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Database: UniProt
Entry: A0A158P902_ANGCA
LinkDB: A0A158P902_ANGCA
Original site: A0A158P902_ANGCA 
ID   A0A158P902_ANGCA        Unreviewed;      4798 AA.
AC   A0A158P902;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   10-MAY-2017, entry version 9.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|WBParaSite:ACAC_0000767301-mRNA-1};
OS   Angiostrongylus cantonensis (Rat lungworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Strongylida; Metastrongyloidea; Angiostrongylidae; Angiostrongylus.
OX   NCBI_TaxID=6313 {ECO:0000313|WBParaSite:ACAC_0000767301-mRNA-1};
RN   [1] {ECO:0000313|Proteomes:UP000035642, ECO:0000313|WBParaSite:ACAC_0000767301-mRNA-1}
RP   NUCLEOTIDE SEQUENCE.
RA   Suarez D.L., Cauthen A.N.;
RL   Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:ACAC_0000767301-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   WBParaSite; ACAC_0000767301-mRNA-1; ACAC_0000767301-mRNA-1; ACAC_0000767301.
DR   Proteomes; UP000035642; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 3.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 2.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00472; MIR; 3.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 3.
DR   PROSITE; PS50919; MIR; 3.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Complete proteome {ECO:0000313|Proteomes:UP000035642};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035642};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4197   4216       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4361   4378       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4423   4445       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4561   4583       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4595   4621       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4681   4700       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      102    156       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      163    207       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      296    354       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      393    410       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN      502    713       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1310   1523       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3960   3995       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN     3998   4030       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    3973   3984       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND    4008   4019       {ECO:0000256|PROSITE-ProRule:PRU00448}.
SQ   SEQUENCE   4798 AA;  546378 MW;  781ACC13CB747FBD CRC64;
     MDHDSIAELH EDYHYVNKGD IVCLSCVASH NRDGVLGSER VCLCTEGFGN RMCTLENVSD
     RDTPPDIAIC MLYIDNALSM RALQEMMSAD SEHKSASGAG GHKTLLYGHA VQLKHVQSEM
     YLACLSSCSS NDKLAFDVGV QETNTGEACW WTIHPASKQR SEGEKVRVGD DVILVSVATE
     RYLHMAHSKG YMVIASFHQT LWNIQSVSSG SVRTRNMGYV FGNDVMRLFH GNDECLTIPE
     NWSEHPQHKY LGVLDNAVQL YHKDKADFDL TAFVMCQNKD PRKQILDEKE DEGMGTATIR
     YGETNAFIQH VKTQLWMSYQ TSEVTKKGLG KVEEKKAVAL KDGHMDDCYT FFMALEEESK
     SARVIRKCSS VLNRFLKGIE ALQNEGNQSV DWGRVDLNEV LKLMEDLIEY FSQPADDQDF
     EEKQNRFRAL RSRQDLFQEE GVLNMILDTI DKFSQMEALP DFAGIIGEDT HEITTTVLNS
     LLLNVLTGIL DVLYCVLTES PEALNMINEC HIRSVISLLE KVGRDPKVLD VLSSLCEGNG
     MAVRSSQNLI TEYLLPGKDL LLQTAMRDHV SSMMPNVLVG VVEASALFRR WYFEAEEPYL
     RVGWANSSGF KPFPGSGDRW GCSGVGDDFY SYGFDGRCVY FAGRGRVVSP RLLEKGDVVG
     CSLDLTVPEI RFSVNGHDVG ASYKDFNVDG YFFPVMSLSA KVSCRFIFGG DQGRLRFGPP
     PGFSATVEAV SGELQITDCL SFGDLPKNVY CGPHTLFTST EPFVPQPVDI SDTILPHLIN
     DIHPRFAENL HELWAMRKIE LGWSYGETRS ETLRKHPCLT SFDRLPATEK QYNINLALDT
     LKTIEALGYH LITDEPPTRL RPVRLAQNFQ QSNGYRPHPL DTHEITLPDE LNPLVEALAK
     NTHNVWAREK IKRGWTFGFS EFVDSTQKRS PHLVPYEEVD NRIKEANRES AAENLRALQL
     FGVFIEAPAH EHDEMAEKEM RARRDHTRTY RAEATYAVTG GKWYFEFEIL TAGLMRIGWM
     DVGASPAVQL GYDDRGYAFD GYLGRKWHQG AEDPSGSEMA FDNVLCGDGL VPAMSLGSGQ
     KGRLNFGQQS NSLKFFTTCG LQEGYEPFCV NMYRAMPMWF AKQLARFEDI SAGSLLELSR
     IPATGNSPPC LKLTQKKTET FRDKDAIRRL LTEFKPRNQS VVSQIRAPTI PQEFQDTKER
     KQPLSALRGV KSSRESDEVT SNRSKQPSYD GDHDSEQLAL RGSLNDFSQV DRHNAEEHLK
     EITDREKPPK KSGGLLSRFR DSSGSRRKDG KGKDEKSARL VGPKTKWRSV DASSVDASDG
     TPTGQKDILA ATDMPSSGPG RQLTEAVVPM EKRGSQAPID ITPDAQHELD IDAMAQHGDK
     VDEYYYGIRI FPGQDPSQVW VGWVTTQYHF YSSSFERENV ERRCVFVEGN QQSNTENVEY
     RNSYMMNAAE LLSHVPDATN TKVSGTLIGC IVDTSVGELS FQAAGQDTGV KFKLEPGAML
     FPAAFFTPTT AEILQFELGR IKYTYPISAA MFKSCEKSLI SFCPPRLTVQ CIEPVYWARV
     PNESLRTTAL KLSDIRGWSV LCDDPVRIMT IYVPEKDESF DILEMIEKPI FLDFHRQTLN
     LYCKLASHGN QKVAHILCRH VDEDQIMYAV KNLSGPMRQG YHDLLIAIHL QTHASARQSM
     SKEYVIPLCD QLHNQNVFDP DSENRYPQIM GETYSMLPVM VAEPVRTNFT QEEEMKLLPP
     AVNFDALKAH VMSAMESATR HAVMNCRDLI GGNNRNHFEP LLKLFDSLLV IGLFDDLELE
     AILNLIHPTA FSPAYVPASA QKGLTEIELD EHVKIQIVNI IDHLCDIQLR HRIESLIGFT
     DGFVGELQRD QCKRYMEIKQ TDMPPAEAAK KTKEFRCPPK EQMDFCSMLV AKLGNESDYE
     DEESQNLIKV EEGSWVDALA RLVVAVPPPP PSNDKELNMK KGTRNFRDMI VNMLREWALG
     DFIESNELIR KMFNLLLRQY SGVRELQDAM AQTYVLHERN NEDVQDFIVY LIQIRELLTV
     QFEHIEEAIL KRGLWKLMNN RIFFQHPDLM RLLSVHENVM TIMMNILTAQ QGAVEHEGEE
     VKEKIPVKDS SEMVVACSRF LCYFCRTSRQ NQKAMFEHLS FLLDNATMLL ARPSLRGSVP
     LDVAYSSFMD NNELALALKE EELDKVTVYL SRCGLQPNSE MISKGYPDIG WDPVEGERYI
     DFLRFCVWIN GENVEENANL VIRLLIRRPE CLGIALKGEG QGLFAAFKEA IALSEDIRTL
     EEDITGSPSL RSGLLGETPS YPSKETESED YLDLGAATLD FYSSLVDLLA KCAPDHIAIQ
     AGKGDSLRAR AILRSLISLD DLGQILSLRF TIPNLTLATT DDNGPLPGLL PNHKGSVLLF
     LDRVYGIDSQ DMLFHFLEQS FLPDLRAATM MDSPRALESD TALALNRYLC NAVLPLLTNH
     SHFFADAEHH TALLDATVHT VYRMNRLKSL TKNQREAVSD FLVAITRELP PGMMIKLLRK
     VIADVQQMSD MNVLVPLRLM TLHYERCGKY YGTGNQYGVA TEVEKRLSML LFYAIFDSLG
     SRPYDPDLFG KALPCMTAIG SAISPDYTLT TSGEDAPKLK EKLDDGAWVP KQVEVSYSDL
     PKDLQTMTEK FAEHFHDSWA SRKLEKGWVY GDLYSRQNCT HPRLKPFSLL RDFEKNFYKE
     RCAECLRALI DWGYTFELRD PDVAERAVNA HTPSGTSVQN FSPKPVDLTS MTLEKDMVAA
     GEKMAEWSHL IWASKVWNDL NTKGGFMPTS LVPWDLLTDF ERRKDRFRAN EILKFLQYHG
     YHVESPKIES NLERGKNEGE RSSVEKRFAY NLLEKLIQYL EQASLKMKSV KPSQELTRRN
     TFRKEGQDVK FFEKVVLPLM HAYFNAHKNY FLEGSSMVQT GTASNKEKEM VANLFCRLAA
     LLRIKNRAFG SVAKITVKCL QGLTQALDLR TLVKTNSDIV RTSLLTFFNN CADDLFVAVN
     ELKDNGQYSL LRGQNLKSWI SLEFAHQMIV PVLTSMFTHL ARNHFGTDLL LDDIQAACYK
     ILNSLYMVTG LSATAAQRKS IGYETEKHRP GLGQCLSAFA SCFPVAFLES EYNKNNKYSV
     LAKTQDQSVQ VQEMLQNLNT HIPHIEKLLT DIETVSTTGV MYNDNPNIYD VDLPLMCSYL
     AYWFNQGPDG RKSEKLEEHR HSLPMTAVSA EHINRIFCAL LRMLRNHIVF AVQIIQNVTC
     DPVKDHILPI AERLRRMSEK AFREEEHMRT HPDDADEGTV AEDNARLVRD TYAYFPILMK
     YTDLHRAQWL KTPSWETDGV YENVAVIFRI WSQSQHFKRE ELNYMAQFEE DAAMFGGGEM
     KTGKAAIAER KKKRREGQVK KDKHASSIVI ACLKRLLPVG LNLDIVQQSK ERFLQKEPEE
     KVREFIKGLL DVQVKTDPTD KNAWQLSLYR KIGKSQMRGK NEMTQDAVIE KIFNMGQVSA
     ILHTTEHPQQ QLTQAWKKIV STQRKRAMTS RLEREDKWKR VLTLQRKRMA ISLITASHLY
     RVDRHRGINF FLPAFSRLWL EEEDVGQDKL ITDLVSGVVT EDNTRVEVVL EDGVPVQEES
     RESDSHPDPL KQLIRCFQRA ATSEQSLATP IHDDNLYIRF ADVMSKSIHI EEEDGDDGDD
     EVDQAQKEEQ SQALRAEQGV LADRGAAIMC LMYLSASNGE PNDMVARTLE LGIHLLSGGN
     VEIQRMLIEY LQLKKDVRFF TSMAGLMNKC SVLNLEMFER QIKAEGLGMG ADLAAGANQN
     LNDAEFTCSL FRFLQLTCEG HNLDFQNYLR TQPGHTTSVN LINCTVDYLL RLQESVMDFY
     WHYSSKEVID EGGKEYFLRA IQGPCVGNQM TLANSRLWDA INGFFFLFAH MMEKLYRNST
     QLELLREFLN LQKDMIVLML SMLEGNVLNG PIGKQMVDAL VESQPSVEKI IKFSDMFLKL
     KDLTTSQAFL DFDTNRDGWI SPKEFQRAME SQKMYTVEDI TYLMMCTDVN NDGKVDYMEF
     TERFHNPARD IGFNLAVLLT NLKEHITNDP RLEKIIEKAH TLLEYFDPFL GRIEIMGSSK
     RVEKIYFEIQ ESWLEQWGKQ QIRDSKNSFL FNVLQDDGGD QGKLEAFINF CEQSSAGEQL
     SQTFKSGYIY GLTAASALRP ENVKQTFKDV SAKVRQMTWI QLFCAIGLLL FHCLKKLGYT
     VYLILMTLFR FVYYLTTPGK DEDEAKTPLK ETHFQHYGLP ILPEFHHTHI GVEAFGFAAE
     QLPTEHHLYQ DIPTFITEEV KSEQPTPQKP PSNDSPSPPS VHKAPSMYES VGAPAPMVAS
     PSEMDLHVGS YEPKIAEQNI SRSKGSILNM LARNFKTIEK TTLYLAFFIN VILLFHRVDI
     KRTEPVEDAH EDDEEKTAES IYISGMMLPY IEYELTGWVL AQVLYWISVL HLSTSFALLV
     SFYQLKIPLI TFKREKEVAR RLMFDGCWIT EEDNEESGVI DTLLWYLDRI VISSKSFPMM
     YWDKFVRRKT RQKFKDQVDE ETLTAILGEE KSSSDNSFDY RYTCWLWIGV ILTNGQFLYR
     VGYLLCSACG VFISPFFYAF HLIDVVLSFP MLKAILQSLI LTIMMTLVVV YLYTVIAFNF
     FRKFYVQEGE DGEEPDRKCH NMATCFIYHF YVGVRAGGGI GDELESPYGD ELEYPRMFYD
     ISFFFFVIII LLAIMQGLII DAFGELRDQQ ESATEKLESS CFICDIGKET FDRMPRGFEI
     HTTKEHNFAN YLFFLQHLVN KDNTEYTGQE TYVREKDWDF FPVGECFVKQ YEDQLLQS
//
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