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Database: UniProt
Entry: A0A158PS71_BRUPA
LinkDB: A0A158PS71_BRUPA
Original site: A0A158PS71_BRUPA 
ID   A0A158PS71_BRUPA        Unreviewed;       847 AA.
AC   A0A158PS71;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   05-OCT-2016, entry version 4.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Brugia pahangi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Spirurida;
OC   Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6280 {ECO:0000313|WBParaSite:BPAG_0001231401-mRNA-1};
RN   [1] {ECO:0000313|Proteomes:UP000038020, ECO:0000313|WBParaSite:BPAG_0001231401-mRNA-1}
RP   NUCLEOTIDE SEQUENCE.
RG   Helminth Genomes Consortium;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:BPAG_0001231401-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   WBParaSite; BPAG_0001231401-mRNA-1; BPAG_0001231401-mRNA-1; BPAG_0001231401.
DR   Proteomes; UP000038020; Genome Assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 2.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000038020};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000038020};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    424    448       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    468    485       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    585    604       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    616    637       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    672    691       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    723    744       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    779    805       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    125       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   847 AA;  97871 MW;  82C61C2418815F44 CRC64;
     MGSLYRSELM SLCQLFLHSE MAYDEIAKLG ELGVVHFIDL NSEMSSFQRR FVGDLKRCDL
     MAQKLKFIEE QILADSIPIP RLNEFVPAPR PSEMNTLETE IGEIEEQLLE NNKNMKNLMD
     NYAQLNECMQ CINKVQQLLT DGQRQQARQS LLGMENPTSG IGAIRRKLTN VMIGRKDSII
     PDRMSSIFSG ENFVAGIVER CHSTALERLL WRTCGLNVFV RTVTIDFSED PLLNDIPPKD
     VFMVFFSGAV LGLRVRKICK CYQAKIYDYK DPANNRVLHV PSLFGRVAEI KSIIEETRKY
     RNTLLRAAAF KAHEWDTKLQ KMSAIFVVMN MCNVDITQRY LIAECWIPTA DIIRVRKNFE
     KTGMLAQEKN GYVFLCQIET NKVPPTYFRV NKFTKIFQSI VNSYSIATYR EINPAPWTMI
     TFPFLFAVMF GDAGHGLIMF FVALAFILFE NKIKIDDEIM GSFYRGRYII LLMGLFSIYT
     GFIYNDFYSR SMNLFGSSWH NPYKSNLLEL TPVDMQFDLI LPPQYAYDRD KGPYVFGLDP
     VWNLAENRLT FTNSMKMKAS IVFGIIQMTY FRSTIDIYFT FIPQILFLSC VLIYLCIQIT
     VKWLMFSSIP GNVFGFFYPG SHCAPSLLIG LINMCMLKPR KEGFWNRSSS SEFEQCYLHE
     WYPNQGMVEK GLLMLTVLCI PVMLLVKPIY LKFKPQKIGH DEVANTDTYA VKFDFMDVMM
     YQGIHTIEFV LGCISHTASY LRLWALSLAH AQLSEVLWSM VLSMAFSLNT WLGGPVLYLV
     FWLYGMLTFA ILILMEGLST FLHVLRLHWV EFQSKFYDGH GYSFKPFAFT QMKSFEIANK
     KDKNVIC
//
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