ID A0A158PPR5_ANISI Unreviewed; 1903 AA.
AC A0A158PPR5;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 08-NOV-2023, entry version 27.
DE SubName: Full=Receptor-mediated endocytosis protein 6 (inferred by orthology to a C. elegans protein) {ECO:0000313|WBParaSite:ASIM_0001531801-mRNA-1};
GN ORFNames=ASIM_LOCUS14728 {ECO:0000313|EMBL:VDK53186.1};
OS Anisakis simplex (Herring worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Ascaridomorpha; Ascaridoidea; Anisakidae; Anisakis;
OC Anisakis simplex complex.
OX NCBI_TaxID=6269 {ECO:0000313|Proteomes:UP000036680, ECO:0000313|WBParaSite:ASIM_0001531801-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:ASIM_0001531801-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDK53186.1, ECO:0000313|Proteomes:UP000267096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the GAPVD1 family.
CC {ECO:0000256|ARBA:ARBA00008489}.
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DR EMBL; UYRR01031898; VDK53186.1; -; Genomic_DNA.
DR WBParaSite; ASIM_0001531801-mRNA-1; ASIM_0001531801-mRNA-1; ASIM_0001531801.
DR Proteomes; UP000036680; Unplaced.
DR Proteomes; UP000267096; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR InterPro; IPR041545; DUF5601.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR045046; Vps9-like.
DR InterPro; IPR037191; VPS9_dom_sf.
DR PANTHER; PTHR23101:SF25; GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR23101; RAB GDP/GTP EXCHANGE FACTOR; 1.
DR Pfam; PF18151; DUF5601; 1.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF02204; VPS9; 1.
DR SMART; SM00167; VPS9; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS51205; VPS9; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000267096}.
FT DOMAIN 155..301
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 1533..1687
FT /note="VPS9"
FT /evidence="ECO:0000259|PROSITE:PS51205"
FT REGION 389..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 510..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 890..915
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 930..968
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1062..1115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 19..53
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 395..438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 510..529
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 572..630
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 890..913
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 951..968
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1072..1090
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1091..1109
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1903 AA; 212517 MW; 5FB9C45237674DF7 CRC64;
MDMCNWQLNN SLSILCERLR SEKLLVASEL ENIQRLNEQI DEEQLLLAQL SWIVNRQQDI
LNRLVNSHPS VLPENSCLLN AQLDSADFIE AYQRIDAHHY SSLTSILNTL YKSPKSVAEL
LNASDQIVKE SEESNEGFVS CIFSFLYGCC VFPNDERYLL EVLSYLIDMQ LSSNSDPRRV
LRKGNAAFCR LYRLFSEGLF IDIFLTAALH DPVMYVLSQD DIFLDIDPSK SAIRFPPEER
RRRFGEDENS LSYLQRLSAH RKVIESKLIA ISTRFVQGIT EAMSCFPQSL SWLVKELYST
LIDRNKLTTE QGSMAQIVHR VLESSGESLN ELFSKNTFDS HQCEQHLRRS FVANFSELNC
FHAILRSSAI ERITDTNIRR DIRNLIRRMP SRFDAPNSPQ RNIDTKNESR MSPPISNKSD
GNAQNSTLSP TSSRSNKLRT FADRVQTVAH KGQLRLRSQH SSQQDSNGSH PGAASNVEVL
IFALGDNSEP LGLCSEEKFM ESLRQPLSIR KHKTSDGASE KRTRFLDSES IGMSDRVTDA
GSEDEEEGAS LSSSIEGNAE DALEDDAEDV SSTLPDNFSD VGLISANVSG RGSPSISGPP
SVSGRDTPQS SHTDAAVQQD TSNANANNTT RTRHHLHRSN MPNLPLSVRR ENSEGLEDKF
GKFGLPQQDN KHRYRDDTHS LVSDSWSTDV QPSDTEGIMT DTRHEAISNL PANIQQLLQP
PNNDTNNTHQ IPIVSEETAP SRPLSAVTNR MTNRLPTSTT ANNNAATANI ASNTTANQAG
AASSSSLGIL MNSEDRSDTW SVDAMASDSE ADNMLVHNRN DDLLLINDDD STDQRIDTAS
GTSGGDTPLL MSTQSETSLA SGVISAATQS KHLNPSKNVT TDSLNEQIHR GNIDSSTNDP
ISNNSNRSHQ QQAKKKVPPV DVSVFDEIPS NSALPPNVPS IGEVAANGNS RERLRRQSSG
SSFYSKSDID SEFSKDLNED ALSTLLAEYV PMSSSYNPTS NIMDLITTNA NSHTTSTSPA
ASILARAGSF CNDDIDNQSI SQQRDHSLSP INNTFPFNVT KQRKDVSEMD RVGELSQSNA
CCPHSSDVHN DTKLANSDEK SEDGDKSTSK NVDVNTNAIS GGIQTAATAN TSGFARKKIN
IFQGLQKVGE SLKMRKGMAV SSLKQSLSQA TTMNELASVD ANSNPSMCVS NDKPNTFKRD
TQQDITGRKR LTGSHSMGEL GCLREKNESN EHTANAILDK YKGKHAIVID YNNSPDNLER
VSNQLHPAQQ CISVLSSSSS LSYLPYYDAN NVTQCRAFID AKRKLRLVLS SIGSSSLPDL
SNMTISEHST VDYSLSSANQ INKRGECNDA QYLKNFLQIL LAESINGQEK TLSAQIREVL
RCITVFSDKE IRKLLRTLKD EHRKRTAYVL YLQQSRLTLL QYRSYLEKLL NRVQREKSLT
VECLVEVLVR FYLQQRDMYV RRFINDFQLL KAQDERTDAV ERALTMLYER MPNEAMWKDA
DKEMLAYARK SVERSIMAQI HLIAFYPNGE ADQCRDSVFH KSLRKLAQII TPDHAELRIP
QRFHGECPWP SAQAEISIIN AYKSPRDKIA CVVRCCETIQ NLIFLAPQRG TASADDITPL
LVYILIQANP QALLSNIQYI NGFYGNRLEG AEAYWEFGVE NLEESSYVSC MNSALERNYQ
CFADGTVNTS ILMSEMESDE SGSRNVLLGT IDEHLVRMRD HIKVVLGKQR SKVYFSYFKE
WLRGHKSQEE FNGLGLAMMP TDQKFVHSDF FVTMKKLCDM QHKEDNAVRI FDDNRLTKQQ
KDLNASAQGV SNDQAIKKPR LISDIEYVDT RQSTAIVPSI PTEYNAMMEG LSEVHPFSGW
LPSKGQIKGR MLLAVWEHGI ESITDDCINP LLVVIRVSFI LSF
//
