ID A0A158Q2K0_DRAME Unreviewed; 831 AA.
AC A0A158Q2K0;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
OS Dracunculus medinensis (Guinea worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000029801-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:DME_0000029801-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR AlphaFoldDB; A0A158Q2K0; -.
DR WBParaSite; DME_0000029801-mRNA-1; DME_0000029801-mRNA-1; DME_0000029801.
DR Proteomes; UP000038040; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd20809; C1_MRCK; 1.
DR CDD; cd00132; CRIB; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR000095; CRIB_dom.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR22988; MYOTONIC DYSTROPHY S/T KINASE-RELATED; 1.
DR PANTHER; PTHR22988:SF66; SERINE_THREONINE-PROTEIN KINASE GENGHIS KHAN; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00780; CNH; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00285; PBD; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50108; CRIB; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 69..119
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 307..592
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT DOMAIN 669..682
FT /note="CRIB"
FT /evidence="ECO:0000259|PROSITE:PS50108"
FT REGION 645..669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..662
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 831 AA; 91957 MW; FF59205D4B7EEA7D CRC64;
LNIIDLNAKI FLYFLNFSAS TSHSSATYEN AHVGTPTPST ASTLVLGTQG RGASPKVIQS
LNNALNGKGH RFSHVHLQTP SKCAHCTSIL IGLDRQGLFC QDCQYACHVH CAPKVPTSCP
VPPEARRPLG IDPQKGVGTA YEGLVKTPKP AGVKRGWQST YVVVCDFKLY LYDCNIDKHG
KAIDIHPMIR QVFFVLDMRD PDFNVSSVIE SDVIHASKSD LPKIFRVTTS QIHSMLPTVT
VNTTGSNSSN GSAGSDTPIA RHLTFQEKTK WVIALNELKN LLRKSKLVDK SAFLVKEVFD
SLTFRELRNA QCATVLDKSK IVMGFADYGL YAIDLDREIL VPIGGERENN KRTVEQIEYN
ADEQLFVAMV GVVKERHIRL IPTAALDGRD LKWIKVADTK GCHLLTLGAG SSNDPHNYFC
VAVKKTVLVY QIDRSEKRHR KVRDLAMPGH PQTISIMRGK LCVGYPSGFR MWDLADNSTT
ALVNLEDASL QFLNQTLYDA HLIINVSGYE QKEFLLIFSR LGVYVDAQGR RCRSQELMFP
SEASSGGFSC IMPHLCVYSE NEIDVFNVNS AEWVQTINLR KASPLTSDGR LTVCVINDLP
YVVLLSDVLS DEDVLSLPDW TQPSIANIPS SSSLIKGITA KRRRKFSMKT PREDDRYGRS
GDRRSQLPIS GPSDFVHIVH MGPGAGLELQ NLIDLKNSNP SHVTSSSSLG SGAADKVRQL
INPIMRSTSS TTTNLHGVHQ LTNTSRREIE LMQSKSRPLS SHSKGSDGIG VLPKASITST
NSHFLELKAV QKDAVKTNQL HWDTTTEPCL PSRSRSSLQI KQKRHNSQHD F
//
