ID A0A158PRW1_BRUPA Unreviewed; 1281 AA.
AC A0A158PRW1;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
GN ORFNames=BPAG_LOCUS11342 {ECO:0000313|EMBL:VDN92528.1};
OS Brugia pahangi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6280 {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0001138001-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:BPAG_0001138001-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN92528.1, ECO:0000313|Proteomes:UP000278627}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
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DR EMBL; UZAD01013225; VDN92528.1; -; Genomic_DNA.
DR STRING; 6280.A0A158PRW1; -.
DR WBParaSite; BPAG_0001138001-mRNA-1; BPAG_0001138001-mRNA-1; BPAG_0001138001.
DR Proteomes; UP000038020; Unplaced.
DR Proteomes; UP000278627; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR CDD; cd00096; Ig; 2.
DR CDD; cd00192; PTKc; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24416:SF503; PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PIRSF; PIRSF000615; TyrPK_CSF1-R; 3.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 4.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50835; IG_LIKE; 4.
DR PROSITE; PS00290; IG_MHC; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Magnesium {ECO:0000256|PIRSR:PIRSR000615-3};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000615-3};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000278627};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 60..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 813..836
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 84..185
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 291..383
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 612..714
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 723..809
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 895..1220
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT ACT_SITE 1083
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-1"
FT BINDING 934
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
FT BINDING 1088
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-3"
FT BINDING 1101
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-3"
SQ SEQUENCE 1281 AA; 147730 MW; 590157958A28E29C CRC64;
MAVQCSNPWP FRFGSSRHEV YSRSLYTAPT TFSTKEHYHI SFDYSLPTPH CRTSCWRFML
LFYPFIRYLL IAVCFITIDA SLYPPVIIGN KDFQEYKGQP YTEKKDGETL ELNCSTTEAV
KWILPDNIFH TNFDPKERTG RVIESSFDIG FRSLRIEQLK SSDTGEYVCV AEHSGFSSSV
YVYVSSNKNG KSVRTGSFLN SGPLIISKEL RGLNVILPCR TDKFIESGVE LFINHIKQTG
EIQFDPRIGF IVDRGLLNDR AEVPVRCEYL GHTSEMIIVP IKNDKEMEYS PVIEVSNTWP
YVSQELNMNC TFHTRDGFRY MLTWKCPQCE NETDRVVSNR YMKIGDGIKK LLFIRDLRES
DSGNYECIVT NRDDGHDVRR STHRLQVSPT RGQLKVIDFS ENIDSEEGKT VRLFHIARAF
PSDEYSSEWR KYSKTISSGE EFMEIIKKDI RSEMNADLHE DELSIINATV DDSAIYQLVI
RVSQDYIYRK NWTLSIRPID IQPHITIHDQ FGQLLLSDVL IDSKIIVTCL VKDTRSHKLR
LLYVTRGGEW EQPDDSKELS GFTFESAIKW ITYAKEHMRI RCEDDEANKV DEKNLVVSEV
ETINASFIAK KPIDLLNEDN SIYEKDHLEL ICILPLNDDL LVPNLLACLE NMMYFSDVVW
MRDDVQLAYP ERHVTIYSQK FITTLDDISS NESGDYECIA KSKNTHIYRS YTLHIKINVV
VAPHIVGTEE EYEHLAKYGE KAELVCPIEG EPEPLYRWLK NGIEYNGYGS LTKKIDFPRV
LVEDKATYTC VAKNRAGSQQ LVDEPAYIRS SKYWWTLGFA TVSVLVLLLM ALLFLLKQRC
KSKRQEERLR ALYNQLMSES NGEYHDGSIG LKQPLHERVE QLPYDRRYEI NKDKLFFKQS
LGGGHFGQVY LGELSKPRVS DSLAVSDVLK VAIKAPRDGR NVHHQKALAD ELKIMIAVGV
HPNVLCLIGA VTKQMSSGQL YMIMEYCEND NLKDYLSKNS AGFLNEVEIS REPLSSDGYL
TPTRNAQHKA QIYLAELKLQ WAIEVDEERM AGKMITTSDL ISFGYQVANG MEYLSSKTCI
HRDIAARNIL VTKKRAIRIA DFGLARKDST VYHIRSSQSV PLPLKWMALE SILYHNFTEQ
SDVWSYGVLL WEIFSLGKVP YPQIDNNDLL SYLLEENRME QPKLAPDDIY NLMRQCWLSD
PSNRPMFSEC KVLMKTHLSR ASPPLSTRLD KILEEDQIMM EKYSEWRDSE EIEQDLRSQA
TRNGFIAIPT QEPQTNSNIY M
//
