ID A0A158P3X5_ATTCE Unreviewed; 540 AA.
AC A0A158P3X5;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Mitochondrial-processing peptidase subunit alpha {ECO:0000256|ARBA:ARBA00016741};
DE AltName: Full=Alpha-MPP {ECO:0000256|ARBA:ARBA00030006};
DE AltName: Full=Inactive zinc metalloprotease alpha {ECO:0000256|ARBA:ARBA00032315};
GN Name=105627816 {ECO:0000313|EnsemblMetazoa:XP_012064483.1};
OS Atta cephalotes (Leafcutter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Atta.
OX NCBI_TaxID=12957 {ECO:0000313|EnsemblMetazoa:XP_012064483.1, ECO:0000313|Proteomes:UP000005205};
RN [1] {ECO:0000313|Proteomes:UP000005205}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21347285; DOI=10.1371/journal.pgen.1002007;
RA Suen G., Teiling C., Li L., Holt C., Abouheif E., Bornberg-Bauer E.,
RA Bouffard P., Caldera E.J., Cash E., Cavanaugh A., Denas O., Elhaik E.,
RA Fave M.J., Gadau J., Gibson J.D., Graur D., Grubbs K.J., Hagen D.E.,
RA Harkins T.T., Helmkampf M., Hu H., Johnson B.R., Kim J., Marsh S.E.,
RA Moeller J.A., Munoz-Torres M.C., Murphy M.C., Naughton M.C., Nigam S.,
RA Overson R., Rajakumar R., Reese J.T., Scott J.J., Smith C.R., Tao S.,
RA Tsutsui N.D., Viljakainen L., Wissler L., Yandell M.D., Zimmer F.,
RA Taylor J., Slater S.C., Clifton S.W., Warren W.C., Elsik C.G., Smith C.D.,
RA Weinstock G.M., Gerardo N.M., Currie C.R.;
RT "The genome sequence of the leaf-cutter ant Atta cephalotes reveals
RT insights into its obligate symbiotic lifestyle.";
RL PLoS Genet. 7:e1002007-e1002007(2011).
RN [2] {ECO:0000313|EnsemblMetazoa:XP_012064483.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (APR-2016) to UniProtKB.
CC -!- FUNCTION: Substrate recognition and binding subunit of the essential
CC mitochondrial processing protease (MPP), which cleaves the
CC mitochondrial sequence off newly imported precursors proteins.
CC {ECO:0000256|ARBA:ARBA00002123}.
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|RuleBase:RU004447}.
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DR EMBL; ADTU01008609; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012064483.1; XM_012209093.1.
DR AlphaFoldDB; A0A158P3X5; -.
DR STRING; 12957.A0A158P3X5; -.
DR EnsemblMetazoa; XM_012209093.1; XP_012064483.1; LOC105627816.
DR GeneID; 105627816; -.
DR KEGG; acep:105627816; -.
DR eggNOG; KOG2067; Eukaryota.
DR InParanoid; A0A158P3X5; -.
DR OrthoDB; 7099at2759; -.
DR Proteomes; UP000005205; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 2.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR PANTHER; PTHR11851; METALLOPROTEASE; 1.
DR PANTHER; PTHR11851:SF49; MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 2.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005205}.
FT DOMAIN 83..233
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 238..443
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 540 AA; 60230 MW; 230D748CC47FAF35 CRC64;
MLQRPLIVSL KKSSTRSKYL NTWQRCNFSS QRIPLDLKEN HKKTVTSFPP LTESIPNLPK
AVYSTAKEEH QITHITVLPN GLKVASENRF GQFCTIGVLI DSGPRYEVAY PNGISHFLEK
LAFGSTNSFD SKDKIMLALE KHGGICDCQA SRDTFVYAAS AERHGLDIVI QVLSDIVLRP
QITEEEVQIA KQTVHFELES LHTRPEQEPI LMDMIHSAAY KQNTLGLPKI CPEKNIEKIN
RKTLHTYLKH HYVPNRMVVA GVGIEHDDLV HAVTKYFVDQ KPIWEEQPDL IFSSNANSVD
MSIAQYTGGY VLEECNVPIY AGPSGLPELS HVVIGLEGCS HQDPDFVAMC VLNMMMGGGG
SFSAGGPGKG MYTRLYTNVL NRYHWLYSAT AYNHAYADTG LFCIHASCTP SHVKDMVEVI
VHEMVTMTSG VSDSELARAK KQLQSMLLMN LEQRPVVFED IGRQVLATGT RKRPEYFIQT
IDGISKDDIN RVARRLLKSA PCLAARGEVK AIPSMADIQN GLLDAQGRLP GSRSRLSLFR
//
