ID A0A158PSX9_9BILA Unreviewed; 1358 AA.
AC A0A158PSX9;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Phosphoinositide phospholipase C {ECO:0000256|ARBA:ARBA00012368, ECO:0000256|RuleBase:RU361133};
DE EC=3.1.4.11 {ECO:0000256|ARBA:ARBA00012368, ECO:0000256|RuleBase:RU361133};
GN ORFNames=BTMF_LOCUS6079 {ECO:0000313|EMBL:VDO20803.1};
OS Brugia timori.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=42155 {ECO:0000313|Proteomes:UP000050602, ECO:0000313|WBParaSite:BTMF_0000798001-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:BTMF_0000798001-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDO20803.1, ECO:0000313|Proteomes:UP000280834}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-
CC bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-
CC diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456,
CC ChEBI:CHEBI:203600; EC=3.1.4.11;
CC Evidence={ECO:0000256|RuleBase:RU361133};
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DR EMBL; UZAG01015489; VDO20803.1; -; Genomic_DNA.
DR STRING; 42155.A0A158PSX9; -.
DR WBParaSite; BTMF_0000798001-mRNA-1; BTMF_0000798001-mRNA-1; BTMF_0000798001.
DR Proteomes; UP000050602; Unplaced.
DR Proteomes; UP000280834; Unassembled WGS sequence.
DR GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:UniProtKB-EC.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR CDD; cd00275; C2_PLC_like; 1.
DR CDD; cd10341; SH2_N-SH2_PLC_gamma_like; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 3.20.20.190; Phosphatidylinositol (PI) phosphodiesterase; 2.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001192; PI-PLC_fam.
DR InterPro; IPR035024; PLC-gamma_N-SH2.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR InterPro; IPR000909; PLipase_C_PInositol-sp_X_dom.
DR InterPro; IPR001711; PLipase_C_Pinositol-sp_Y.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10336:SF36; 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA PLC-3; 1.
DR PANTHER; PTHR10336; PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00388; PI-PLC-X; 1.
DR Pfam; PF00387; PI-PLC-Y; 1.
DR Pfam; PF00017; SH2; 2.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00390; PHPHLIPASEC.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00239; C2; 1.
DR SMART; SM00148; PLCXc; 1.
DR SMART; SM00149; PLCYc; 1.
DR SMART; SM00252; SH2; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50007; PIPLC_X_DOMAIN; 1.
DR PROSITE; PS50008; PIPLC_Y_DOMAIN; 1.
DR PROSITE; PS50001; SH2; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Hydrolase {ECO:0000256|RuleBase:RU361133};
KW Lipid degradation {ECO:0000256|RuleBase:RU361133};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098,
KW ECO:0000256|RuleBase:RU361133};
KW Reference proteome {ECO:0000313|Proteomes:UP000280834};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transducer {ECO:0000256|ARBA:ARBA00023224}.
FT DOMAIN 610..709
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 720..809
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 838..896
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 931..967
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 989..1111
FT /note="PI-PLC Y-box"
FT /evidence="ECO:0000259|PROSITE:PS50008"
FT DOMAIN 1114..1247
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
SQ SEQUENCE 1358 AA; 157093 MW; 59EA28AECCFF6AD9 CRC64;
MYPQSSADSV LLFQRPFVFT SNSLMTSSSV EFEMEKVFHA MEMGHNVYKL LLMKRRDPAQ
KRLTYNRETR QLFLSKLDNY DKSGGKTLRL DLRIVKEVHT LDFKLKKIKI GDKWEKDKEI
KQFDATRILV LSYATTFNLR YWILLFDTED LCRMWCQGVH YLMLDTISAC HALLVERWLR
KEFYNIAGYA LENPCVAMKH MKPFVQTSLQ YKVQSKQLQE VCEETMHYDS FANAYRKLLH
ANSLFAEHFA AYSDDAAVVS FNNFLRFHKD KQNDEIGMMR EKASDFLRHF LRQWDPYRDV
REPALSVTEF CDFLFSRENS LWDSVNENVI HDMNRPLSHY WIASSHNTLI LYLTGDQLKS
ESSLDTYARA LLMGCRCVER MLLFVLIDTI DCWDGQKRNS GEIQDIVIYH GYTMTSKINL
RDVLYTIRHY AFINSEFPVI LSIEDNCSVP VQRLLAREIR EILGDYLLTA PVSREETCLP
SPEALKRKII LKHKKLPTES ENIILQQADE DQEQDLLLLN FTRQGILSLK SGISDEWTTH
LFILFPDRLC YMLEQCENNI DNQGILRRQD SLGNAHDDEN QVMCLVYIDV LTNLTGFGVP
PEEMHITEEW FHGKTDRDTA RIRLLEHKDK GNGLFLVRDS TIFIGDYSLS FLHNEKVHHC
RIRTRMVNGE KKYYFLENKQ MDTLYELISH YTKERLRTPN FSTTLITPCP QPCPHLGMIW
FCEKTDRNRA EELLNTVQQD GAFLLRFSST DKNVFVLSLR VDGEIWHYHL KRDGRIFVVN
QTIFENLNQI VEYYSTREFV RGICLKYPVG EDTIIGSAGI CCSTDRALGC YMELKDIDKE
VLVRAIESYN GSLPCELSFP VNAVINVFRK DGDRWRGKYR GRSGFFPSRC VIELETSDNQ
PSELGPYAAI DLADSLIEEV PFEIAGRPFA FKIRRVSTHW NPSEYVLAAN SSEEREDWLN
ILHELMRTVT DRNTLIRTRE KNLRIASELS DLVVYCQAVP FNSQFATLLE KANSENIVAQ
GNFYEMCSFS ETKFEKLVER GLVQFNARQL SRVYPQGSRV TSANYDPVPM WNAACHMVAL
NYQTGDRSMQ LNQGKFMANG QCGYVLKPSY MIDEMFSPDA AEVVSTSCPI ILTVHVNIYS
LFNWKGGQHL SRKDRNRGIC SPTVTVEVVG LPADSTSVRT RAIASNGLNP VWNEKFIFKV
YCPEIALLRL YVEDGDFMGP KMDPFIGQAV YPLDCIRTGF RSVPLRNQYS EELELSSLLV
YLDMRRRSNE AEVLNPHVDL QSDRYVAGGL HKTLTSSGVF SARLNSTDQS SFTVPLTPNL
SVAKQVQVLM DSTSVEYFFF XXXXXXXXXX XXXWIRRP
//
