ID   A0A158Q431_DRAME        Unreviewed;       421 AA.
AC   A0A158Q431;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial {ECO:0000256|ARBA:ARBA00017279, ECO:0000256|PIRNR:PIRNR000543};
GN   ORFNames=DME_LOCUS7891 {ECO:0000313|EMBL:VDN57918.1};
OS   Dracunculus medinensis (Guinea worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX   NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000388601-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:DME_0000388601-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (APR-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDN57918.1, ECO:0000313|Proteomes:UP000274756}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I), that is believed not to be
CC       involved in catalysis. Complex I functions in the transfer of electrons
CC       from NADH to the respiratory chain. The immediate electron acceptor for
CC       the enzyme is believed to be ubiquinone.
CC       {ECO:0000256|ARBA:ARBA00003195, ECO:0000256|PIRNR:PIRNR000543}.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974,
CC         ECO:0000256|PIRNR:PIRNR000543};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC       {ECO:0000256|ARBA:ARBA00004305, ECO:0000256|PIRNR:PIRNR000543}.
CC   -!- SIMILARITY: Belongs to the complex I NDUFA10 subunit family.
CC       {ECO:0000256|ARBA:ARBA00008606, ECO:0000256|PIRNR:PIRNR000543}.
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DR   EMBL; UYYG01001164; VDN57918.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A158Q431; -.
DR   STRING; 318479.A0A158Q431; -.
DR   WBParaSite; DME_0000388601-mRNA-1; DME_0000388601-mRNA-1; DME_0000388601.
DR   Proteomes; UP000038040; Unplaced.
DR   Proteomes; UP000274756; Unassembled WGS sequence.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:InterPro.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR031314; DNK_dom.
DR   InterPro; IPR015828; NDUFA10.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10513; DEOXYNUCLEOSIDE KINASE; 1.
DR   PANTHER; PTHR10513:SF15; NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 10, MITOCHONDRIAL; 1.
DR   Pfam; PF01712; dNK; 1.
DR   PIRSF; PIRSF000543; NADH_UQ_42KD; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Electron transport {ECO:0000256|ARBA:ARBA00022982,
KW   ECO:0000256|PIRNR:PIRNR000543};
KW   FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|PIRNR:PIRNR000543};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW   ECO:0000256|PIRNR:PIRNR000543};
KW   Mitochondrion {ECO:0000256|PIRNR:PIRNR000543};
KW   Reference proteome {ECO:0000313|Proteomes:UP000274756};
KW   Respiratory chain {ECO:0000256|ARBA:ARBA00022660,
KW   ECO:0000256|PIRNR:PIRNR000543};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR000543}.
FT   DOMAIN          86..324
FT                   /note="Deoxynucleoside kinase"
FT                   /evidence="ECO:0000259|Pfam:PF01712"
SQ   SEQUENCE   421 AA;  49177 MW;  52FFC342621BFE1E CRC64;
     MSINGLKIFR NVVVHRFSPL LPKKIFLSSL NSLALMQKRS IVHKNSLKLD EETYPEPWPY
     KEKGFSFFHA IFDRTQPRFH QNSKLIVVEG NIGSGKTHTA KEIADQLGFY FMPEFKMEHI
     LIDRYGNDLR NFYHLIPQSY RVPDMEMFYK NPGSNMTAVM CNKIFQCRFE QYLNALAHIL
     NTGQGVVLER SPFSDFIFIN ALRSKNYIGP EYFKHYYYVR KNALAKLFFW PHLVIYLDAP
     IETCLQNIRN EGNIDKAAVA DASFISIIAD SYKDCIKEFR PHSKILVYDW TMPGDTDRII
     EDIENIDFDF FEWHSGDVFE EWFTTIGEIA WGGWRIYVTS KFEAYMRAFG GIPTHEVNEL
     YVNPRDTGHF LNVIQKEVLK SPYTYGYNPK YGDSIFAGFI VGGGKVLLPE PWLVSIFFKF
     R
//