ID A0A158P4M0_TETUR Unreviewed; 3459 AA.
AC A0A158P4M0;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
OS Tetranychus urticae (Two-spotted spider mite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Trombidiformes; Prostigmata; Eleutherengona; Raphignathae;
OC Tetranychoidea; Tetranychidae; Tetranychus.
OX NCBI_TaxID=32264 {ECO:0000313|EnsemblMetazoa:tetur05g09505.1, ECO:0000313|Proteomes:UP000015104};
RN [1] {ECO:0000313|Proteomes:UP000015104}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=London {ECO:0000313|Proteomes:UP000015104};
RA Rombauts S.;
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:tetur05g09505.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (APR-2016) to UniProtKB.
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DR EMBL; CAEY01001580; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EnsemblMetazoa; tetur05g09505.1; tetur05g09505.1; tetur05g09505.
DR Proteomes; UP000015104; Unassembled WGS sequence.
DR GO; GO:0042575; C:DNA polymerase complex; IEA:UniProt.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 2.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041373; RT_RNaseH.
DR PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF17917; RT_RNaseH; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000015104};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transposable element {ECO:0000256|ARBA:ARBA00022464}.
FT DOMAIN 785..964
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 1395..1556
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT REGION 343..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1741..1769
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2148..2178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2198..2252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2284..2315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2360..2422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3164..3201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3223..3350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3362..3402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3415..3459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..358
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..389
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2198..2235
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2284..2313
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2365..2382
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2391..2419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3164..3199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3226..3242
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3243..3336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3362..3401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3432..3459
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3459 AA; 394293 MW; A3FD4350B1F21990 CRC64;
MQLRSGLHFN APEGVVIVRM LTPDQAVNHL AVWQVSIPAA PFALKRFYEC LRTHLMLYGD
TLEDNEIGEL PIDSVLNLEI PEWVIESRQN GLTEPEIQTI IRTLGRETEN IFRSAPNEIY
ALPIALGSIR RFIAVLNNHG VQIPVAPPPP PSIASSSPPV NIHNQGIDTQ SLAASLSILR
PDPPVVEFVK GEEMVEFIHK TKNKLAQENV DDTTRLRCFR KSLAHEILAI AENEVSDDIT
DYHTYVNALL NAIKTPVQQY SAAFQLKQLK YNLSEHPSTF IQKLRKAFAK AVGDYSPEIF
LHELMSHIPH FLTSEIYTLG YNGNLDQITT YLIRKHFEYL QQQQSHKSRS DKNDKSNFHP
KVSTVSSMLK KPDSRNNSKP YPKPTSQHNT HIVCNYCKKP GHTINQCRTR PQNNRPYNSN
RNSNPSTSNS NQNQASSSSQ PLAITNTPAN ASNLTIGSNQ LPPEPTQDGF RDSRISYSLQ
TVQPVQPIPM LTNLGESKLS HMPTAVFKLC RPNKEIVREG KVLLDTGSAI SALDSSIAEE
LGAHIIPYSR SLKGIAAQTY VPSHGIAYAV VKHPKMAESR VFRLQIVNNF EPVCLIGNAF
LHLYYMQLKS DGNDYITTCS EYLDSTPLDP NFYFRFCTPE ETQQILNSTL YPTGNDSDSY
ILDTRTKRSA NPVSLQVGNS PAIIAKCDLH SPQEIIEIQR QERPFKTKIY EKIDENLPDN
LKQQLADLID SFQDTFAKSK NDLGLVPSSV CPIAIDLDGQ VPETLPYNCP IHRRNEFKKI
IDEMIANDII EESNAPGGSP AILVPKPDKS YRMVIDYRKL NRLTRVPRHP MPRIDDCLEV
VRNGKYFNIF DLAQGYHQIE LPPDERVKTV FVTPDGKYHY KRLPMGLAAA PFIFQKLMNK
VLEGLIYQKC IGYFDDIPVV GKDFPDLLSN TELILTRLRQ YNLKVKLDKC QLGYTEILLL
GHLVSGQGIR PDPKKVEALK NLPYPRNVRE LQSILGCYNY FSRYIPNYST LAAPLYRLIS
KEKRFRIMPE DKKALDTLKN SLISTTLLVH YDPKLRRKIA ADASDHAVGG ILQQEDSNSS
SYNPNTPIEE VKDWLPLSFY SQKLQKHQKH YSVSEKELLA IFVGINKFNH FLEGEQFLIE
TDHHALCQLT KVNFKNSRLQ RWSIMLSTYD FKVVYKQGST HPPDCFSRYQ SAWSHRKIID
PEEEFLDRIY LIDYFLDPFE NRLYDIGMNQ ICAIESDHLD DFTLPPSLCY STSTEVAHIK
NSVKPSNSEF SIWKEKVRET QTNNPNIQNI IKLYKANDSV TLKRYVIKDG LLYRKDVNTP
FGSRLVIDAK LLKDLFSYEH ESPLGGHFGP EKTYFQIARR FWCQYLYDLV KQLCDSCTIC
QISKPTNVIY VDPSTKPIPN EIFERLELDA QGPIVINQVK KYIIVLVDIL SRYVFAKLTT
NQTAQTVISL LTSLFQTFGF PKVIQTDQGT NFTSEAVHQF LKENGIKHEK SNPYHPQSQG
IVERCNRTIA ERLRSYVLQN GTKNLKNALE ASVFAINTSI HKITRFSPYF LVFGRHPRKP
IDNLLEFPDS FSFDVNQARK LAYARLHSQQ IYQINRTKAL HQSSPYREGD FVYVKNESLD
PKISKKLREK YHGPYLVCGI QKGSLLLLEL EDLGLFSCNV SNTKLYRGEL TEKMKKLKDQ
YFNPDTFLEN ENFNIPNTPS FIDSVINNPI DHLSDIQELS AEENQDDQDD QTNSVQNETI
NAQKSDSNES NFPSLPSDNS TNNSIPSPPL IITKTPYNLN KFLKFNFEKP LTNSFPNSIH
TENNDGSNHL PNLNQKELEN STELTNSEPK LSQMQTIPKG ILIQNQNLNN LDSNSSLIPD
SSDYIQNQFQ DKNMKKPRKK YITADRAISL QNPISISEKR LTRNQSKIAK NLPSNTYVLY
YCLNLDYTEI RKIESNKSST FDKAYAFSAN RVEAYPQGES KIKSESKSEK DPFTPSLETK
EKFSLQNRWL TINRNLLIAP SLDLVFTPLN PYHFTLSFLV KTFDFKSLSN FLNSQEFSSN
YFYHSSDFNF NFNFISLFQF NSKSNSTFNL ISFNSKFLTN SLEFSRRPFQ FLNLVIFSSS
SNFQSSIPSV FLSKFLNFSS LPHSIMQPNK QIVKQRVLRS TLIERILPSG ETERVPTPPR
PIQSPSPSPQ QSSSSNVDAH LVPSLETDDS TVVIMVPRSE QSENSDSGAS KVPKSSGAVR
TIRQVSGVPH PSSPPTLNAS MLPPPLPKNK KFNQNNFQFE DLVESDSETD DETKAFRVAQ
RISMNQKDGS SSSGAAQSSS QVPSHQVAIK RPSNNNYPAM KRLYLAPPLQ LRNRLHPIQM
QKLPEISNLR PFRNIYPKPP LSIKAPSMTN PNSNSNSEHE NTVHWGDPMV QVHNYTQSNS
SNNSQNSDNP QQSKQNAPKI NLHPKLYIKE GKKFPEKYLK PSEYDFKPKE YPAPLPTAPL
PDYLTDERFY EVKNLVQTKA KAFSDLKAKF EIMIREKLYL NLYDDENLKT MPLKAIPHGI
TKAQIKNLEL KDIEKSIRCY FCEQISIDPK ECRSCKNWYC SLCIEWLRDL VSTLNLFPLF
HPHQFLCLLP ECVQHFASKD DYPFFQPTSS KQLTDSYNQL LFTCRRTCCS ESFPPNAILE
HERKCRLGLF LEEFDFNIDL PFVSTEVREE LVKAPKRLAN FLPTHLKTGQ AKPPPNQNNH
ENRWYDRFNL WACLSNLKDS DPSDPLLNPI AIRSLANVGL SFWNNYKRIQ DPTTPLDETE
DFIQNVVGLE PSIGKRVPSS VPQRPHTIFW SRVPFYLIND SEEWLRIAVG LAPKYVPRYN
KDFAPESNEQ PIGPFVRIDP LERIPEQLRD EVVQSAKYLF PTSFKGFQSA RDNTPATDNI
QYRQNRQNKA HAQFQEFNRL TVINMPRLRP STEKLIQDAI ELHPSPSTTY SIHMAYCRIK
YMVEPLRVLA RPRPVWVVIV DGYKNIVFES FVSYPHHIDY MDSHFHGLTQ RDIKYAKNFE
SVRNQILEFF VTATSIVGSG LINLLRSLDL TDQEIANLKP KLLDMTQYFS PYRGVPASLA
LSSFLLFPKF VIKPDPHSPA LEAITAMNMY LAFWEPIEEM ARIHGGIHFG NIPQTCGNPH
MARLFQLYDE RVRQGLAEWP TDWTHHVRRG EPRFNQRCVS PATQPQANYY DSSSSNSRAT
SPTSSNASST NQSGKPCTQS HPVPLAIEAI PEEIPLIDLE PEEQNQMPPP LIPNPLNPSS
PHNTPPQQIS RRNSAASDRS NQSNRSNHSN HSRNSNRSKH SQQSNRSNHS QQSQHSNHSI
RSNTSNRSLP ARLQPSYFNQ NRPRSNSTSS HQASLPQFPP PRIEFPDSDS SSTIYSFLKE
SDKSVDSGSS LSSQSSASSI SDHATSTASS SSSTSSLNSR RDEQLQRIRQ MIADLPPPFG
IIHPPMQSPP ESQRRTPSGS PYSTSSSNSY HLCSDYQDY
//
