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Database: UniProt
Entry: A0A158PDE3_ANGCS
LinkDB: A0A158PDE3_ANGCS
Original site: A0A158PDE3_ANGCS 
ID   A0A158PDE3_ANGCS        Unreviewed;      4328 AA.
AC   A0A158PDE3;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   10-MAY-2017, entry version 9.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|WBParaSite:ACOC_0000057401-mRNA-1};
OS   Angiostrongylus costaricensis (Nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Strongylida; Metastrongyloidea; Angiostrongylidae; Angiostrongylus.
OX   NCBI_TaxID=334426 {ECO:0000313|WBParaSite:ACOC_0000057401-mRNA-1};
RN   [1] {ECO:0000313|Proteomes:UP000050601, ECO:0000313|WBParaSite:ACOC_0000057401-mRNA-1}
RP   NUCLEOTIDE SEQUENCE.
RG   Helminth Genomes Consortium;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:ACOC_0000057401-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   WBParaSite; ACOC_0000057401-mRNA-1; ACOC_0000057401-mRNA-1; ACOC_0000057401.
DR   Proteomes; UP000050601; Genome assembly.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00472; MIR; 3.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 3.
DR   PROSITE; PS50919; MIR; 3.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Complete proteome {ECO:0000313|Proteomes:UP000050601};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050601}.
FT   DOMAIN      122    176       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      183    227       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      316    374       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      417    434       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN      558    779       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      992   1197       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1439   1662       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4117   4152       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN     4155   4187       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    4130   4141       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND    4165   4176       {ECO:0000256|PROSITE-ProRule:PRU00448}.
SQ   SEQUENCE   4328 AA;  491506 MW;  A2B4A1495306AB93 CRC64;
     MLYSDTIDSG EGFGRKRREE KRRENYPVEA FSFLLRFQGD IVCLSCVASH NRDGVLGSER
     VCLCTEGFGN RMCTLENVSD RDTPPDIAMC MLYIDNALSM RALQEMMSAD SEHKSTSGAG
     GHKTLLYGHA VQLKHVQSEM YLACLSSCSS NDKLAFDVGV QETNTGEACW WTIHPASKQR
     SEGEKVRVGD DVILVSVATE RYLHMAHSKG YMVIASFHQT LWNIQSVSSG SVRTRNMGYV
     FGNDVMRLFH GNDECLTIPE NWSEHPQHKY LGVLDNAVQL YHKDKADFDL TAFVMCQNKD
     PRKQILDEKE DEGMGTATIQ YGETNAFIQH VKTQLWMSYQ TSEVTKKGLG KVEEKKAVAL
     KDGHMDDCYT FFMALEEESK SARVIRKSGH VNILEMPINF RGIEALQNEG SQSTDWGRVD
     LNEVLKLMED LIEYFSQPAD DQDFEEKQNR FRALRSRQDL FQEEGVLNMI LDTIDKFSQM
     EALPDFAGII GEDTHMMWEE IATYLYLLVA AMIKGNHYNC AQFAAAQRLD WLFGRLSNPQ
     SAEGILDVLY CVLTESPEAL NMINECHIRS VISLLEKVGR DPKVLDVLSS LCEGNGMAVR
     SSQNLITEYL LPGKDLLLQT AMRDHVSSMM PNVLVGVVEA SALFRRWYFE AEVEHIEQMT
     KEAPYLRVGW ANSSGFKPFP GSGDRWGCNG VGDDFYSYGF DGRCVYFAGR GRVVSPRLLE
     KGDVVGCSLD LTVPEIRFSV NGRDVGASYK DFNVDGYFFP VMSLSAKVSC RFIFGGDQGR
     LRFGPPPRFS ATVEAVSGEL QITDCLSFGE LPKNVYCGPH TLFTSTEPFV PQAVDISDTI
     LPHLIDDIHP RFAENLHELW AMRKIELGWS YGETRSETLR KHPCLTSFDR LPTTEKQYNI
     NLALDTLKTI EALGYHLITD EPPTRLRPVR LAQNFQQSNG YRPQPLDTHE ITLPDELNPL
     VEALAKNTHN VWAREKIKRG WTFGLSEFVD STQKRSPHLV PYEEVDNRIK EANRESAAEN
     LRALQLFGVF IEAPAHEHDE MAEKEMRARR DHTRTYRAEA TYAVTGGKWY FEFEILTAGL
     MRIGWMDVGA SPAVQLGHDD RGYAFDGGGT SNFSYLGRKW HQGAEVYGRE WKIGDVVGCF
     LDLNDRTISF SLNGELLLDP SGSEMAFDNV SCGDGLVPAM SLGSGQKGRL NFGQQSNSLK
     FFTTCGLQEG YEPFCVNMYR AMPMWFAKQL ARFEDISAGS LLEISRIPAT GNSPPCLKLT
     QKVGCSKMKT FRDKDAIRKL LTEFKPRNQS VVSQIRAPTI PQEFQDTKER KKQPLSALLG
     VKSSRESDEV TSNRSKQPSY DGDHDNEQLA LRGSLNDFSQ EDRHNAEEHL KEIADREKPP
     KKGGGLLSRL RDSSGSRRKD GKGKDEKSTR LVGPKTKWRS VDTSSVDASD SIPTGQKDVL
     AANDMPSSGP GRQLTVRRSS MKKKKKKEPV VSMEKRGSQV PIDITPDAQH ELDIDAMAQH
     GDKVDEYYYG IRIFPGQDPS QVWVGWVTTQ YHFYSPSFEK ENVERRCVFV EGNQQRNTEK
     SVFLELPIHY LLHLIIVEYR NSYMMNAAEL LSHVPDATNT KVSGTLIGCI VDTSVGELSF
     QAAGQDTGVK FKLEPGAMLF PAAFFTPTTT EILQFELGRI KYTYPISAAM FKSCEKSLVS
     FCPPRLTVQC IEPVYWARVP NESLRTTALK LSDIRGWSVL CDDPVRIMTI YVPEKDESFD
     ILEMIEKPIF LDFHRQTLNL YCKLASHGNQ KVAHILCRHV DEDQIMYAVK SHYLSGPMRQ
     GYHDLLIAIH LQTHASARQS MSKEYVIPLC DQLRNQNVFD PDSENRYPQI MGETYSMLPV
     MVAEPVRTNF TQEEEMKLLP PAVNFDALKA HVMNAMESAT RHAVMNCRDL IGGNNRNHFE
     PLLKLFDSLL VIGLFEDSEL EAILNLIHPS AFSPVYVPAS AQKSLTEIEL DEHVKIQIVN
     IIDHLCDIQL RHRIESLIGF TDGFVGELQH DQCKRDFCAM LVAKVGNEGD YDDEESQNLI
     KAEEGSWVDA LARLVVAVPP PPPSNDKELN MKKGTRNFRD MIVNMLREWA LGDFIESNEL
     IRKMFNLLLR QYSGVRELQD AMAQTYVLHE RNNEDVQDFI VYLIQIRELL TVQFEHIEEA
     ILKRGLWKLM NNRIFFQHPD LMRLLSVHEN VMTIMMNILT AQQGAVEHEG EEVKEKIPVK
     DSSEMVVACS RFLCYFCRTS RQNQKAMFEH LSFLLDNATM LLARPSLRGS VPLDVAYSSF
     MDNNELALAL KEEELDKVTV YLSRCGLQPN SEMISKGYPD IGWDPVEGER YIDFLRFCVW
     INGENVEENA NLVIRLLIRR PECLGIALKG EGQGLFAAFK ASDFFLVPPY NEETANNKDL
     VEAIALSEDI RTLEEDVTGS PSLRSGLLGE TPSYPSKEAE SEDYLDLGAA TLDFYSSLVD
     LLAKCAPDHM AIQAGKGDSL RARAILRSLI SLDDLGQILS LRFTIPNLTL ATTDDNGPLP
     GLLPNHKGSV LLFLDRVYGI DSQDMLFHFL EQSFLPDLRA ATMMDSPRAL ESDTALALNR
     YLCNAVLPLL TSHSHFFADA EHHTALLDAT VHTVYRMNRL KSLTKNQREA VSDFLVAITR
     ELPPGMMIKL LRKVIADVQQ MSDMNVLVPL RLMTLHYERC GKYYGSGNQY GVATEVEKRL
     SMLLFYAIFD SLGSRPYDPD LFGKALPCMT AIGSAISPDY TLTTSGEDAP KLKEQLDDGA
     WVPKQVEVSC NDLPRDLQTM TEKFAEHFHD SWASRKLEKG WVYGDLYSRQ NSTHPRLKPF
     SLLRDFEKNF YKERCAECLR ALHDWGYTFE LKDRDAAERA ANAHTPSGTS VQNFAPKPVD
     LTSMTLEKDM VAAGEKMAER SHLIWASKVW NDLNTKGGFM PTSLVPWDLL TDFERRKDRF
     RANEILKFLQ YHGYHVESNE DLCNTMNCSP KTESNLERGK NEGERSSVEK RFAYNLLEKL
     IQYLEQASLK MKSVKPSQEL TRRSTFRKEG QDVKFFEKVV LPLMHAYFNA HKNYFLEGSS
     MVQTGTASNK EKEMVANLFC RLAALLRIKN RAFGSVAKIT VKCLQGLTQA LDLRTLVKTN
     SDIVRTSLLT FFNNCADDLF AAVKELKARL KMEPLFDNGQ YSLLRGQNLK SWISLEFAHQ
     MIVPVLTSMF THLARNHFGT DLLLDDIQAA CYKILNSLYM VTGLSATAAQ RKSIGYETEK
     YAWFIFCVFV VSVLKHRPGL GQCLSAFASC FPVAFLESEY NKNNKYSVLA KTQDQSVQVQ
     EMLQNLNTHI PHIEKLLTDI ETVSTTGVMY NDNPNIYDVD LPLLCSYLAY WFNQGPDGRK
     SEKLEEHRHS LQMTAVSAEH INRIFCALLR MLRNHIGVES APWLCRTTFF AVQIIQNVTC
     DPVKDHILPI AERLRRMSEK AFREEEHMRT HPDDADEGTV AEDNARLVRD TYAYFPILMK
     YTDLHRAQWL KTPSWETDGV YENVAVIFRI WSQSQHFKRE ELNYIAQFEE DAAMFGGGEM
     KTGKAAIAER KKKRREGQVK KDKHANSIVI ACLKRLLPVG LNVFGGRLVD NFFPFLELDI
     VQQSKERFLQ KEPEDKVREF IKGLLDVQVK TDPTDKNAWQ LSLYRKIGKS QMRGKNEMTQ
     DAVIEKIFNM GQVSAILHTV RTEHPQQQLT QAWKKVVSTQ RKRAVVACFR MVPLYGIPRH
     RGINFFLPAF SRLWLEEEDV GQDKLITDLV SGVVTEDSTR LEVVVEDGVP VQEESRESDY
     IRFADVMSKS IHIEEEDGDD GDDEVDQAQK EEQSQALRAE QGVLADRGAA IMCLMYLSAS
     NGEPNDMVAR TLELGIHLLS GGNVDIQRML IEYLQLKKDV RFFTSMAGLM NKCSVLNLEM
     FERQIKAEGL GMGADLAAGA NQNLNDAEFT CSLFRFLQLT CEGHNLDFQN YLRTQSGHTT
     SVNLINCTVD YLLRLQESVM DFYWHYSSKE VIDEGGKEYF LRAIQVCSQV FNTLTESIQG
     PCVGNQMTLA NSRLWDAING FFFLFAHMME KLYRNSTQLE LLREFLNLQK DMIVLMLSML
     EGNVLNGPIG KQMVDALVES QPSVEKIIKF SDMFLKLKDL TTSQAFLDFD TNRDGWISPK
     EFQRAMESQK MYTVEDITYL MMCTDVNNDG KVDYMEFTER FHNPARDIGF NLAVLLTNLK
     EHITNDPRLE KIIEKAQTLL EYFDPFLGRI EIMGSSKRVE KIYFEIQESW LEQWGKQQIR
     DSKNSFLFNV LQDDGGDQGK LEAFINFCED TIFEMQHAAE ISSGDSDSKM ERALKQRDYF
     LQQSSAGE
//
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