ID A0A158PRE7_BRUPA Unreviewed; 1160 AA.
AC A0A158PRE7;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 {ECO:0000313|WBParaSite:BPAG_0001008801-mRNA-1};
GN ORFNames=BPAG_LOCUS10050 {ECO:0000313|EMBL:VDN91236.1};
OS Brugia pahangi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0001008801-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:BPAG_0001008801-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN91236.1, ECO:0000313|Proteomes:UP000278627}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; UZAD01013173; VDN91236.1; -; Genomic_DNA.
DR STRING; 6280.A0A158PRE7; -.
DR WBParaSite; BPAG_0001008801-mRNA-1; BPAG_0001008801-mRNA-1; BPAG_0001008801.
DR Proteomes; UP000038020; Unplaced.
DR Proteomes; UP000278627; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd08834; ArfGap_ASAP; 1.
DR CDD; cd07604; BAR_ASAPs; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR043593; ASAP.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45854:SF3; ARFGAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45854; ASAP FAMILY MEMBER; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Reference proteome {ECO:0000313|Proteomes:UP000278627};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 340..433
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 463..585
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 1095..1160
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 795..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 899..923
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 908..923
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1160 AA; 130459 MW; 7E59FD1C08D0A73D CRC64;
MTASEGEGSY GAMLSSFTTS VKADLDSPVT SNFGNRIAEY RVEAQRIVEE TEGYTVDFER
LRKVSKEVED TLVILVRQLL AFGQAAKEIA TKWTSRSESQ YESDVAVILM KMECHIKDEA
DLTNLQMRNW QSNIVTPFLT LVEIGREIRN RGVERSCRDY ENKYVKAEAD ARKHAKHAGY
TRSQLGHGEL AEQLTRERLM VQYELCKFLM SVDTVEDRRG PQLLRHFMEL VRNQNSYYMN
RVRVNEDFRQ DMTKLEERMM TRNANRCAQR NTLWDLKGQL EANDELARCA SGRRSSGRDS
VNLGSRLSGI NLVNASNALL NDNDPLNELA TSTAFFPDLD FTQSGYLYKK SNKKLHKQWQ
KRRCRIEDGH FWLSHSDESA PPTKLSLLVS DCKPSTDDPK SFDLYCRERT YHLQADSETD
AKRWMLALKR EITRVKAKML SAETPQGNEG GSSGAISELY ERKMCVAKVR KLPGNNVCAD
CSSKEDVQWL SNIGALVCIA CSGVHRELGV HVSRIQSLNL DVISPLEFLV PLSSGNIMIN
RLFEYDAAKC ATWKPIPGCT RFDRQRFIQM KYRDRTFVQE LDDPDASLTE AFNNCDFENT
YRALLSPNLS KKPFFRNGPF HQMVLRETSL SLPLADLVMQ LRIEISDMEA IIMDCIRCGN
ADMVAVLLRY RSLSSAVRSI HLHSLITCSE NAQQKKITET LRSLQLGDST QVQNVAVPPI
LFISTPDSAS LSRSSSSVSS CPHLPSDSTA SQNVISKPVN VLMRNGTTIS VPQSPLSMED
TGGNRLSKQI FVESEPAHSL VERETSAHNS TQTSGSKNFD ERKEFLPFVV PLCTSTPSSN
VDSARVATHS NHYSVTLPSI PISSSPPISV TPAQNMAKSY IRSASEYSRT ANCFEDPGDR
SATVRSLPGH LAPQSSSTRD NDEIMGTTFP IVASISLDPI PLNAQKQEMN IYVVAPGKEE
IIDKQKCVAE AQNERERPAR NPYITNEQGY FSYDIISSRG IRMDDIISNF VKGTSSAFDQ
ARSNFTSDNE HARFSVMNSL AANNLRREMP RYMSRSIRLT RPAPAPPPLI GVKLKPPIPA
PRRFPSLSRE NKQRDCARRC RALYDCKADN ADELSFRQGD IIVITKEKIT GESDIWMEGY
LENNPLCKGV FPTTFVTFLS
//
