ID A0A158Q2Z1_DRAME Unreviewed; 898 AA.
AC A0A158Q2Z1;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=PH domain-containing protein {ECO:0000313|WBParaSite:DME_0000118301-mRNA-1};
GN ORFNames=DME_LOCUS5543 {ECO:0000313|EMBL:VDN55570.1};
OS Dracunculus medinensis (Guinea worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000118301-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:DME_0000118301-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN55570.1, ECO:0000313|Proteomes:UP000274756}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the MELT/VEPH family.
CC {ECO:0000256|ARBA:ARBA00010187}.
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DR EMBL; UYYG01001152; VDN55570.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A158Q2Z1; -.
DR WBParaSite; DME_0000118301-mRNA-1; DME_0000118301-mRNA-1; DME_0000118301.
DR Proteomes; UP000038040; Unplaced.
DR Proteomes; UP000274756; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039888; Melted-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR21630:SF10; VENTRICULAR ZONE-EXPRESSED PH DOMAIN-CONTAINING PROTEIN HOMOLOG 1; 1.
DR PANTHER; PTHR21630; VEPH-A/MELTED; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000274756}.
FT DOMAIN 779..887
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 898 AA; 100235 MW; 3BA0B6F10F15D3E1 CRC64;
MQSTLAKIIV IFNNPTYCRN STDQSVVEIV LARIAAAIRE TKSIEVYAPV LVDTLAMCLS
HKMTQIGVNG PQDTPHCKIA CDILSSLFLH YGNKSVMTVT VPTAIRALSC GSDELTRSTT
SYLQLAAIHH GRLLAQYSIQ IISNIINGNF PLARVVPQIY PENREPFHAH FPQLLRLLQN
EETDQSERLS VLQFASMVTN ANPDLILGYL EDLDSFLQLS STRTAILHIF LSLISLNRTF
ALVPRLCALR NAAIGTECDN TLAMIAKIVG VIGRVDCETA NIAANDLIGM CKRRSESMPT
ILKEIEGVAE CYPLAVLPHL NFILTLPTAK PSTAAVCARI QVLCSDDARR RNGLLSSPND
DITVIKVING VDQSEESIIS SKISVKTDGP IISSGIRTTV NIGDSGVGDH SAQELDKNTE
TLANAYMNNR NRSNCSLTNH KSRSYASLNP YCENISVVDT NSRDSPLSVI SSHAGRRTDG
SGFMPTYPPP SYHPPKGDAS SKSKVHLIPT AIHIGKDGRV RPLAMHTRRN TPQWIPTSSN
SASYETTFPA NSGPVTTKLA SGSGSTVHVI EEQNDSIPEI QSTGEDSQQN NETCDRGDVV
RQFVDHRRSK IRNYVTNLTR NYPIPIQCTV EGTKGTKLRM RVHFRCQIRD SHCIFDANNM
FAFKTRVAPI WLHLMFLQME ASSLESTGEV VAQSSEAFRT LSHCWSCLPT NYTKNRPFIT
LATSAFPALK EQEQIYKELQ EARYFDSFTF SMHYQKWSCF SCNYPERVRS ILRSDSPNIP
VIEGQLKEKR GRWKFLKRWH TKYFTLSSAA LTYRDRPQDP STDKILCPSI DLRKIRSIKS
LSKGRKSRKS LPKAFEIFTD DDVSYVLKAN DRSKAEEWFQ CLQIAVAQAH KERQSIAF
//
