ID A0A158PD32_ANGCS Unreviewed; 696 AA.
AC A0A158PD32;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=adenylate cyclase {ECO:0000256|ARBA:ARBA00012201};
DE EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
GN ORFNames=ACOC_LOCUS209 {ECO:0000313|EMBL:VDM51794.1};
OS Angiostrongylus costaricensis (Nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC Metastrongyloidea; Angiostrongylidae; Angiostrongylus.
OX NCBI_TaxID=334426 {ECO:0000313|Proteomes:UP000050601, ECO:0000313|WBParaSite:ACOC_0000020801-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:ACOC_0000020801-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDM51794.1, ECO:0000313|Proteomes:UP000267027}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Costa Rica {ECO:0000313|EMBL:VDM51794.1,
RC ECO:0000313|Proteomes:UP000267027};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001593};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001436};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; UYYA01000017; VDM51794.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A158PD32; -.
DR STRING; 334426.A0A158PD32; -.
DR WBParaSite; ACOC_0000020801-mRNA-1; ACOC_0000020801-mRNA-1; ACOC_0000020801.
DR OMA; TPWTIGE; -.
DR Proteomes; UP000050601; Unplaced.
DR Proteomes; UP000267027; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45627; ADENYLATE CYCLASE TYPE 1; 1.
DR PANTHER; PTHR45627:SF29; ADENYLYL CYCLASE; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000267027};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 91..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 118..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 159..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 190..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 327..455
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 602..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 696 AA; 79858 MW; 12D33C75CE6AE86F CRC64;
MIIVIYRRSL SLNYYCYHYS RCYYYHYYRR FSMVTVPQGI NRLLQTLSTI DPQIKSIGNT
KKSKCSLMNS VSLRFKNSRL EDEFHKEMDH WFIPALAISI FFLVVYGIYH MLVMPRLLTS
LALIIVALTL MFFILLTLYI NYFHSFTQFI TRTSHGHSLA ILLIIAILFL CGIVNTFSCP
QPEEADICQT IHFSAFSFAM WILTTAVFIR FSSIYLLAVL TFAIFIYTIQ IFLTHPPIGP
KEFTIEFDLW VGLSSLAALV FLHSRRCEKI MRLDFLSVVK GVEESASKDR FVLLNSQVLL
NLVPPHVAPW VAAKTGEQWH HAHHSVGVAY LTISGFSLSD EQGLNGLNYV FTSFDQQLTN
FRGIEKIKSA NRFYIVAVGL LPDAAQNVNE TPWTIGELLH TLAQFLLQAT QFATEKEFQV
QIGMDCGSAL SLVTDTDQPR YELWGETVER ARILMQSASH GRTLVSEEIF LALRPRNLHF
STKSIKVRHS HILGKDAKKD EFHILRLSRL WRTCFTYSKI GNSTDYDDSL ADPAERLEAA
AHRVDRMLQE LNAYGEFTDI KPLEYRPFPT AFGSLKSVHR ALSSACHTEY DNAESEAALS
DVEMNANGRM SSRRRRHRSR RSEDVNVETE CSSLSSSIEL DPLRWNSAHS IGYENEYEMQ
SDNEGLAIDE MKVLSRDIRR HFGDFNLTTF DDMHPD
//