ID A0A158Q4G9_DRAME Unreviewed; 1280 AA.
AC A0A158Q4G9;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Nephrin {ECO:0000313|WBParaSite:DME_0000481901-mRNA-1};
GN ORFNames=DME_LOCUS8702 {ECO:0000313|EMBL:VDN58729.1};
OS Dracunculus medinensis (Guinea worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Dracunculoidea; Dracunculidae; Dracunculus.
OX NCBI_TaxID=318479 {ECO:0000313|Proteomes:UP000038040, ECO:0000313|WBParaSite:DME_0000481901-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:DME_0000481901-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN58729.1, ECO:0000313|Proteomes:UP000274756}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; UYYG01001171; VDN58729.1; -; Genomic_DNA.
DR STRING; 318479.A0A158Q4G9; -.
DR WBParaSite; DME_0000481901-mRNA-1; DME_0000481901-mRNA-1; DME_0000481901.
DR Proteomes; UP000038040; Unplaced.
DR Proteomes; UP000274756; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR11640:SF164; MAM DOMAIN-CONTAINING GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR PROTEIN 1; 1.
DR PANTHER; PTHR11640; NEPHRIN; 1.
DR Pfam; PF08205; C2-set_2; 3.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00409; IG; 8.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 9.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50835; IG_LIKE; 8.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000274756};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1280
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041044454"
FT TRANSMEM 1045..1067
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..139
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 144..242
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 252..342
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 347..442
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 446..538
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 543..641
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 741..824
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 832..931
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 938..1028
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1104..1131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1117..1131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1280 AA; 142471 MW; 2B3A5F1424CF33F7 CRC64;
MRFVKILFLL LLINNIFGFN EININNNNDS GKDNDAQFAE KPKNQTVLLG ENVLLKCVAK
PSYSGEALYS QWKSNDGALL GFNDAGVLAG HGQRYSYIRE NINEKHLLIT NVTLDDDGQF
ECQMTRIRTG GFRASAYVNV IVPPTEVKLL GHNSGEVIAV EENIILNISC GAFNAKPAAI
IHWHVNGRKI HDEVYRWNTQ NINKTVTTFA AVLWKPSRND NKKIFTCESS HSSSIIQRVN
FTLNVLYPAD KPRITLLNDN DILRVGNNIT LLCSTVGGNP PPNVTWLLDQ RIISNAFQYN
ADNLETTNAY SMVVGAEDNG VNFICQSWNH KDNAVRERIQ LDVAFAPLGV DIYAESSVRL
GRTMYVHCRS RLSNPASKII WLINGIVASS ANETVYQQSN GFISLSNITF NTADVSSSNF
RIIVECIAKN NEGTAKKQHT IRILSPPGEP VIYGTDETLL EGEVLNMTCE SHGGNPLAAL
SWYRSVEKVQ ETKSAVSGDI SQSMISILLD RTMNKQHIKC EANNGALDEP LSATRTIRVL
FPPRHLIIRK ESQTGHKVIS GELAKFICIV PSSNPAANID WKFENDFTNF REENRRNKSS
HEFGGFEVES LVEFIPTEDL DGYNLKCIAS HPLWNTQKTS SFPLVVLYAP NAVVDGPITI
AVTEGDSFKE NITIRANPPV STWRWKKNGV PFEYTVGAII ARGSTISGRS VGRSDSGLYS
LMAINSIGMA NISVRLTVEF PAYVKHITPI TIASDGEEVD MECVVNGFPK KNGMVKWLYN
GAPIISMFVE ETRAVLRINA SHETSGAYIC VADNGIGKPN QTTTYLLIKK APSIDRQSSF
LRAAGPIGGH ARLRCRVVAV PDVTFHWTVD GRISPLRYND SKYSFYSVAI NHSTFESTLL
ISGLDQYDYQ RKVKCLAMNR LGDDSIEIQV GPLTTPDVPI TIRAVNVSKS SIVLNWMAGF
DGGADQIFEI RYRIYSENVY HTLNSTSSNI EIKGLKPASR YEIAIRAINA RGFSSSYSRP
IYAYTKDKNG VDLSVVDQSD SFSPFMVALF GFGGLVLLII NCMLLCYMHR RQKKKKIQEK
TEMVRKSQGD SDVRPVQMYG ALTNMDNSYR PDSTNTNRSE LAREHASEDD QSVRTMIEVN
PEGYVQQVDP SMFYDRGSHM ECDFDPNFYA SVIRSETLRN TAPTSYTNIH YTDSSTPQIS
ITSHGYDDKS SIYKSTLPRA HGINSPPGIR VPRIIDTNPS LNNISNNNNN ITPQMLRTFV
HPNGIHTAPL DYSHIDGDLV
//
