVLTSVE RYSFEKNKWS AVAPMSMGRF YPAVAAADSQ LYVIGGDQSQ EINFYRTQIT
ISTVECYDPH TNKWHECASL PSSRGEATAI VTPF
//
